Gonçalves, Antonio and Maisonnasse, Pauline and Donati, Flora and Albert, Mélanie and Behillil, Sylvie and Contreras, Vanessa and Naninck, Thibaut and Marlin, Romain and Solas, Caroline and Pizzorno, Andres and Lemaitre, Julien and Kahlaoui, Nidhal and Terrier, Olivier and Ho Tsong Fang, Raphael and Enouf, Vincent and Dereuddre-Bosquet, Nathalie and Brisebarre, Angela and Touret, Franck and Chapon, Catherine and Hoen, Bruno and Lina, Bruno and Rosa Calatrava, Manuel and de Lamballerie, Xavier and Mentré, France and Le Grand, Roger and van der Werf, Sylvie and Guedj, Jérémie

SARS-CoV-2 viral dynamics in non-human primates

PLOS Computational Biology (2021)

17, e1008785

10.1371/JOURNAL.PCBI.1008785

Touret, Franck and Luciani, Léa and Baronti, Cécile and Cochin, Maxime and Driouich, Jean-Sélim and Gilles, Magali and Thirion, Laurence and Nougairède, Antoine and de Lamballerie, Xavier

Replicative Fitness of a SARS-CoV-2 20I/501Y.V1 Variant from Lineage B.1.1.7 in Human Reconstituted Bronchial Epithelium

mBio (2021)

12,

10.1128/MBIO.00850-21

Abuduaini, Tuniyazi and Roy, Vincent and Marlet, Julien and Gaudy-Graffin, Catherine and Brand, Denys and Baronti, Cécile and Touret, Franck and Coutard, Bruno and McBrayer, Tamara R. and Schinazi, Raymond F. and Agrofoglio, Luigi A.

Synthesis and Antiviral Evaluation of (1,4-Disubstituted-1,2,3-Triazol)-(E)-2-Methyl-but-2-Enyl Nucleoside Phosphonate Prodrugs

Molecules (2021)

26, 1493

10.3390/MOLECULES26051493

Driouich, Jean-Sélim and Cochin, Maxime and Lingas, Guillaume and Moureau, Grégory and Touret, Franck and Petit, Paul-Rémi and Piorkowski, Géraldine and Barthélémy, Karine and Laprie, Caroline and Coutard, Bruno and Guedj, Jérémie and de Lamballerie, Xavier and Solas, Caroline and Nougairède, Antoine

Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model

Nature Communications (2021)

12,

10.1038/S41467-021-21992-W

Touret, Franck and Driouich, Jean-Sélim and Cochin, Maxime and Petit, Paul Rémi and Gilles, Magali and Barthélémy, Karine and Moureau, Grégory and Mahon, Francois-Xavier and Malvy, Denis and Solas, Caroline and de Lamballerie, Xavier and Nougairède, Antoine

Preclinical evaluation of Imatinib does not support its use as an antiviral drug against SARS-CoV-2

Antiviral Research (2021)

193, 105137

10.1016/J.ANTIVIRAL.2021.105137

Mathieu, Cyrille and Touret, Franck and Jacquemin, Clémence and Janin, Yves L. and Nougairède, Antoine and Brailly, Manon and Mazelier, Magalie and Décimo, Didier and Vasseur, Virginie and Hans, Aymeric and Valle-Casuso, José-Carlos and de Lamballerie, Xavier and Horvat, Branka and André, Patrice and Si-Tahar, Mustapha and Lotteau, Vincent and Vidalain, Pierre-Olivier

A Bioluminescent 3CLPro Activity Assay to Monitor SARS-CoV-2 Replication and Identify Inhibitors

Viruses (2021)

13, 1814

10.3390/V13091814

Kaptein, Suzanne J. F. and Goethals, Olivia and Kiemel, Dominik and Marchand, Arnaud and Kesteleyn, Bart and Bonfanti, Jean-François and Bardiot, Dorothée and Stoops, Bart and Jonckers, Tim H. M. and Dallmeier, Kai and Geluykens, Peggy and Thys, Kim and Crabbe, Marjolein and Chatel-Chaix, Laurent and Münster, Max and Querat, Gilles and Touret, Franck and de Lamballerie, Xavier and Raboisson, Pierre and Simmen, Kenny and Chaltin, Patrick and Bartenschlager, Ralf and Van Loock, Marnix and Neyts, Johan

A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction

Nature (2021)

598, 504-509

10.1038/S41586-021-03990-6

Cochin, Maxime and Touret, Franck and Driouich, Jean-Sélim and Moureau, Gregory and Petit, Paul-Rémi and Laprie, Caroline and Solas, Caroline and de Lamballerie, Xavier and Nougairède, Antoine

Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model

Antiviral Research (2022)

197, 105212

10.1016/J.ANTIVIRAL.2021.105212

Weiss, Anne and Touret, Franck and Baronti, Cecile and Gilles, Magali and Hoen, Bruno and Nougairède, Antoine and de Lamballerie, Xavier and Sommer, Morten O. A.

Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2)

PLOS ONE (2021)

16, e0260958

10.1371/JOURNAL.PONE.0260958

Mélade, Julien and Piorkowski, Géraldine and Touret, Franck and Fourié, Toscane and Driouich, Jean-Sélim and Cochin, Maxime and Bouzidi, Hawa Sophia and Coutard, Bruno and Nougairède, Antoine and de Lamballerie, Xavier

A simple reverse genetics method to generate recombinant coronaviruses

EMBO reports (2022)

23,

10.15252/EMBR.202153820

Touret, Franck and Baronti, Cécile and Bouzidi, Hawa Sophia and de Lamballerie, Xavier

In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolate

Scientific Reports (2022)

12,

10.1038/S41598-022-08559-5

Driouich, Jean-Sélim and Cochin, Maxime and Touret, Franck and Petit, Paul-Rémi and Gilles, Magali and Moureau, Grégory and Barthélémy, Karine and Laprie, Caroline and Wattanakul, Thanaporn and Chotsiri, Palang and Hoglund, Richard M. and Tarning, Joel and Fraisse, Laurent and Sjö, Peter and Mowbray, Charles E. and Escudié, Fanny and Scandale, Ivan and Chatelain, Eric and de Lamballerie, Xavier and Solas, Caroline and Nougairède, Antoine

Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2

eBioMedicine (2022)

82, 104148

10.1016/J.EBIOM.2022.104148

Garnier, Anne and Bork, Nadja I. and Jacquet, Eric and Zipfel, Svante and Muñoz-Guijosa, Christian and Baczkó, Istvan and Reichenspurner, Hermann and Donzeau-Gouge, Patrick and Maier, Lars S. and Dobrev, Dobromir and Girdauskas, Evaldas and Nikolaev, Viacheslav O. and Fischmeister, Rodolphe and Molina, Cristina E.

Mapping genetic changes in the cAMP-signaling cascade in human atria

Journal of Molecular and Cellular Cardiology (2021)

155, 10-20

10.1016/J.YJMCC.2021.02.006

Shikura, Noriyasu and Darbon, Emmanuelle and Esnault, Catherine and Deniset-Besseau, Ariane and Xu, Delin and Lejeune, Clara and Jacquet, Eric and Nhiri, Naima and Sago, Laila and Cornu, David and Werten, Sebastiaan and Martel, Cécile and Virolle, Marie-Joelle

The Phosin PptA Plays a Negative Role in the Regulation of Antibiotic Production in Streptomyces lividans

Antibiotics (2021)

10, 325

10.3390/ANTIBIOTICS10030325

Condamina, Morgane and Penso, Laetitia and Tran, Viet-Thi and Hotz, Claire and Guillem, Philippe and Villani, Axel Patrice and Perrot, Pierre and Bru, Marie-France and Jacquet, Eric and Nassif, Aude and Bachelez, Hervé and Wolkenstein, Pierre and Beylot-Barry, Marie and Richard, Marie-Aleth and Ravaud, Philippe and Viguier, Manuelle and Sbidian, Emilie

Baseline Characteristics of a National French E-Cohort of Hidradenitis Suppurativa in ComPaRe and Comparison with Other Large Hidradenitis Suppurativa Cohorts

Dermatology (2021)

237, 748-758

10.1159/000513447

Zhao, Guangkuan and Bignon, Jerôme and Levaique, Helène and Dubois, Joëlle and Alami, Mouad and Provot, Olivier

One-Pot Synthesis of 2-Styrylindoles from Ortho-Substituted Chloroenynes

The Journal of Organic Chemistry (2018)

83, 15323-15332

10.1021/ACS.JOC.8B02563

Gicquel, Maxime and Gomez, Catherine and Garcia Alvarez, Maria Concepcion and Pamlard, Olivier and Guérineau, Vincent and Jacquet, Eric and Bignon, Jérôme and Voituriez, Arnaud and Marinetti, Angela

Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3'-Spirocyclopentene Oxindole Derivatives

Journal of Medicinal Chemistry (2018)

61, 9386-9392

10.1021/ACS.JMEDCHEM.8B01137

Nguyen, Tra-Ly and Nokin, Marie-Julie and Egorov, Maxim and Tomé, Mercedes and Bodineau, Clément and Di Primo, Carmelo and Minder, Lætitia and Wdzieczak-Bakala, Joanna and Garcia-Alvarez, Maria Concepcion and Bignon, Jérôme and Thoison, Odile and Delpech, Bernard and Surpateanu, Georgiana and Frapart, Yves-Michel and Peyrot, Fabienne and Abbas, Kahina and Terés, Silvia and Evrard, Serge and Khatib, Abdel-Majid and Soubeyran, Pierre and Iorga, Bogdan I. and Durán, Raúl V. and Collin, Pascal

mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells

Cancer Research (2018)

78, 5384-5397

10.1158/0008-5472.CAN-18-0232

Lamaa, Diana and Lin, Hsin-Ping and Zig, Lena and Bauvais, Cyril and Bollot, Guillaume and Bignon, Jérôme and Levaique, Helene and Pamlard, Olivier and Dubois, Joelle and Ouaissi, Mehdi and Souce, Martin and Kasselouri, Athena and Saller, François and Borgel, Delphine and Jayat-Vignoles, Chantal and Al-Mouhammad, Hazar and Feuillard, Jean and Benihoud, Karim and Alami, Mouad and Hamze, Abdallah

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4

Journal of Medicinal Chemistry (2018)

61, 6574-6591

10.1021/ACS.JMEDCHEM.8B00050

Abou Samra, Alma and Robert, Aude and Gov, Crystal and Favre, Loëtitia and Eloy, Laure and Jacquet, Eric and Bignon, Jérôme and Wiels, Joëlle and Desrat, Sandy and Roussi, Fanny

Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A

European Journal of Medicinal Chemistry (2018)

148, 26-38

10.1016/J.EJMECH.2018.01.100

Naret, Timothée and Bignon, Jérôme and Bernadat, Guillaume and Benchekroun, Mohamed and Levaique, Helene and Lenoir, Christine and Dubois, Joelle and Pruvost, Alain and Saller, François and Borgel, Delphine and Manoury, Boris and Leblais, Veronique and Darrigrand, Romain and Apcher, Sébastien and Brion, Jean-Daniel and Schmitt, Etienne and Leroux, Frédéric R. and Alami, Mouad and Hamze, Abdallah

