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Retro-2.1

Target nature : intracellular pathogens
CAS n° : 1510796-66-3
Mecanism of action : retrograde pathway inhibition
Physico-chemical properties : -
Probe availability : CEA/DRF/JOLIOT/SCBM
Princeps reference : N-​Methyldihydroquinazolinone Derivatives of Retro-​2 with Enhanced Efficacy against Shiga Toxin Noel, Romain; Gupta, Neetu; Pons, Valerie; Goudet, Amelie; Garcia-Castillo, Maria Daniela; Michau, Aurelien; Martinez, Jennifer; Buisson, David-Alexandre; Johannes, Ludger; Gillet, Daniel; et al Journal of Medicinal Chemistry (2013), 56(8), 3404-3413.
More bibliography : Antiviral effect of Retro-​2.1 against Herpes Simplex Virus Type 2 in vitro Dai, Wenwen; Wu, Yu; Bi, Jinpeng; Wang, Jingyu; Wang, Shuai; Kong, Wei; Barbier, Julien; Cintrat, Jean-Christophe; Gao, Feng; Jiang, Zhengran; et al Journal of Microbiology and Biotechnology (2018), 28(6), 849-859. Inhibition of retrograde transport limits polyomavirus infection in vivo Maru, Saumya; Jin, Ge; Desai, Dhimant; Amin, Shantu; Shwetank; Lauver, Matthew D.; Lukacher, Aron E. mSphere (2017), 2(6), 1-12. Retro-​2 and its dihydroquinazolinone derivatives inhibit filovirus infection Shtanko, Olena; Sakurai, Yasuteru; Reyes, Ann N.; Noel, Romain; Cintrat, Jean-Christophe; Gillet, Daniel; Barbier, Julien; Davey, Robert A. Antiviral Research (2018), 149, 154-163. Antiviral effects of Retro-​2cycl and Retro-​2.1 against Enterovirus 71 in vitro and in vivo Dai, Wenwen; Wu, Yu; Bi, Jinpeng; Lu, Xiaotong; Hou, Ali; Zhou, Yan; Sun, Bo; Kong, Wei; Barbier, Julien; Cintrat, Jean-Christophe; et al Antiviral Research (2017), 144, 311-321. (S)​-​N-​Methyldihydroquinazolinones are the Active Enantiomers of Retro-​2 Derived Compounds against Toxins Gupta, Neetu; Pons, Valerie; Noel, Romain; Buisson, David-Alexandre; Michau, Aurelien; Johannes, Ludger; Gillet, Daniel; Barbier, Julien; Cintrat, Jean-Christophe ACS Medicinal Chemistry Letters (2014), 5(1), 94-97.
Other available information on the probe : -
Other information on the target : -
Selectivity profile : -
In vivo data : -
In vitro data : -
Toxicity : -
Chaine SMILES : Cc5nc(c4ccc(C2N(C)c1ccc(F)cc1C(=O)N2c3ccccc3)s4)cs5
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