General information
CAS n°
2172879-52-4
Mechanism of action
neutralizes CXCL12
Physico-chemical properties
Locally and Orally Active CXCL12 Neutraligand with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
Probe availability
Laboratory of therapeutic innovation, Illkirch
Princeps reference
Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D, Haiech J, Knehans T, Rognan D, Heissler D, Marsol C, Villa P, Galzi JL, Hibert M, Frossard N, Bonnet D (2018) Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia J Med Chem 13;61(17):7671-7686.
Other available information on the probe
Orally active
solubility > 300 µM
Other information on the target
anti-inflammatory effect of the ligand
Selectivity profile
unknown
In vivo data
Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
In vitro data
Binds to CXCL12
Anti-inflammatory effect
Toxicity
low toxicity
Chaine SMILES
COc3cc(c2cc(c1ccc(Cl)cc1)[nH]c(=O)n2)ccc3O