Target nature :
CXCL12 ligand
CAS n° :
2172879-52-4
Mecanism of action :
neutralizes CXCL12
Physico-chemical properties :
Locally and Orally Active CXCL12 Neutraligand with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
Probe availability :
Laboratory of therapeutic innovation, Illkirch
Princeps reference :
Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D, Haiech J, Knehans T, Rognan D, Heissler D, Marsol C, Villa P, Galzi JL, Hibert M, Frossard N, Bonnet D (2018) Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia J Med Chem 13;61(17):7671-7686.
More bibliography :
Other available information on the probe :
Orally active
solubility > 300 µM
Other information on the target :
anti-inflammatory effect of the ligand
Selectivity profile :
unknown
In vivo data :
Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
In vitro data :
Binds to CXCL12
Anti-inflammatory effect
Toxicity :
low toxicity
Chaine SMILES :
COc3cc(c2cc(c1ccc(Cl)cc1)[nH]c(=O)n2)ccc3O
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