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LIT-927

Target nature : CXCL12 ligand
CAS n° : 2172879-52-4
Mecanism of action : neutralizes CXCL12
Physico-chemical properties : Locally and Orally Active CXCL12 Neutraligand with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
Probe availability : Laboratory of therapeutic innovation, Illkirch
Princeps reference : Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D, Haiech J, Knehans T, Rognan D, Heissler D, Marsol C, Villa P, Galzi JL, Hibert M, Frossard N, Bonnet D (2018) Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia J Med Chem 13;61(17):7671-7686.
More bibliography :
Other available information on the probe : Orally active solubility > 300 µM
Other information on the target : anti-inflammatory effect of the ligand
Selectivity profile : unknown
In vivo data : Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia
In vitro data : Binds to CXCL12 Anti-inflammatory effect
Toxicity : low toxicity
Chaine SMILES : COc3cc(c2cc(c1ccc(Cl)cc1)[nH]c(=O)n2)ccc3O
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