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation

European Journal of Medicinal Chemistry (2018)

143, 473-490

10.1016/J.EJMECH.2017.11.055

Samson, Camille and Petitalot, Ambre and Celli, Florian and Herrada, Isaline and Ropars, Virginie and Le Du, Marie-Hélène and Nhiri, Naïma and Jacquet, Eric and Arteni, Ana-Andrea and Buendia, Brigitte and Zinn-Justin, Sophie

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases

Nucleic Acids Research (2018)

46, 10460-10473

10.1093/NAR/GKY736

Rochat, Tatiana and Bohn, Chantal and Morvan, Claire and Le Lam, Thao Nguyen and Razvi, Fareha and Pain, Adrien and Toffano-Nioche, Claire and Ponien, Prishila and Jacq, Annick and Jacquet, Eric and Fey, Paul D and Gautheret, Daniel and Bouloc, Philippe

The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus

Nucleic Acids Research (2018)

46, 8803-8816

10.1093/NAR/GKY584

Grzela, Renata and Nusbaum, Julien and Fieulaine, Sonia and Lavecchia, Francesco and Desmadril, Michel and Nhiri, Naima and Van Dorsselaer, Alain and Cianferani, Sarah and Jacquet, Eric and Meinnel, Thierry and Giglione, Carmela

Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics (2018)

1866, 348-355

10.1016/J.BBAPAP.2017.10.007

Molina, Cristina E and Jacquet, Eric and Ponien, Prishila and Muñoz-Guijosa, Christian and Baczkó, Istvan and Maier, Lars S and Donzeau-Gouge, Patrick and Dobrev, Dobromir and Fischmeister, Rodolphe and Garnier, Anne

Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart

Cardiovascular Research (2018)

114, 247-258

10.1093/CVR/CVX182

El-Khoury, Flaria and Bignon, Jérôme and Martin, Jean-René

jouvence, a new human snoRNA involved in the control of cell proliferation

BMC Genomics (2020)

21,

10.1186/S12864-020-07197-3

El Abbouchi, Abdelmoula and El Brahmi, Nabil and Hiebel, Marie-Aude and Bignon, Jérôme and Guillaumet, Gérald and Suzenet, Franck and El Kazzouli, Saïd

Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents

Bioorganic & Medicinal Chemistry Letters (2020)

30, 127426

10.1016/J.BMCL.2020.127426

Campos, Pierre-Eric and Herbette, Gaëtan and Chendo, Christophe and Clerc, Patricia and Tintillier, Florent and de Voogd, Nicole J. and Papanagnou, Eleni-Dimitra and Trougakos, Ioannis P. and Jerabek, Moran and Bignon, Jérôme and Le Goff, Géraldine and Ouazzani, Jamal and Gauvin-Bialecki, Anne

Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp.

Marine Drugs (2020)

18, 350

10.3390/MD18070350

Khelifi, Ilhem and Pecnard, Shannon and Bernadat, Guillaume and Bignon, Jérome and Levaique, Hélène and Dubois, Joëlle and Provot, Olivier and Alami, Mouad

Synthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuines

ChemMedChem (2020)

15, 1571-1578

10.1002/CMDC.202000197

Chen, Liang and Fan, Yu and Qiu, Jieru and Laurent, Régis and Li, Jin and Bignon, Jérôme and Mignani, Serge and Caminade, Anne-Marie and Shi, Xiangyang and Majoral, Jean-Pierre

Potent Anticancer Efficacy of First-In-Class CuII and AuIII Metaled Phosphorus Dendrons with Distinct Cell Death Pathways

Chemistry - A European Journal (2020)

26, 5903-5910

10.1002/CHEM.202001014

Péresse, Tiphaine and Kovacs, David and Subra, Mélody and Bigay, Joëlle and Tsai, Meng-Chen and Polidori, Joël and Gautier, Romain and Desrat, Sandy and Fleuriot, Lucile and Debayle, Delphine and Litaudon, Marc and Pham, Van-Cuong and Bignon, Jérôme and Antonny, Bruno and Roussi, Fanny and Mesmin, Bruno

Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor

Journal of Biological Chemistry (2020)

295, 4277-4288

10.1074/JBC.RA119.012012

Gapil Tiamas, Shelly and Daressy, Florian and Abou Samra, Alma and Bignon, Jérome and Steinmetz, Vincent and Litaudon, Marc and Fourneau, Christophe and Hoong Leong, Kok and Ariffin, Azhar and Awang, Khalijah and Desrat, Sandy and Roussi, Fanny

Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2

Bioorganic & Medicinal Chemistry Letters (2020)

30, 127003

10.1016/J.BMCL.2020.127003

Chevreuil, Maelenn and Lecoq, Lauriane and Wang, Shishan and Gargowitsch, Laetitia and Nhiri, Naïma and Jacquet, Eric and Zinn, Thomas and Fieulaine, Sonia and Bressanelli, Stéphane and Tresset, Guillaume

Nonsymmetrical Dynamics of the HBV Capsid Assembly and Disassembly Evidenced by Their Transient Species

The Journal of Physical Chemistry B (2020)

124, 9987-9995

10.1021/ACS.JPCB.0C05024

Munoz-Montesino, Carola and Larkem, Djabir and Barbereau, Clément and Igel-Egalon, Angélique and Truchet, Sandrine and Jacquet, Eric and Nhiri, Naïma and Moudjou, Mohammed and Sizun, Christina and Rezaei, Human and Béringue, Vincent and Dron, Michel

A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP

Journal of Biological Chemistry (2020)

295, 14025-14039

10.1074/JBC.RA120.014738

Rivière, Gwladys and Oueslati, Saoussen and Gayral, Maud and Créchet, Jean-Bernard and Nhiri, Naïma and Jacquet, Eric and Cintrat, Jean-Christophe and Giraud, François and van Heijenoort, Carine and Lescop, Ewen and Pethe, Stéphanie and Iorga, Bogdan I. and Naas, Thierry and Guittet, Eric and Morellet, Nelly

NMR Characterization of the Influence of Zinc(II) Ions on the Structural and Dynamic Behavior of the New Delhi Metallo-ß-Lactamase-1 and on the Binding with Flavonols as Inhibitors

ACS Omega (2020)

5, 10466-10480

10.1021/ACSOMEGA.0C00590

Zhang, Kena and El Bouakher, Abderrahman and Levaique, Helene and Bignon, Jerome and Retailleau, Pascal and Alami, Mouad and Hamze, Abdallah

Pyrrolo-imidazo[1,2-a]pyridine Scaffolds through a Sequential Coupling of N-Tosylhydrazones with Imidazopyridines and Reductive Cadogan Annulation, Synthetic Scope, and Application

The Journal of Organic Chemistry (2019)

84, 13807-13823

10.1021/ACS.JOC.9B02018

Khelifi, Ilhem and Naret, Timothée and Hamze, Abdallah and Bignon, Jérome and Levaique, Hélène and Garcia Alvarez, Maria Concepcion and Dubois, Joëlle and Provot, Olivier and Alami, Mouad

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents

European Journal of Medicinal Chemistry (2019)

168, 176-188

10.1016/J.EJMECH.2019.02.038

Grima, Brigitte and Papin, Christian and Martin, Béatrice and Chélot, Elisabeth and Ponien, Prishila and Jacquet, Eric and Rouyer, François

PERIOD-controlled deadenylation of the timeless transcript in the Drosophila circadian clock

Proceedings of the National Academy of Sciences (2019)

116, 5721-5726

10.1073/PNAS.1814418116

Jaïs, Philippe H and Decroly, Etienne and Jacquet, Eric and Le Boulch, Marine and Jaïs, Aurélien and Jean-Jean, Olivier and Eaton, Heather and Ponien, Prishila and Verdier, Fréderique and Canard, Bruno and Goncalves, Sergio and Chiron, Stéphane and Le Gall, Maude and Mayeux, Patrick and Shmulevitz, Maya

C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system

Nucleic Acids Research (2019)

47, 2681-2698

10.1093/NAR/GKZ069

Petitalot, Ambre and Dardillac, Elodie and Jacquet, Eric and Nhiri, Naima and Guirouilh-Barbat, Josée and Julien, Patrick and Bouazzaoui, Isslam and Bonte, Dorine and Feunteun, Jean and Schnell, Jeff A. and Lafitte, Philippe and Aude, Jean-Christophe and Noguès, Catherine and Rouleau, Etienne and Lidereau, Rosette and Lopez, Bernard S. and Zinn-Justin, Sophie and Caputo, Sandrine M.

Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact ofBRCA1BRCT Variants on Cancer Risk

Molecular Cancer Research (2019)

17, 54-69

10.1158/1541-7786.MCR-17-0357

Loeuillet, Corinne and Touquet, Bastien and Guichou, Jean François and Labesse, Gilles and Sereno, Denis

A Tiny Change Makes a Big Difference in the Anti-Parasitic Activities of an HDAC Inhibitor

International Journal of Molecular Sciences (2019)

20, 2973

10.3390/IJMS20122973

Schneider, Melanie and Pons, Jean-Luc and Labesse, Gilles

Exploring the conformational space of a receptor for drug design: An ERalpha case study

Journal of Molecular Graphics and Modelling (2021)

108, 107974

10.1016/J.JMGM.2021.107974

Jublot, Delphine and Cavaillès, Pierre and Kamche, Salima and Francisco, Denise and Fontinha, Diana and Prudêncio, Miguel and Guichou, Jean-Francois and Labesse, Gilles and Sereno, Denis and Loeuillet, Corinne

A Histone Deacetylase (HDAC) Inhibitor with Pleiotropic In Vitro Anti-Toxoplasma and Anti-Plasmodium Activities Controls Acute and Chronic Toxoplasma Infection in Mice

International Journal of Molecular Sciences (2022)

23, 3254

10.3390/IJMS23063254

Reys, Victor and Labesse, Gilles

SLiMAn: An Integrative Web Server for Exploring Short Linear Motif-Mediated Interactions in Interactomes

Journal of Proteome Research (2022)

21, 1654-1663

10.1021/ACS.JPROTEOME.1C00964

Pons, Jean-Luc and Reys, Victor and Grand, François and Moreau, Violaine and Gracy, Jerôme and Exner, Thomas E. and Labesse, Gilles

TOME 3.0: Interfacing Protein Structure Modeling and Ligand Docking

Journal of Molecular Biology (2024)

436, 168704

10.1016/J.JMB.2024.168704

Bourguignon, Tom and Godinez-Leon, Jesus Alfredo and Pochet, Amine and Shamsuddin, Tahmida and Sencio, Valentin and Chatagnon, Jonathan and Grandé, Axelle and Fine, Joan and Heumel, Séverine and Robil, Cyril and Delval, Lou and Piveteau, Catherine and Belouzard, Sandrine and Brodin, Priscille and Trottein, François and Machelart, Arnaud and Gref, Ruxandra

