Postdoctoral position in organic chemistry/medicinal chemistry

Lieu : CEA-Saclay, Department of bioorganic chemistry and isotopic labeling, Gif sur Yvette

Type de contrat : postdoctoral fellow

Quotité de travail : 100

Employeur : CEA

Rémunération : 2100-2300€ net per month

Date d'embauche prévue : 2022-03-01

Durée du contrat : 12 months

Missions/Activités : In the frame of a collaborative project aiming at discovering new binders for neurodegenerative diseases, our group is developing new labelling technologies, combinatorial chemistry and high throughput screening for application in nuclear imaging (see Angew. Chem. Int. Ed. 2018, 57, 9744; Chem. Commun. 2021, DOI: 10.1039/D1CC02665H). The project aims to develop new combinatorial synthetic approaches to prepare libraries of molecules which will be used to accelerate the discovery of new ligands able to selectively bind protein aggregates involved in Alzheimer, Parkinson and Huntington diseases. The strategy is based on Click Chemistry combined with a mass enhancer and radiolabeling, to identify specific ligands for neurodegenerative diseases and map their distribution by imaging. The postdoctoral fellow will be hosted in the SCBM (Service de Chimie Bioorganique et de Marquage) at CEA-Saclay and will work in close collaboration with several teams within the network. All experiments will be conducted with stable isotopes. CEA personnel will perform experiments with radiolabeled compounds.

Niveau d'études souhaité : PhD in organic chemistry

Compétences souhaitées : With a strong scientific record, a high motivation. Good verbal and written communication skills and a flair for teamwork are required. The candidate should be autonomous and may have to supervise PhD students and Master students.

Autres informations : applicants should send their CV with a list of current publications, a cover letter motivating their interest in the position and the names and addresses of two referees to eugenie.romero@cea.fr and frederic.taran@cea.fr . The selected candidate is expected to start in March 2022. Applications are considered from now, until the position is filled.

Lastname : Dr Romero et Dr Taran

Email : eugenie.romero@cea.fr + mailto:frederic.taran@cea.fr