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A biotool is a molecule that has been discovered, characterized, sometimes further developped, up to the level of a (or several) publication(s) or a patent(s), and with valuable informations on several key indicators such as target identity, high affinity/selectivity, functional effects in vitro, functional effects in vivo, compound availibility, physicochemical data, Pharmacokinetic data etc...


Biotools name Target nature
3'dATP (or other dNTP) polymérase/NS5
SAH méthyltransférase / NS5
chalcone 4 CXCL12
ANA-12 TrkB
bisacodyl First described as cytotoxic to glioblastoma quiescent cells. Supposed to target WNK1 kinase pathway
PP-13 Tubuline colchicine site
LPI 805 NK2R tachykinin receptor
Liminib or Pyr1 Lim Kinase
ET-D5 Protein Phosphatase 1
Pyridocarbazole CK2-compound 18 CK2
C1 Aurora kinases A/B
Retro-2.1 intracellular pathogens
Daunorubicin First identified as inhibiting MNBL1 and RNA (Muscleblind 1)
LIT-927 CXCL12 ligand
GPN 136 CCL22
GPN 279 CCL17
cpd14 CCR5 ago CCR5
SRN 927 CXCL12
2-amino-7-phenyldihydroquinazoline unknown
M-030-E05 E05 se fixe sur une protéine mitochondriale appelée apoptosis-inducing factor (AIF, 57kDa).
X55 inhibition of CDA-deficient tumor cells
TB001 TrkB
SR-FB-MPSBS018 haspin
LIT-001 Oxytocin receptor
tamoxifen CDK5/p25
meriolin 3 Multitarget inhibitor of Cyclin-Dependent Kinases (CDKs)
indirubins: 6-bromoindirubin-3'-oxime (BIO) GSK-3 (primary target)
DD264 human DHODH
IPPA17-A04 or IPP/CNRS-A017 human DHODH
A1B1C3_2 glycerolipid synthase Toxoplasma gondii
A51B1C1_1 Glycerolipids synthases
GAC50 human DHODH
sr7575 not known
MSK-1 inhibitor (4-(2-Chlorophenyl)-1H- benzo[d]imidazol-2-amine Hydrobromide) MSK-1 (Mitogen- and Stress-Activated Kinase 1)
CRCM5484 Bromodomain and extra-terminal (BET) bromodomains proteins with a 475-fold selectivity for the second bromodomain of the BRD3 protein (BRD3-BDII) over its first bromodomain (BRD3-BDI)