Pulmonary delivery of clofoctol-loaded nanoparticles inhibits SARS-CoV-2 replication and reduces pneumonia

International Journal of Pharmaceutics (2025)

677, 125634

10.1016/J.IJPHARM.2025.125634

Gedeon, Antoine and Yab, Emilie and Dinut, Aurelia and Sadowski, Elodie and Capton, Estelle and Dreneau, Aurore and Petit, Julienne and Gioia, Bruna and Piveteau, Catherine and Djaout, Kamel and Lecat, Estelle and Wehenkel, Anne Marie and Gubellini, Francesca and Mechaly, Ariel and Alzari, Pedro M. and Deprez, Benoît and Baulard, Alain and Aubry, Alexandra and Willand, Nicolas and Petrella, Stéphanie

Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase

iScience (2024)

27, 110967

10.1016/J.ISCI.2024.110967

Vieira Da Cruz, Anais and Jiménez-Castellanos, Juan-Carlos and Börnsen, Clara and Van Maele, Laurye and Compagne, Nina and Pradel, Elizabeth and Müller, Reinke T and Meurillon, Virginie and Soulard, Daphnée and Piveteau, Catherine and Biela, Alexandre and Dumont, Julie and Leroux, Florence and Deprez, Benoit and Willand, Nicolas and Pos, Klaas M and Frangakis, Achilleas S and Hartkoorn, Ruben C and Flipo, Marion

Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae

EMBO Molecular Medicine (2023)

16, 93-111

10.1038/S44321-023-00007-9

Gioia, Bruna and Ruggieri, Francesca and Biela, Alexandre and Landry, Valérie and Roussel, Pascal and Piveteau, Catherine and Leroux, Florence and Hartkoorn, Ruben C. and Willand, Nicolas

Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis

International Journal of Molecular Sciences (2023)

24, 17395

10.3390/IJMS242417395

Songue Same, Olivier and Nobosse, Pierre and Ngolong Ngea, Guillaume Legrand and Piveteau, Catherine and Lemdani, Mohamed and Kamga, Richard and Deprez, Benoit

Migration study of phthalates from non-food plastic containers used in food preservation

Heliyon (2023)

9, e20002

10.1016/J.HELIYON.2023.E20002

Picon, Sylvain and Boulahjar, Rajaa and Hoguet, Vanessa and Baron, Morgane and Duplan, Isabelle and Vallez, Emmanuelle and Hennuyer, Nathalie and Dumont, Julie and Touche, Véronique and Dorchies, Emilie and Lasalle, Manuel and Descat, Amandine and Piveteau, Catherine and Biela, Alexandre and Chaput, Ludovic and Villoutreix, Bruno O. and Lipka, Emmanuelle and Sevin, Emmanuel and Culot, Maxime and Gosselet, Fabien and Lestavel, Sophie and Roussel, Pascal and Deprez-Poulain, Rebecca and Leroux, Florence and Staels, Bart and Deprez, Benoit and Tailleux, Anne and Charton, Julie

Discovery, Structure-Activity Relationships, and In Vivo Activity of Dihydropyridone Agonists of the Bile Acid Receptor TGR5

Journal of Medicinal Chemistry (2023)

66, 11732-11760

10.1021/ACS.JMEDCHEM.2C01881

Compagne, Nina and Jiménez-Castellanos, Juan-Carlos and Meurillon, Virginie and Pradel, Elizabeth and Vieira Da Cruz, Anais and Piveteau, Catherine and Biela, Alexandre and Eveque, Maxime and Leroux, Florence and Deprez, Benoit and Willand, Nicolas and Hartkoorn, Ruben C. and Flipo, Marion

Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump

European Journal of Medicinal Chemistry (2023)

259, 115630

10.1016/J.EJMECH.2023.115630

Tangara, Salia and Faïon, Léo and Piveteau, Catherine and Capet, Frédéric and Godelier, Romain and Michel, Marion and Flipo, Marion and Deprez, Benoit and Willand, Nicolas and Villemagne, Baptiste

Rapid and Efficient Access to Novel Bio-Inspired 3-Dimensional Tricyclic SpiroLactams as Privileged Structures via Meyers' Lactamization

Pharmaceuticals (2023)

16, 413

10.3390/PH16030413

Faïon, Léo and Djaout, Kamel and Pintiala, Catalin and Piveteau, Catherine and Leroux, Florence and Biela, Alexandre and Slupek, Stéphanie and Antoine, Rudy and Záhorszká, Monika and Cantrelle, Francois-Xavier and Hanoulle, Xavier and Korduláková, Jana and Deprez, Benoit and Willand, Nicolas and Baulard, Alain R. and Flipo, Marion

Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification

Pharmaceuticals (2023)

16, 335

10.3390/PH16030335

Brier, Lucile and Hassan, Haitham and Hanoulle, Xavier and Landry, Valerie and Moschidi, Danai and Desmarets, Lowiese and Rouillé, Yves and Dumont, Julie and Herledan, Adrien and Warenghem, Sandrine and Piveteau, Catherine and Carré, Paul and Ikherbane, Sarah and Cantrelle, François-Xavier and Dupré, Elian and Dubuisson, Jean and Belouzard, Sandrine and Leroux, Florence and Deprez, Benoit and Charton, Julie

Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses

European Journal of Medicinal Chemistry (2023)

250, 115186

10.1016/J.EJMECH.2023.115186

Dam, Sushovan and Tangara, Salia and Hamela, Claire and Hattabi, Theo and Faïon, Léo and Carre, Paul and Antoine, Rudy and Herledan, Adrien and Leroux, Florence and Piveteau, Catherine and Eveque, Maxime and Flipo, Marion and Deprez, Benoit and Kremer, Laurent and Willand, Nicolas and Villemagne, Baptiste and Hartkoorn, Ruben C.

Tricyclic SpiroLactams Kill Mycobacteria In Vitro and In Vivo by Inhibiting Type II NADH Dehydrogenases

Journal of Medicinal Chemistry (2022)

65, 16651-16664

10.1021/ACS.JMEDCHEM.2C01493

Legru, Alice and Verdirosa, Federica and Vo-Hoang, Yen and Tassone, Giusy and Vascon, Filippo and Thomas, Caitlyn A. and Sannio, Filomena and Corsica, Giuseppina and Benvenuti, Manuela and Feller, Georges and Coulon, Rémi and Marcoccia, Francesca and Devente, Savannah Rowane and Bouajila, Ezeddine and Piveteau, Catherine and Leroux, Florence and Deprez-Poulain, Rebecca and Deprez, Benoît and Licznar-Fajardo, Patricia and Crowder, Michael W. and Cendron, Laura and Pozzi, Cecilia and Mangani, Stefano and Docquier, Jean-Denis and Hernandez, Jean-François and Gavara, Laurent

Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-ß-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates

Journal of Medicinal Chemistry (2022)

65, 16392-16419

10.1021/ACS.JMEDCHEM.2C01257

Camberlein, Virgyl and Fléau, Charlotte and Sierocki, Pierre and Li, Lenong and Gealageas, Ronan and Bosc, Damien and Guillaume, Valentin and Warenghem, Sandrine and Leroux, Florence and Rosell, Melissa and Cheng, Keguang and Medve, Laura and Prigent, Mathilde and Decanter, Myriam and Piveteau, Catherine and Biela, Alexandre and Eveque, Maxime and Dumont, Julie and Mpakali, Anastasia and Giastas, Petros and Herledan, Adrien and Couturier, Cyril and Haupenthal, Jörg and Lesire, Laetitia and Hirsch, Anna K. H. and Deprez, Benoit and Stratikos, Efstratios and Bouvier, Marlene and Deprez-Poulain, Rebecca

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis

Angewandte Chemie International Edition (2022)

61,

10.1002/ANIE.202203560

Belouzard, Sandrine and Machelart, Arnaud and Sencio, Valentin and Vausselin, Thibaut and Hoffmann, Eik and Deboosere, Nathalie and Rouillé, Yves and Desmarets, Lowiese and Séron, Karin and Danneels, Adeline and Robil, Cyril and Belloy, Loic and Moreau, Camille and Piveteau, Catherine and Biela, Alexandre and Vandeputte, Alexandre and Heumel, Séverine and Deruyter, Lucie and Dumont, Julie and Leroux, Florence and Engelmann, Ilka and Alidjinou, Enagnon Kazali and Hober, Didier and Brodin, Priscille and Beghyn, Terence and Trottein, François and Deprez, Benoit and Dubuisson, Jean

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

PLOS Pathogens (2022)

18, e1010498

10.1371/JOURNAL.PPAT.1010498

Flipo, Marion and Frita, Rosangela and Bourotte, Marilyne and Martínez-Martínez, María S. and Boesche, Markus and Boyle, Gary W. and Derimanov, Geo and Drewes, Gerard and Gamallo, Pablo and Ghidelli-Disse, Sonja and Gresham, Stephanie and Jiménez, Elena and de Mercado, Jaime and Pérez-Herrán, Esther and Porras-De Francisco, Esther and Rullas, Joaquín and Casado, Patricia and Leroux, Florence and Piveteau, Catherine and Kiass, Mehdi and Mathys, Vanessa and Soetaert, Karine and Megalizzi, Véronique and Tanina, Abdalkarim and Wintjens, René and Antoine, Rudy and Brodin, Priscille and Delorme, Vincent and Moune, Martin and Djaout, Kamel and Slupek, Stéphanie and Kemmer, Christian and Gitzinger, Marc and Ballell, Lluis and Mendoza-Losana, Alfonso and Lociuro, Sergio and Deprez, Benoit and Barros-Aguirre, David and Remuiñán, Modesto J. and Willand, Nicolas and Baulard, Alain R.

