A post-doctoral position is currently available in the Cellular and Chemical Biology unit (U1143 INSERM ¿ UMR3666 CNRS; http://minilien.curie.fr/89q4ev), in the Endocytic Trafficking and Intracellular Delivery team of Dr. Ludger Johannes, in tight collaboration with the Chemical Biology of Cancer team of Dr. Raphaël Rodriguez. The candidate will test different approaches to conjugate chemical compounds with immunomodulatory properties to STxB. The program will begin with small molecules; upon success, other entities such as nucleic acids will be designed to be grafted to STxB.
Basophils are rare immune cells expressed in the human body. They are involved in several biological functions, such as defence against helminth parasite and connection between the innate and adaptive immune compartments. However, because of their rapid activation in reaction to a wide range of stimuli, they are directly involved in pathogenic processes such as atopic/allergic and inflammatory processes, in both respiratory and skin systems (asthma, rhinitis, urticaria, etc¿). It has been shown that the IL3 cytokine is a key protein in the activation of basophils processes and inflammatory response. Thus, the candidate will study IL3 cytokine in order to develop small molecules targeting the protein. Bioinformatics analysis, molecular dynamics simulations and drug design approaches will be used for the design of inhibitors of the IL3 pathway, in order to suppress basophil activation under pathological conditions. The project is financially supported by the ANR (Agence Nationale pour la Recherche, BASIN project, ANR-19-CE17-0021) and involves collaboration with several experimental labs.