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A post-doctoral position in the DSIMB (Dynamique des Structures et Interfaces des Macromolécules Biologiques) team

General informations

Lieu : UMR S_1134 « Integrated Biology of Red Blood Cell » (Inserm- University of Paris))
Type de contrat : Post-doctoral
Quotité de travail : 100
Employeur : INSERM
Rémunération : na
Date d'embauche prévue : 2020-03-22
Durée du contrat : 2 years
Missions/Activités : Basophils are rare immune cells expressed in the human body. They are involved in several biological functions, such as defence against helminth parasite and connection between the innate and adaptive immune compartments. However, because of their rapid activation in reaction to a wide range of stimuli, they are directly involved in pathogenic processes such as atopic/allergic and inflammatory processes, in both respiratory and skin systems (asthma, rhinitis, urticaria, etc…). It has been shown that the IL3 cytokine is a key protein in the activation of basophils processes and inflammatory response. Thus, the candidate will study IL3 cytokine in order to develop small molecules targeting the protein. Bioinformatics analysis, molecular dynamics simulations and drug design approaches will be used for the design of inhibitors of the IL3 pathway, in order to suppress basophil activation under pathological conditions. The project is financially supported by the ANR (Agence Nationale pour la Recherche, BASIN project, ANR-19-CE17-0021) and involves collaboration with several experimental labs.

Compétences

Niveau d'études souhaité : PhD. in bioinformatics or computational biology.
Compétences souhaitées : excellent skills in bioinformatics, numerical simulations and drug design approaches; strong communication skills and be ready to work in close collaboration with experimentalist partners

Divers

Contact

Lastname : Diharce
Email : julien.diharce@u-paris.fr