The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis

Science Translational Medicine (2022)

14,

10.1126/SCITRANSLMED.AAZ6280

Kraupner, Nicolas and Dinh, Chau Phi and Wen, Xiaoan and Landry, Valérie and Herledan, Adrien and Leroux, Florence and Bosc, Damien and Charton, Julie and Maillard, Clara and Warenghem, Sandrine and Duplan, Isabelle and Piveteau, Catherine and Hennuyer, Nathalie and Staels, Bart and Deprez, Benoit and Deprez-Poulain, Rebecca

Identification of indole-based activators of insulin degrading enzyme

European Journal of Medicinal Chemistry (2022)

228, 113982

10.1016/J.EJMECH.2021.113982

Castellanos-Jankiewicz, Ashley and Guzmán-Quevedo, Omar and Fénelon, Valérie S. and Zizzari, Philippe and Quarta, Carmelo and Bellocchio, Luigi and Tailleux, Anne and Charton, Julie and Fernandois, Daniela and Henricsson, Marcus and Piveteau, Catherine and Simon, Vincent and Allard, Camille and Quemener, Sandrine and Guinot, Valentine and Hennuyer, Nathalie and Perino, Alessia and Duveau, Alexia and Maitre, Marlène and Leste-Lasserre, Thierry and Clark, Samantha and Dupuy, Nathalie and Cannich, Astrid and Gonzales, Delphine and Deprez, Benoit and Mithieux, Gilles and Dombrowicz, David and Bäckhed, Fredrik and Prevot, Vincent and Marsicano, Giovanni and Staels, Bart and Schoonjans, Kristina and Cota, Daniela

Hypothalamic bile acid-TGR5 signaling protects from obesity

Cell Metabolism (2021)

33, 1483-1492.e10

10.1016/J.CMET.2021.04.009

Hoguet, Vanessa and Lasalle, Manuel and Maingot, Mathieu and Dequirez, Geoffroy and Boulahjar, Rajaa and Leroux, Florence and Piveteau, Catherine and Herledan, Adrien and Biela, Alexandre and Dumont, Julie and Chávez-Talavera, Oscar and Belloy, Loïc and Duplan, Isabelle and Hennuyer, Nathalie and Butruille, Laura and Lestavel, Sophie and Sevin, Emmanuel and Culot, Maxime and Gosselet, Fabien and Staels, Bart and Deprez, Benoit and Tailleux, Anne and Charton, Julie

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor

Journal of Medicinal Chemistry (2021)

64, 1593-1610

10.1021/ACS.JMEDCHEM.0C01774

Medve, Laura and Gealageas, Ronan and Lam, Bao Vy and Guillaume, Valentin and Castillo-Aguilera, Omar and Camberlein, Virgyl and Piveteau, Catherine and Rosell, Melissa and Fleau, Charlotte and Warenghem, Sandrine and Charton, Julie and Dumont-Ryckembusch, Julie and Bosc, Damien and Leroux, Florence and van Endert, Peter and Deprez, Benoit and Deprez-Poulain, Rebecca

Modulators of hERAP2 discovered by high-throughput screening

European Journal of Medicinal Chemistry (2021)

211, 113053

10.1016/J.EJMECH.2020.113053

Faïon, Léo and Djaout, Kamel and Frita, Rosangela and Pintiala, Catalin and Cantrelle, Francois-Xavier and Moune, Martin and Vandeputte, Alexandre and Bourbiaux, Kevin and Piveteau, Catherine and Herledan, Adrien and Biela, Alexandre and Leroux, Florence and Kremer, Laurent and Blaise, Mickael and Tanina, Abdalkarim and Wintjens, René and Hanoulle, Xavier and Déprez, Benoit and Willand, Nicolas and Baulard, Alain R. and Flipo, Marion

Discovery of the first Mycobacterium tuberculosis MabA (FabG1) inhibitors through a fragment-based screening

European Journal of Medicinal Chemistry (2020)

200, 112440

10.1016/J.EJMECH.2020.112440

Lesire, Laetitia and Chaput, Ludovic and Cruz De Casas, Paulina and Rousseau, Fanny and Piveteau, Catherine and Dumont, Julie and Pointu, David and Déprez, Benoît and Leroux, Florence

High-Throughput Image-Based Aggresome Quantification

SLAS Discovery (2020)

25, 783-791

10.1177/2472555220919708

Villemagne, Baptiste and Machelart, Arnaud and Tran, Ngoc Chau and Flipo, Marion and Moune, Martin and Leroux, Florence and Piveteau, Catherine and Wohlkönig, Alexandre and Wintjens, René and Li, Xue and Gref, Ruxandra and Brodin, Priscille and Deprez, Benoit and Baulard, Alain R and Willand, Nicolas

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity

ACS Infectious Diseases (2020)

6, 366-378

10.1021/ACSINFECDIS.9B00277

Herledan, Adrien and Andres, Marine and Lejeune-Dodge, Aurore and Leroux, Florence and Biela, Alexandre and Piveteau, Catherine and Warenghem, Sandrine and Couturier, Cyril and Deprez, Benoit and Deprez-Poulain, Rebecca

Drug Target Engagement Using Coupled Cellular Thermal Shift Assay-Acoustic Reverse-Phase Protein Array

SLAS Discovery (2020)

25, 207-214

10.1177/2472555219897256

Costa-Gouveia, Joana and Pancani, Elisabetta and Jouny, Samuel and Machelart, Arnaud and Delorme, Vincent and Salzano, Giuseppina and Iantomasi, Raffaella and Piveteau, Catherine and Queval, Christophe J. and Song, Ok-Ryul and Flipo, Marion and Deprez, Benoit and Saint-André, Jean-Paul and Hureaux, José and Majlessi, Laleh and Willand, Nicolas and Baulard, Alain and Brodin, Priscille and Gref, Ruxandra

Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles

Scientific Reports (2018)

8,

10.1038/S41598-018-25177-2

Montaigne, David and Marechal, Xavier and Modine, Thomas and Coisne, Augustin and Mouton, Stéphanie and Fayad, Georges and Ninni, Sandro and Klein, Cédric and Ortmans, Staniel and Seunes, Claire and Potelle, Charlotte and Berthier, Alexandre and Gheeraert, Celine and Piveteau, Catherine and Deprez, Rebecca and Eeckhoute, Jérome and Duez, Hélène and Lacroix, Dominique and Deprez, Benoit and Jegou, Bruno and Koussa, Mohamed and Edme, Jean-Louis and Lefebvre, Philippe and Staels, Bart

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbalpha antagonism: a single-centre propensity-matched cohort study and a randomised study

The Lancet (2018)

391, 59-69

10.1016/S0140-6736(17)32132-3

Ahmed-Belkacem, Rostom and Hausdorff, Marcel and Delpal, Adrien and Sutto-Ortiz, Priscila and Colmant, Agathe M. G. and Touret, Franck and Ogando, Natacha S. and Snijder, Eric J. and Canard, Bruno and Coutard, Bruno and Vasseur, Jean-Jacques and Decroly, Etienne and Debart, Françoise

Potent Inhibition of SARS-CoV-2 nsp14 N7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

Journal of Medicinal Chemistry (2022)

65, 6231-6249

10.1021/ACS.JMEDCHEM.2C00120

Touret, Franck and Baronti, Cécile and Pastorino, Boris and Villarroel, Paola Mariela Saba and Ninove, Laetitia and Nougairède, Antoine and de Lamballerie, Xavier

In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5

Scientific Reports (2022)

12,

10.1038/S41598-022-16964-Z

Assmus, Frauke and Driouich, Jean-Sélim and Abdelnabi, Rana and Vangeel, Laura and Touret, Franck and Adehin, Ayorinde and Chotsiri, Palang and Cochin, Maxime and Foo, Caroline S. and Jochmans, Dirk and Kim, Seungtaek and Luciani, Léa and Moureau, Grégory and Park, Soonju and Pétit, Paul-Rémi and Shum, David and Wattanakul, Thanaporn and Weynand, Birgit and Fraisse, Laurent and Ioset, Jean-Robert and Mowbray, Charles E. and Owen, Andrew and Hoglund, Richard M. and Tarning, Joel and Lamballerie, Xavier de and Nougairède, Antoine and Neyts, Johan and Sjö, Peter and Escudié, Fanny and Scandale, Ivan and Chatelain, Eric

Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19

Microorganisms (2022)

10, 1639

10.3390/MICROORGANISMS10081639

Hernández, Sergio and Feracci, Mikael and De Jesus, Carolina Trajano and El Kazzi, Priscila and Kaci, Rafik and Garlatti, Laura and Mondielli, Clemence and Bailly, Fabrice and Cotelle, Philippe and Touret, Franck and de Lamballerie, Xavier and Coutard, Bruno and Decroly, Etienne and Canard, Bruno and Ferron, François and Alvarez, Karine

Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay

Antiviral Research (2022)

204, 105364

10.1016/J.ANTIVIRAL.2022.105364

Thébault, Stéphanie and Lejal, Nathalie and Dogliani, Alexis and Donchet, Amélie and Urvoas, Agathe and Valerio-Lepiniec, Marie and Lavie, Muriel and Baronti, Cécile and Touret, Franck and Da Costa, Bruno and Bourgon, Clara and Fraysse, Audrey and Saint-Albin-Deliot, Audrey and Morel, Jessica and Klonjkowski, Bernard and de Lamballerie, Xavier and Dubuisson, Jean and Roussel, Alain and Minard, Philippe and Le Poder, Sophie and Meunier, Nicolas and Delmas, Bernard

Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals

PLOS Pathogens (2022)

18, e1010799

10.1371/JOURNAL.PPAT.1010799

Goethals, Olivia and Kaptein, Suzanne J. F. and Kesteleyn, Bart and Bonfanti, Jean-François and Van Wesenbeeck, Liesbeth and Bardiot, Dorothée and Verschoor, Ernst J. and Verstrepen, Babs E. and Fagrouch, Zahra and Putnak, J. Robert and Kiemel, Dominik and Ackaert, Oliver and Straetemans, Roel and Lachau-Durand, Sophie and Geluykens, Peggy and Crabbe, Marjolein and Thys, Kim and Stoops, Bart and Lenz, Oliver and Tambuyzer, Lotke and De Meyer, Sandra and Dallmeier, Kai and McCracken, Michael K. and Gromowski, Gregory D. and Rutvisuttinunt, Wiriya and Jarman, Richard G. and Karasavvas, Nicos and Touret, Franck and Querat, Gilles and de Lamballerie, Xavier and Chatel-Chaix, Laurent and Milligan, Gregg N. and Beasley, David W. C. and Bourne, Nigel and Barrett, Alan D. T. and Marchand, Arnaud and Jonckers, Tim H. M. and Raboisson, Pierre and Simmen, Kenny and Chaltin, Patrick and Bartenschlager, Ralf and Bogers, Willy M. and Neyts, Johan and Van Loock, Marnix

Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates

Nature (2023)

615, 678-686

10.1038/S41586-023-05790-6

Touret, Franck and Giraud, Emilie and Bourret, Jérôme and Donati, Flora and Tran-Rajau, Jaouen and Chiaravalli, Jeanne and Lemoine, Frédéric and Agou, Fabrice and Simon-Lorière, Etienne and van der Werf, Sylvie and de Lamballerie, Xavier

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 omicron sub-lineages

iScience (2023)

26, 106413

10.1016/J.ISCI.2023.106413

Hausdorff, Marcel and Delpal, Adrien and Barelier, Sarah and Nicollet, Laura and Canard, Bruno and Touret, Franck and Colmant, Agathe and Coutard, Bruno and Vasseur, Jean-Jacques and Decroly, Etienne and Debart, Françoise

Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

European Journal of Medicinal Chemistry (2023)

256, 115474

10.1016/J.EJMECH.2023.115474

Driouich, Jean-Sélim and Bernadin, Ornéllie and Touret, Franck and de Lamballerie, Xavier and Nougairède, Antoine

Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model

Antiviral Research (2023)

215, 105638

10.1016/J.ANTIVIRAL.2023.105638

Li, Youzhi and Touret, Franck and de Lamballerie, Xavier and Nguyen, Michel and Laurent, Marion and Benoit-Vical, Françoise and Robert, Anne and Liu, Yan and Meunier, Bernard

