Target nature :
First described as cytotoxic to glioblastoma quiescent cells. Supposed to target WNK1 kinase pathway
CAS n° :
603-50-9
Mecanism of action :
Acting through WNK1 sérine/thréonine protéine kinase signaling pathway
Physico-chemical properties :
Practically insoluble in water and alkaline solvents. Soluble in acids, alcohol, acetone, propylene glycol and other organic solvents.\r\nC22H19NO4
Probe availability :
Available to Prestwick Chemical company : http://www.prestwickchemical.com/index.html
Princeps reference :
Zeniou M et al (2015) Chemical library screening and structure-function relationship studies identify bisacodyl as a potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like cells. PlosOne PLoS ONE 09/2015; 10(8): e013479
More bibliography :
- Zeniou M et al (2015) Chemical library screening and structure-function relationship studies identify bisacodyl as a potent and selective cytotoxic agent towards quiescent human glioblastoma tumor stem-like cells. PlosOne PLoS ONE 09/2015; 10(8): e013479\r\n- Dong J et al (2016) Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling. Biochim Biophys Acta. 2017 Biochim Biophys Acta. 2017 Jun;1864(6):1018-1027.\r\n - Chen W. et al (2018) WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling. Oncotarget, 2018, Vol. 9, (No. 43): 27197-27219
Other available information on the probe :
Powder can be stored at room temperature
Other information on the target :
not known
Selectivity profile :
not lnown
In vivo data :
Bisacodyl is a synthetic pyridinylmethylene-diacetate ester derivative stimulant laxative, Bisacodyl acts with a parasympathetic effect directly on mucosal sensory nerves, increasing peristaltic contractions. It is used for occasional constipation, in pre- and postoperative treatment, and in conditions that require facilitation of defecation. (NCI04)
In vitro data :
Acting through WNK1 sérine/thréonine protéine kinase signaling pathway
Toxicity :
Toxic on glioblastoma quiescent cells\r\nOther toxicity information can be found here: https://pubchem.ncbi.nlm.nih.gov/compound/2391#section=NIOSH-Toxicity-Data
Chaine SMILES :
CC(=O)Oc3ccc(C(c1ccc(OC(C)=O)cc1)c2ccccn2)cc3
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