Hybrid molecules based on an emodin scaffold. Synthesis and activity against SARS-CoV-2 and Plasmodium

Organic & Biomolecular Chemistry (2023)

21, 7382-7394

10.1039/D3OB01122D

Coutant, Frédéric and Touret, Franck and Pin, Jean-Jacques and Alonzo, Marina and Baronti, Cécile and Munier, Sandie and Attia, Mikaël and de Lamballerie, Xavier and Ferry, Tristan and Miossec, Pierre

Neutralizing and enhancing monoclonal antibodies in SARS-CoV-2 convalescent patients: lessons from early variant infection and impact on shaping emerging variants

Emerging Microbes & Infections (2024)

13,

10.1080/22221751.2024.2307510

Bouzidi, Hawa Sophia and Driouich, Jean-Sélim and Klitting, Raphaëlle and Bernadin, Ornéllie and Piorkowski, Géraldine and Amaral, Rayane and Fraisse, Laurent and Mowbray, Charles E. and Scandale, Ivan and Escudié, Fanny and Chatelain, Eric and de Lamballerie, Xavier and Nougairède, Antoine and Touret, Franck

Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains

Antiviral Research (2024)

222, 105814

10.1016/J.ANTIVIRAL.2024.105814

Petit, Paul-Rémi and Touret, Franck and Driouich, Jean-Sélim and Cochin, Maxime and Luciani, Léa and Bernadin, Ornéllie and Laprie, Caroline and Piorkowski, Géraldine and Fraisse, Laurent and Sjö, Peter and Mowbray, Charles E. and Escudié, Fanny and Scandale, Ivan and Chatelain, Eric and de Lamballerie, Xavier and Solas, Caroline and Nougairède, Antoine

Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns

Heliyon (2024)

10, e30862

10.1016/J.HELIYON.2024.E30862

Luciani, Léa and Combe, Pierre and Touret, Franck and Gazin, Céline and Klitting, Raphaëlle and Pezzi, Laura and Thirion, Laurence and Charrel, Rémi and Grard, Gilda and de Lamballerie, Xavier and Nougairède, Antoine

Broad-spectrum dengue virus detection using the commercial RealStar dengue RT-PCR kit 3.0 (Altona) and an in-house combined real-time RT-PCR assay

Heliyon (2024)

10, e31252

10.1016/J.HELIYON.2024.E31252

Driouich, Jean-Sélim and Cochin, Maxime and Lingas, Guillaume and Luciani, Léa and Baronti, Cécile and Bernadin, Ornéllie and Gilles, Magali and Villarroel, Paola Mariela Saba and Moureau, Grégory and Petit, Paul-Rémi and Dupont, Axelle and Izopet, Jacques and Kamar, Nassim and Autran, Brigitte and Paintaud, Gilles and Caillard, Sophie and le Bourgeois, Amandine and Richez, Christophe and Couzi, Lionel and Xhaard, Aliénor and Marjanovic, Zora and Avouac, Jerome and Jacquet, Caroline and Anglicheau, Dany and Cheminant, Morgane and Nguyen, Stéphanie and Terrier, Benjamin and Gottenberg, Jacques Eric and Besson, Caroline and Letrou, Sophie and Tine, Josephine and Basilua, Joe Miantezila and Angoulvant, Denis and Tardivon, Coralie and Blancho, Gilles and Martin-Blondel, Guillaume and Yazdanpanah, Yazdan and Mentré, France and Lévy, Vincent and Touret, Franck and Guedj, Jérémie and de Lamballerie, Xavier and Nougairède, Antoine

Preclinical in vivo assessment of the activity of AZD7442 anti-SARS-CoV-2 monoclonal antibodies against Omicron sublineages

Biomedicine & Pharmacotherapy (2024)

177, 116988

10.1016/J.BIOPHA.2024.116988

Roux, Hugo and Touret, Franck and Coluccia, Antonio and Khoumeri, Omar and Di Giorgio, Carole and Majdi, Chaimae and Sciò, Pietro and Silvestri, Romano and Vanelle, Patrice and Roche, Manon

New potent EV-A71 antivirals targeting capsid

European Journal of Medicinal Chemistry (2024)

276, 116658

10.1016/J.EJMECH.2024.116658

Bouzidi, Hawa Sophia and Sen, Selin and Piorkowski, Géraldine and Pezzi, Laura and Ayhan, Nazli and Fontaine, Albin and Canivez, Thomas and Geulen, Manon and Amaral, Rayane and Grard, Gilda and Durand, Guillaume André and de Lamballerie, Xavier and Touret, Franck and Klitting, Raphaëlle

Genomic surveillance reveals a dengue 2 virus epidemic lineage with a marked decrease in sensitivity to Mosnodenvir

Nature Communications (2024)

15,

10.1038/S41467-024-52819-Z

Sama, Bhawna and Selisko, Barbara and Falcou, Camille and Fattorini, Véronique and Piorkowski, Géraldine and Touret, Franck and Donckers, Kim and Neyts, Johan and Jochmans, Dirk and Shannon, Ashleigh and Coutard, Bruno and Canard, Bruno

The effects of Remdesivir's functional groups on its antiviral potency and resistance against the SARS-CoV-2 polymerase

Antiviral Research (2024)

232, 106034

10.1016/J.ANTIVIRAL.2024.106034

Roux, Hugo and Touret, Franck and Coluccia, Antonio and Scio, Pietro and Bouzidi, Hawa Sophia and di Giorgio, Carole and Gattacceca, Florence and Khoumeri, Omar and Silvestri, Romano and Vanelle, Patrice and Roche, Manon

Design and synthesis of novel thioether analogs as promising antiviral agents: In vitro activity against enteroviruses of interest

European Journal of Medicinal Chemistry (2025)

288, 117395

10.1016/J.EJMECH.2025.117395

Gourjault, Cyrille and Pezzi, Laura and Doudier, Barbara and Minodier, Philippe and Klitting, Raphaëlle and Cano, Philippe and Ayhan, Nazli and Touret, Franck and Grard, Gilda and Durand, Guillaume A and Driouich, Jean-Sélim and Luciani, Léa and Nougairède, Antoine and Lagier, Jean-Christophe and de Lamballerie, Xavier and Cassir, Nadim

Persistence of Oropouche virus in body fluids among imported cases in France, 2024

The Lancet Infectious Diseases (2025)

25, e64-e65

10.1016/S1473-3099(24)00815-6

Darmuzey, Maïlis and Touret, Franck and Slowikowski, Emily and Gladwyn-Ng, Ivan and Ahuja, Karan and Sanchez-Felipe, Lorena and de Lamballerie, Xavier and Verfaillie, Catherine and Marques, Pedro E. and Neyts, Johan and Kaptein, Suzanne J. F.

Epidemic Zika virus strains from the Asian lineage induce an attenuated fetal brain pathogenicity

Nature Communications (2024)

15,

10.1038/S41467-024-55155-4

Hérate, Cécile and Marlin, Romain and Touret, Franck and Dereuddre-Bosquet, Nathalie and Donati, Flora and Relouzat, Francis and Junges, Laura and Galhaut, Mathilde and Dehan, Océane and Sconosciuti, Quentin and Nougairède, Antoine and de Lamballerie, Xavier and van der Werf, Sylvie and Le Grand, Roger

Sotrovimab retains activity against SARS-CoV-2 omicron variant BQ.1.1 in a non-human primate model

Heliyon (2023)

9, e16664

10.1016/J.HELIYON.2023.E16664

Gallian, Pierre and Brisbarre, Nadége and Nurtop, Elif and Le Cam, Sophie and Franck, Touret and Isnard, Christine and Malard, Lucile and Laperche, Syria and Richard, Pascale and Morel, Pascal and Tiberghien, Pierre and de Lamballerie, Xavier

Low neutralization capacity against SARS-CoV-2 Omicron BQ.1.1 of convalescent plasma collected during circulation of Omicron BA.1

Vox Sanguinis (2023)

118, 407-408

10.1111/VOX.13418

Touret, Franck and Martin-Blondel, Guillaume and de Lamballerie, Xavier and Dupont, Axelle and Izopet, Jacques and Mentré, France and Kamar, Nassim and Autran, Brigitte and Paintaud, Gilles and Caillard, Sophie and Richez, Christophe and Couzi, Lionel and Xhaard, Aliénor and Marjanovic, Zora and Avouac, Jerome and Jacquet, Caroline and Anglicheau, Dany and Cheminant, Morgane and Yazdanpanah, Yazdan and N'Guyen, Stéphanie and Terrier, Benjamin and Gottenberg, Jacques Eric and Besson, Caroline and Letrou, Sophie and Kali, Sabrina and Angoulvant, Denis and Barthélémy, Karine and Priet, Stéphane and Nurtop, Elif and Sanchez, Ventzislava Petrov and Tardivon, Coralie and Blancho, Gilles and Le Bourgeois, Amandine and Lévy, Vincent

Low to undetectable Omicron BQ.1.1 neutralization by patient's sera a month after initiation of AZD7442 600 mg

Journal of Infection (2023)

86, e126-e129

10.1016/J.JINF.2023.02.002

Politi, Maria D. and Gallo, Angelo and Bouras, Georgios and Birkou, Maria and Canard, Bruno and Coutard, Bruno and Spyroulias, Georgios A.

1H, 13C, 15N backbone resonance assignment of apo and ADP-ribose bound forms of the macro domain of Hepatitis E virus through solution NMR spectroscopy

Biomolecular NMR Assignments (2023)

17, 1-8

10.1007/S12104-022-10111-5

Hurdiss, Daniel L. and El Kazzi, Priscila and Bauer, Lisa and Papageorgiou, Nicolas and Ferron, François P. and Donselaar, Tim and van Vliet, Arno L.W. and Shamorkina, Tatiana M. and Snijder, Joost and Canard, Bruno and Decroly, Etienne and Brancale, Andrea and Zeev-Ben-Mordehai, Tzviya and Förster, Friedrich and van Kuppeveld, Frank J.M. and Coutard, Bruno

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Science Advances (2022)

8,

10.1126/SCIADV.ABJ7615

Ortega Granda, Oney and Valle, Coralie and Shannon, Ashleigh and Decroly, Etienne and Canard, Bruno and Coutard, Bruno and Rabah, Nadia

Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5' End

Journal of Virology (2021)

95,

10.1128/JVI.00777-21

Thorel, Lucie and Elie, Nicolas and Morice, Pierre-Marie and Weiswald, Louis-Bastien and Florent, Romane and Perréard, Marion and Giffard, Florence and Ricou, Agathe and Leman, Raphaël and Babin, Guillaume and Lebrun, Jean-François and Martin, Sandrine and Briand, Mélanie and Lambert, Bernard and Joly, Florence and Blanc-Fournier, Cécile and Vaur, Dominique and Dolivet, Enora and Plancoulaine, Benoit and Poulain, Laurent

Automated Scoring to Assess RAD51-Mediated Homologous Recombination in Ovarian Patient-Derived Tumor Organoids

Laboratory Investigation (2025)

105, 104097

10.1016/J.LABINV.2025.104097

Gall, Gwenn Le and Cherifi, François and Divoux, Jordane and Florent, Romane and Christy, François and Leconte, Alexandra and San, Chankannira and Devillers, Amélie and Desmartin, Guillaume and Lecouflet, Lucie and Clarisse, Bénédicte and Ballesta, Samantha and Thorel, Lucie and Dubois, Brice and Harter, Valentin and Rousseau, Nathalie and Gaichies, Léopold and Martin-Françoise, Sandrine and Le Brun, Jean-François and Dolivet, Enora and Rouzier, Roman and Jeanne, Corinne and Blanc-Fournier, Cécile and Figeac, Martin and Leman, Raphaël and Castera, Laurent and Poulain, Laurent and Weiswald, Louis-Bastien and Joly, Florence

The PENDOR study: establishment of a panel of patient-derived tumor organoids from endometrial cancer to assess efficacy of PARP inhibitors

BMC Cancer (2025)

25,

10.1186/S12885-025-13590-6

Thorel, Lucie and Perréard, Marion and Florent, Romane and Divoux, Jordane and Coffy, Sophia and Vincent, Audrey and Gaggioli, Cédric and Guasch, Géraldine and Gidrol, Xavier and Weiswald, Louis-Bastien and Poulain, Laurent

Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology

Experimental & Molecular Medicine (2024)

56, 1531-1551

10.1038/S12276-024-01272-5

Thorel, Lucie and Divoux, Jordane and Lequesne, Justine and Babin, Guillaume and Morice, Pierre-Marie and Florent, Romane and Desmartin, Guillaume and Lecouflet, Lucie and Marde Alagama, Chloé and Leconte, Alexandra and Clarisse, Bénédicte and Briand, Mélanie and Rouzier, Roman and Gaichies, Léopold and Martin-Françoise, Sandrine and Le Brun, Jean-François and Denoyelle, Christophe and Vigneron, Nicolas and Jeanne, Corinne and Blanc-Fournier, Cécile and Leman, Raphaël and Vaur, Dominique and Figeac, Martin and Meryet-Figuiere, Matthieu and Joly, Florence and Weiswald, Louis-Bastien and Poulain, Laurent and Dolivet, Enora

The OVAREX study: Establishment of ex vivo ovarian cancer models to validate innovative therapies and to identify predictive biomarkers

BMC Cancer (2024)

24,

10.1186/S12885-024-12429-W

Thorel, Lucie and Morice, Pierre-Marie and Paysant, Hippolyte and Florent, Romane and Babin, Guillaume and Thomine, Cécilia and Perréard, Marion and Abeilard, Edwige and Giffard, Florence and Brotin, Emilie and Denoyelle, Christophe and Villenet, Céline and Sebda, Shéhérazade and Briand, Mélanie and Joly, Florence and Dolivet, Enora and Goux, Didier and Blanc-Fournier, Cécile and Jeanne, Corinne and Villedieu, Marie and Meryet-Figuiere, Matthieu and Figeac, Martin and Poulain, Laurent and Weiswald, Louis-Bastien

Comparative analysis of response to treatments and molecular features of tumor-derived organoids versus cell lines and PDX derived from the same ovarian clear cell carcinoma

Journal of Experimental & Clinical Cancer Research (2023)

42,

10.1186/S13046-023-02809-8

Divoux, Jordane and Florent, Romane and Jacobs, Margaux and Lequesne, Justine and Grellard, Jean-Michel and San, Chankannira and Grossi, Sara and Kerdja, Katia and Clarisse, Bénédicte and Boudier, Gwenaelle and Cherifi, François and Briand, Mélanie and Dolivet, Enora and Johnson, Alisson and Dubois, Brice and Harter, Valentin and Lacroix, Joëlle and Raboutet, Charlotte and Marie, Brigitte and Rousseau, Nathalie and Blanc-Fournier, Cécile and Vaur, Dominique and Figeac, Martin and Poulain, Laurent and Weiswald, Louis-Bastien and Emile, George

The TRIPLEX study: use of patient-derived tumor organoids as an innovative tool for precision medicine in triple-negative breast cancer

BMC Cancer (2023)

23,

10.1186/S12885-023-11362-8

Perréard, Marion and Florent, Romane and Divoux, Jordane and Grellard, Jean-Michel and Lequesne, Justine and Briand, Mélanie and Clarisse, Bénédicte and Rousseau, Nathalie and Lebreton, Esther and Dubois, Brice and Harter, Valentin and Lasne-Cardon, Audrey and Drouet, Julien and Johnson, Alisson and Le Page, Anne-Laure and Bazille, Céline and Jeanne, Corinne and Figeac, Martin and Goardon, Nicolas and Vaur, Dominique and Micault, Emmanuel and Humbert, Maxime and Thariat, Juliette and Babin, Emmanuel and Poulain, Laurent and Weiswald, Louis-Bastien and Bastit, Vianney

ORGAVADS: establishment of tumor organoids from head and neck squamous cell carcinoma to assess their response to innovative therapies

BMC Cancer (2023)

23,

10.1186/S12885-023-10692-X

Dos Santos, Mélanie and Lequesne, Justine and Leconte, Alexandra and Corbinais, Stéphane and Parzy, Aurélie and Guilloit, Jean-Marc and Varatharajah, Sharmini and Brachet, Pierre-Emmanuel and Dorbeau, Marine and Vaur, Dominique and Weiswald, Louis-Bastien and Poulain, Laurent and Le Gallic, Corentin and Castera-Tellier, Marie and Galais, Marie-Pierre and Clarisse, Bénédicte

Perioperative treatment in resectable gastric cancer with spartalizumab in combination with fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT): a phase II study (GASPAR)

BMC Cancer (2022)

22,

10.1186/S12885-022-09623-Z

Hadj Bachir, Elsa and Poiraud, Charles and Paget, Sonia and Stoup, Nicolas and El Moghrabi, Soumaya and Duchêne, Belinda and Jouy, Nathalie and Bongiovanni, Antonino and Tardivel, Meryem and Weiswald, Louis-Bastien and Vandepeutte, Marie and Beugniez, César and Escande, Fabienne and Leteurtre, Emmanuelle and Poulain, Laurent and Lagadec, Chann and Pigny, Pascal and Jonckheere, Nicolas and Renaud, Florence and Truant, Stephanie and Van Seuningen, Isabelle and Vincent, Audrey

A new pancreatic adenocarcinoma-derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms

Biology of the Cell (2022)

114, 32-55

10.1111/BOC.202100003

Perréard, Marion and Florent, Romane and Thorel, Lucie and Vincent, Audrey and Weiswald, Louis-Bastien and Poulain, Laurent

Les organoïdes dérivés de tumeurs (ou tumoroïdes), des outils de choix pour la médecine de précision en oncologie

médecine/sciences (2022)

38, 888-895

10.1051/MEDSCI/2022149

Thorel, Lucie and Florent, Romane and Perréard, Marion and Vincent, Audrey and Poulain, Laurent and Weiswald, Louis-Bastien

Les tumoroïdes, modèles précliniques en plein essor pour l'oncologie

médecine/sciences (2022)

38, 880-887

10.1051/MEDSCI/2022148

Wambecke, Anaïs and Ahmad, Mohammad and Morice, Pierre-Marie and Lambert, Bernard and Weiswald, Louis-Bastien and Vernon, Mégane and Vigneron, Nicolas and Abeilard, Edwige and Brotin, Emilie and Figeac, Martin and Gauduchon, Pascal and Poulain, Laurent and Denoyelle, Christophe and Meryet-Figuiere, Matthieu

The lncRNA `UCA1' modulates the response to chemotherapy of ovarian cancer through direct binding to miR-27a-5p and control of UBE2N levels

Molecular Oncology (2021)

15, 3659-3678

10.1002/1878-0261.13045

Morice, Pierre-Marie and Coquan, Elodie and Weiswald, Louis-Bastien and Lambert, Bernard and Vaur, Dominique and Poulain, Laurent

Identifying patients eligible for PARP inhibitor treatment: from NGS-based tests to 3D functional assays

British Journal of Cancer (2021)

125, 7-14

10.1038/S41416-021-01295-Z

Florent, Romane and Weiswald, Louis-Bastien and Lambert, Bernard and Brotin, Emilie and Abeilard, Edwige and Louis, Marie-Hélène and Babin, Guillaume and Poulain, Laurent and N'Diaye, Monique

Bim, Puma and Noxa upregulation by Naftopidil sensitizes ovarian cancer to the BH3-mimetic ABT-737 and the MEK inhibitor Trametinib

Cell Death & Disease (2020)

11,

10.1038/S41419-020-2588-8

Vernon, Mégane and Lambert, Bernard and Meryet-Figuière, Matthieu and Brotin, Emilie and Weiswald, Louis-Bastien and Paysant, Hippolyte and Vigneron, Nicolas and Wambecke, Anaïs and Abeilard, Edwige and Giffard, Florence and Louis, Marie-Hélène and Blanc-Fournier, Cécile and Gauduchon, Pascal and Poulain, Laurent and Denoyelle, Christophe

Functional miRNA Screening Identifies Wide-ranging Antitumor Properties of miR-3622b-5p and Reveals a New Therapeutic Combination Strategy in Ovarian Tumor Organoids

Molecular Cancer Therapeutics (2020)

19, 1506-1519

10.1158/1535-7163.MCT-19-0510

Benhabiles, Hana and Gonzalez-Hilarion, Sara and Amand, Séverine and Bailly, Christine and Prévotat, Anne and Reix, Philippe and Hubert, Dominique and Adriaenssens, Eric and Rebuffat, Sylvie and Tulasne, David and Lejeune, Fabrice

Optimized approach for the identification of highly efficient correctors of nonsense mutations in human diseases

PLOS ONE (2017)

12, e0187930

10.1371/JOURNAL.PONE.0187930

Trzaska, Carole and Amand, Séverine and Bailly, Christine and Leroy, Catherine and Marchand, Virginie and Duvernois-Berthet, Evelyne and Saliou, Jean-Michel and Benhabiles, Hana and Werkmeister, Elisabeth and Chassat, Thierry and Guilbert, Romain and Hannebique, David and Mouray, Anthony and Copin, Marie-Christine and Moreau, Pierre-Arthur and Adriaenssens, Eric and Kulozik, Andreas and Westhof, Eric and Tulasne, David and Motorin, Yuri and Rebuffat, Sylvie and Lejeune, Fabrice

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Nature Communications (2020)

11,

10.1038/S41467-020-15140-Z

Andrade, Milene Aparecida and Mottin, Melina and Sousa, Bruna K.de P. and Barbosa, João Alexandre Ribeiro Gonçalves and dos Santos Azevedo, Clênia and Lasse Silva, Camila and Gonçalves de Andrade, Marina and Motta, Flávia Nader and Maulay-Bailly, Christine and Amand, Séverine and Santana, Jaime Martins de and Horta Andrade, Carolina and Grellier, Philippe and Bastos, Izabela M.D.

Identification of novel Zika virus NS3 protease inhibitors with different inhibition modes by integrative experimental and computational approaches

Biochimie (2023)

212, 143-152

10.1016/J.BIOCHI.2023.04.004

Schelle, Baptiste and Fargier, Jules and Grisel, Clément and Askenatzis, Laurie and Gallard, Jean-François and Desrat, Sandy and Bignon, Jérome and Roussi, Fanny and Norsikian, Stéphanie

Fast and effective preparation of highly cytotoxic hybrid molecules of schweinfurthin E and OSW-1

Organic & Biomolecular Chemistry (2025)

23, 2380-2385

10.1039/D5OB00059A

Jézéquel, Gwenaëlle and Grimanelli, Zoé and Guimard, Carole and Bigay, Joëlle and Haddad, Juliano and Bignon, Jérôme and Apel, Cécile and Steinmetz, Vincent and Askenatzis, Laurie and Levaïque, Hélène and Pradelli, Clara and Pham, Van Cuong and Huong, Doan T. M. and Litaudon, Marc and Gautier, Romain and El Kalamouni, Chaker and Antonny, Bruno and Desrat, Sandy and Mesmin, Bruno and Roussi, Fanny

Minimalist Natural ORPphilin Macarangin B Delineates OSBP Biological Function

Journal of Medicinal Chemistry (2025)

68, 196-211

10.1021/ACS.JMEDCHEM.4C01705

Zhang, Kena and Tran, Christine and Yan, Jun and Rodríguez Caro, Juan Francisco and Bignon, Jérôme and Alami, Mouad and Lamaa, Diana and Brachet, Etienne and Hamze, Abdallah

1,1'-Diarylethylene as a Key Additive for the Visible Light Synthesis of Bioactive Dihydrobenzo[a]phenanthridine Compounds

The Journal of Organic Chemistry (2024)

89, 15117-15136

10.1021/ACS.JOC.4C01891

El Abbouchi, Abdelmoula and Mkhayar, Khaoula and Elkhattabi, Souad and El Brahmi, Nabil and Hiebel, Marie-Aude and Bignon, Jérôme and Guillaumet, Gérald and Suzenet, Franck and El Kazzouli, Saïd

Design, Synthesis, Computational Studies, and Anti-Proliferative Evaluation of Novel Ethacrynic Acid Derivatives Containing Nitrogen Heterocycle, Urea, and Thiourea Moieties as Anticancer Agents

Molecules (2024)

29, 1437

10.3390/MOLECULES29071437

Lamaa, Diana and Cailleau, Catherine and Vergnaud, Juliette and Mougin, Julie and Bignon, Jérôme and Alami, Mouad and Fattal, Elias and Hamze, Abdallah and Tsapis, Nicolas

Overcoming Solubility Challenges: Liposomal isoCoQ-Carbazole as a Promising Anti-Tumor Agent for Inoperable and Radiation-Insensitive cancers

ChemBioChem (2024)

25,

10.1002/CBIC.202400062

Le Loarer, Alexandre and Dufossé, Laurent and Bignon, Jérôme and Frédérich, Michel and Ledoux, Allison and Fouillaud, Mireille and Gauvin-Bialecki, Anne

OSMAC Method to Assess Impact of Culture Parameters on Metabolomic Diversity and Biological Activity of Marine-Derived Actinobacteria

Marine Drugs (2023)

22, 23

10.3390/MD22010023

Michel, Laurane and Auvray, Marie and Askenatzis, Laurie and Badet-Denisot, Marie-Ange and Bignon, Jérôme and Durand, Philippe and Mahuteau-Betzer, Florence and Chevalier, Arnaud

Visualization of an Endogenous Mitochondrial Azoreductase Activity under Normoxic Conditions Using a Naphthalimide Azo-Based Fluorogenic Probe

Analytical Chemistry (2024)

96, 1774-1780

10.1021/ACS.ANALCHEM.3C05030

Barrault, Maxime and Leclair, Elise and Kumeko, Etornam Kofi and Jacquet, Eric and Bouloc, Philippe

Staphylococcal sRNA IsrR downregulates methylthiotransferase MiaB under iron-deficient conditions

Microbiology Spectrum (2024)

12,

10.1128/SPECTRUM.03888-23

Barrault, Maxime and Chabelskaya, Svetlana and Coronel-Tellez, Rodrigo H and Toffano-Nioche, Claire and Jacquet, Eric and Bouloc, Philippe

Staphylococcal aconitase expression during iron deficiency is controlled by an sRNA-driven feedforward loop and moonlighting activity

Nucleic Acids Research (2024)

52, 8241-8253

10.1093/NAR/GKAE506

Alvaro-Aranda, Lucia and Petitalot, Ambre and Djeghmoum, Yasmina and Panigada, Davide and Singh, Jenny Kaur and Ehlén, Åsa and Vugic, Domagoj and Martin, Charlotte and Miron, Simona and Contreras-Perez, Aida and Nhiri, Naima and Boucherit, Virginie and Lafitte, Philippe and Dumoulin, Isaac and Quiles, Francisco and Rouleau, Etienne and Jacquet, Eric and Feliubadaló, Lidia and del Valle, Jesús and Sharan, Shyam K and Stoppa-Lyonnet, Dominique and Zinn-Justin, Sophie and Lázaro, Conxi and Caputo, Sandrine M and Carreira, Aura

The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination

Nucleic Acids Research (2024)

52, 6964-6976

10.1093/NAR/GKAD1222

Auzat, Isabelle and Ouldali, Malika and Jacquet, Eric and Fauler, Beatrix and Mielke, Thorsten and Tavares, Paulo

Dual function of a highly conserved bacteriophage tail completion protein essential for bacteriophage infectivity

Communications Biology (2024)

7,

10.1038/S42003-024-06221-6

Lim, Wan Ching and Marques Da Costa, Maria Eugenia and Godefroy, Karine and Jacquet, Eric and Gragert, Loren and Rondof, Windy and Marchais, Antonin and Nhiri, Naima and Dalfovo, Davide and Viard, Mathias and Labaied, Nizar and Khan, Asif M. and Dessen, Philippe and Romanel, Alessandro and Pasqualini, Claudia and Schleiermacher, Gudrun and Carrington, Mary and Zitvogel, Laurence and Scoazec, Jean-Yves and Geoerger, Birgit and Salmon, Jerome

Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid cancers

Frontiers in Immunology (2024)

14,

10.3389/FIMMU.2023.1265469

Jézéquel, Gwenaëlle and Rampal, Céline and Guimard, Carole and Kovacs, David and Polidori, Joël and Bigay, Joëlle and Bignon, Jérôme and Askenatzis, Laurie and Litaudon, Marc and Pham, Van-Cuong and Huong, Doan T. M. and Nguyen, Anvi Laetitia and Pruvost, Alain and Virolle, Thierry and Mesmin, Bruno and Desrat, Sandy and Antonny, Bruno and Roussi, Fanny

Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein

Journal of Medicinal Chemistry (2023)

66, 14208-14220

10.1021/ACS.JMEDCHEM.3C01298

Alami, Omar and Laurent, Régis and Tassé, Marine and Coppel, Yannick and Bignon, Jérôme and El Kazzouli, Saïd and Majoral, Jean-Pierre and El Brahmi, Nabil and Caminade, Anne-Marie

"Click" Chemistry for the Functionalization of Graphene Oxide with Phosphorus Dendrons: Synthesis, Characterization and Preliminary Biological Properties

Chemistry - A European Journal (2023)

29,

10.1002/CHEM.202302198

Losa, Romain and Lorton, Charlotte and Retailleau, Pascal and Bignon, Jérôme and Voituriez, Arnaud

Fluorinated 2-Azetines: Synthesis, Applications, Biological Tests, and Development of a Catalytic Process

Organic Letters (2023)

25, 5140-5144

10.1021/ACS.ORGLETT.3C01888

Jia, Tao and Diane, Oumar and Ghosh, Deepanjan and Skander, Myriem and Fontaine, Gaelle and Retailleau, Pascal and Poupon, Joël and Bignon, Jérôme and Moulai Siasia, Ytabelle Maga and Servajean, Vincent and Hue, Nathalie and Betzer, Jean-François and Marinetti, Angela and Bombard, Sophie

Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (N-Heterocyclic Carbene)-Amine-Pt(II) Complexes

Journal of Medicinal Chemistry (2023)

66, 6836-6848

10.1021/ACS.JMEDCHEM.3C00267

Le Loarer, Alexandre and Marcellin-Gros, Rémy and Dufossé, Laurent and Bignon, Jérôme and Frédérich, Michel and Ledoux, Allison and Queiroz, Emerson Ferreira and Wolfender, Jean-Luc and Gauvin-Bialecki, Anne and Fouillaud, Mireille

Prioritization of Microorganisms Isolated from the Indian Ocean Sponge Scopalina hapalia Based on Metabolomic Diversity and Biological Activity for the Discovery of Natural Products

Microorganisms (2023)

11, 697

10.3390/MICROORGANISMS11030697

El Abbouchi, Abdelmoula and El Brahmi, Nabil and Hiebel, Marie-Aude and Ghammaz, Hamza and El Fahime, Elmostafa and Bignon, Jérôme and Guillaumet, Gérald and Suzenet, Franck and El Kazzouli, Saïd

Improvement of the Chemical Reactivity of Michael Acceptor of Ethacrynic Acid Correlates with Antiproliferative Activities

Molecules (2023)

28, 910

10.3390/MOLECULES28020910

Grammatika Pavlidou, Nefeli and Dobrev, Shokoufeh and Beneke, Kira and Reinhardt, Franziska and Pecha, Simon and Jacquet, Eric and Abu-Taha, Issam H and Schmidt, Constanze and Voigt, Niels and Kamler, Markus and Schnabel, Renate B and Baczkó, Istvan and Garnier, Anne and Reichenspurner, Hermann and Nikolaev, Viacheslav O and Dobrev, Dobromir and Molina, Cristina E

Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism

European Heart Journal (2023)

44, 2483-2494

10.1093/EURHEARTJ/EHAD086

Sartre, Candice and Peurois, François and Ley, Marie and Kryszke, Marie-Hélène and Zhang, Wenhua and Courilleau, Delphine and Fischmeister, Rodolphe and Ambroise, Yves and Zeghouf, Mahel and Cianferani, Sarah and Ferrandez, Yann and Cherfils, Jacqueline

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Nature Communications (2023)

14,

10.1038/S41467-023-39894-4

Dzul Keflee, Rashidi and Leong, Kok Hoong and Ogawa, Satoshi and Bignon, Jerome and Chan, Mun Chiang and Kong, Kin Weng

Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer

Biochemical Pharmacology (2022)

205, 115262

10.1016/J.BCP.2022.115262

Hauguel, Camille and Ducellier, Sarah and Provot, Olivier and Ibrahim, Nada and Lamaa, Diana and Balcerowiak, Coline and Letribot, Boris and Nascimento, Megane and Blanchard, Vincent and Askenatzis, Laurie and Levaique, Helene and Bignon, Jérôme and Baschieri, Francesco and Bauvais, Cyril and Bollot, Guillaume and Renko, Dolor and Deroussent, Alain and Prost, Bastien and Laisne, Marie-Catherine and Michallet, Sophie and Lafanechère, Laurence and Papot, Sébastien and Montagnac, Guillaume and Tran, Christine and Alami, Mouad and Apcher, Sebastien and Hamze, Abdallah

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors

European Journal of Medicinal Chemistry (2022)

240, 114573

10.1016/J.EJMECH.2022.114573

Le Boulch, Marine and Jacquet, Eric and Nhiri, Naïma and Shmulevitz, Maya and Jaïs, Philippe H.

Rational design of an artificial tethered enzyme for non-templated post-transcriptional mRNA polyadenylation by the second generation of the C3P3 system

Scientific Reports (2024)

14,

10.1038/S41598-024-55947-0

Liu, Dawei and Peyre, Félix and Loissell-Baltazar, Yahir Alberto and Courilleau, Delphine and Lacas-Gervais, Sandra and Nicolas, Valérie and Jacquet, Eric and Dokudovskaya, Svetlana and Taran, Frédéric and Cintrat, Jean-Christophe and Brenner, Catherine

Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming

Cells (2022)

11, 474

10.3390/CELLS11030474

Malard, Florian and Jacquet, Eric and Nhiri, Naima and Sizun, Christina and Chabrier, Amélie and Messaoudi, Samir and Dejeu, Jérôme and Betzi, Stéphane and Zhang, Xu and Thureau, Aurélien and Lescop, Ewen

Revisiting the Molecular Interactions between the Tumor Protein TCTP and the Drugs Sertraline/Thioridazine

ChemMedChem (2022)

17,

10.1002/CMDC.202100528

Grimbert, Lucile and Sanz, Maria-Nieves and Gressette, Mélanie and Rucker-Martin, Catherine and Novotova, Marta and Solgadi, Audrey and Karoui, Ahmed and Gomez, Susana and Bedouet, Kaveen and Jacquet, Eric and Lemaire, Christophe and Veksler, Vladimir and Mericskay, Mathias and Ventura-Clapier, Renée and Piquereau, Jérôme and Garnier, Anne

Spatiotemporal AMPKalpha2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Biology of Sex Differences (2021)

12,

10.1186/S13293-021-00394-Z

Liu, Dawei and Peyre, Félix and Loissell-Baltazar, Yahir Alberto and Courilleau, Delphine and Lacas-Gervais, Sandra and Nicolas, Valérie and Jacquet, Eric and Dokudovskaya, Svetlana and Taran, Frédéric and Cintrat, Jean-Christophe and Brenner, Catherine

Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming

Cells (2022)

11, 474

10.3390/CELLS11030474

Hoang, Minh-Duc and Bodin, Jean-Baptiste and Savina, Farah and Steinmetz, Vincent and Bignon, Jérôme and Durand, Philippe and Clavier, Gilles and Méallet-Renault, Rachel and Chevalier, Arnaud

"CinNapht" dyes: a new cinnoline/naphthalimide fused hybrid fluorophore. Synthesis, photo-physical study and use for bio-imaging

RSC Advances (2021)

11, 30088-30092

10.1039/D1RA05110E

Paysant, Hippolyte and Hedir, Siham and Justaud, Frédéric and Weiswald, Louis Bastien and El Dine, Assaad Nasr and Soulieman, Ali and Hachem, Ali and Elie, Nicolas and Brotin, Emilie and Denoyelle, Christophe and Bignon, Jérôme and Roussi, Fanny and Jouanne, Marie and Tasseau, Olivier and Roisnel, Thierry and Voisin-Chiret, Anne Sophie and Grée, René and Levoin, Nicolas and Poulain, Laurent

Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

Organic & Biomolecular Chemistry (2021)

19, 8968-8987

10.1039/D1OB01521D

El Abbouchi, Abdelmoula and El Brahmi, Nabil and Hiebel, Marie-Aude and Bignon, Jérôme and Guillaumet, Gérald and Suzenet, Franck and El Kazzouli, Saïd

Synthesis and evaluation of a novel class of ethacrynic acid derivatives containing triazoles as potent anticancer agents

Bioorganic Chemistry (2021)

115, 105293

10.1016/J.BIOORG.2021.105293

Mignani, Serge and Bignon, Jérôme and Shi, Xiangyang and Majoral, Jean-Pierre

First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

Molecules (2021)

26, 3708

10.3390/MOLECULES26123708

Pecnard, Shannon and Hamze, Abdallah and Bignon, Jérome and Prost, Bastien and Deroussent, Alain and Gallego-Yerga, Laura and Peláez, Rafael and Paik, Ji Yeon and Diederich, Marc and Alami, Mouad and Provot, Olivier

Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues

European Journal of Medicinal Chemistry (2021)

223, 113656

10.1016/J.EJMECH.2021.113656

Daressy, Florian and Malard, Florian and Seguy, Line and Guérineau, Vincent and Apel, Cécile and Dumontet, Vincent and Robert, Aude and Groo, Anne-Claire and Litaudon, Marc and Bignon, Jérôme and Desrat, Sandy and Malzert-Fréon, Aurélie and Wiels, Joëlle and Lescop, Ewen and Roussi, Fanny

Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL-1

ChemMedChem (2021)

16, 1789-1798

10.1002/CMDC.202100011

Qiu, Jieru and Chen, Liang and Zhan, Mengsi and Laurent, Régis and Bignon, Jérôme and Mignani, Serge and Shi, Xiangyang and Caminade, Anne-Marie and Majoral, Jean-Pierre

Facile Synthesis of Amphiphilic Fluorescent Phosphorus Dendron-Based Micelles as Antiproliferative Agents: First Investigations

Bioconjugate Chemistry (2021)

32, 339-349

10.1021/ACS.BIOCONJCHEM.0C00716

Pecnard, Shannon and Provot, Olivier and Levaique, Hélène and Bignon, Jérome and Askenatzis, Laurie and Saller, Francois and Borgel, Delphine and Michallet, Sophie and Laisne, Marie-Catherine and Lafanechère, Laurence and Alami, Mouad and Hamze, Abdallah

Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation

European Journal of Medicinal Chemistry (2021)

209, 112873

10.1016/J.EJMECH.2020.112873

Labarde, Audrey and Jakutyte, Lina and Billaudeau, Cyrille and Fauler, Beatrix and López-Sanz, Maria and Ponien, Prishila and Jacquet, Eric and Mielke, Thorsten and Ayora, Silvia and Carballido-López, Rut and Tavares, Paulo

Temporal compartmentalization of viral infection in bacterial cells

Proceedings of the National Academy of Sciences (2021)

118,

10.1073/PNAS.2018297118

Listunov, Dymytrii and Joly, Etienne and Duhayon, Carine and Saffon-Merceron, Nathalie and Fabing, Isabelle and Génisson, Yves and Maraval, Valérie and Chauvin, Remi

Methinylogation Approach in Chiral Pharmacophore Design: from Alkynyl- to Allenyl-carbinol Warheads against Tumor Cells

ChemMedChem (2018)

13, 1711-1722

10.1002/CMDC.201800284

Malbert, Yannick and Moulis, Claire and Brison, Yoann and Morel, Sandrine and André, Isabelle and Remaud-Simeon, Magali

Engineering a branching sucrase for flavonoid glucoside diversification

Scientific Reports (2018)

8,

10.1038/S41598-018-33394-Y

Menchon, Grégory and Maveyraud, Laurent and Czaplicki, Georges

Molecular Dynamics as a Tool for Virtual Ligand Screening

Methods in Molecular Biology (2018)

, 145-178

10.1007/978-1-4939-7756-7_9

Rozié, Alexandrine and Santos, Cécile and Fabing, Isabelle and Calsou, Patrick and Britton, Sébastien and Génisson, Yves and Ballereau, Stéphanie

Alkyne-Tagged Analogue of Jaspine B: New Tool for Identifying Jaspine B Mode of Action

ChemBioChem (2018)

19, 2438-2442

10.1002/CBIC.201800496

Ballereau, Stéphanie and Alnazer, Heba and Castellan, Tessa and Salma, Yahya and Génisson, Yves

Enantioselective Stereodivergent Synthesis of Jaspine B and 4-epi-Jaspine B from Axially Chiral Allenols

Synlett (2019)

30, 185-188

10.1055/S-0037-1610344

Augenstreich, Jacques and Haanappel, Evert and Ferré, Guillaume and Czaplicki, Georges and Jolibois, Franck and Destainville, Nicolas and Guilhot, Christophe and Milon, Alain and Astarie-Dequeker, Catherine and Chavent, Matthieu

The conical shape of DIM lipids promotes Mycobacterium tuberculosis infection of macrophages

Proceedings of the National Academy of Sciences (2019)

116, 25649-25658

10.1073/PNAS.1910368116

Baudoin-Dehoux, Cécile and Castellan, Tessa and Rodriguez, Frédéric and Rives, Arnaud and Stauffert, Fabien and Garcia, Virginie and Levade, Thierry and Compain, Philippe and Génisson, Yves

Selective Targeting of the Interconversion between Glucosylceramide and Ceramide by Scaffold Tailoring of Iminosugar Inhibitors

Molecules (2019)

24, 354

10.3390/MOLECULES24020354

Dehoux, Cécile and Castellan, Tessa and Enel, Morgane and André-Barrès, Christiane and Mirval, Sandra and Becq, Frédéric and Ballereau, Stéphanie and Génisson, Yves

Transalpinecine and Analogues: First Total Synthesis, Stereochemical Revision and Biological Evaluation

European Journal of Organic Chemistry (2019)

2019, 1830-1834

10.1002/EJOC.201900071

Dehoux-Baudoin, Cécile and Génisson, Yves

C-Branched Imino Sugars: Synthesis and Biological Relevance

European Journal of Organic Chemistry (2019)

2019, 4765-4777

10.1002/EJOC.201900605

Ferré, Guillaume and Louet, Maxime and Saurel, Oliver and Delort, Bartholomé and Czaplicki, Georges and M'Kadmi, Céline and Damian, Marjorie and Renault, Pedro and Cantel, Sonia and Gavara, Laurent and Demange, Pascal and Marie, Jacky and Fehrentz, Jean-Alain and Floquet, Nicolas and Milon, Alain and Banères, Jean-Louis

Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain

Proceedings of the National Academy of Sciences (2019)

116, 17525-17530

10.1073/PNAS.1905105116

Ferré, Guillaume and Czaplicki, Georges and Demange, Pascal and Milon, Alain

Structure and dynamics of dynorphin peptide and its receptor

Vitamins and Hormones (2019)

, 17-47

10.1016/BS.VH.2019.05.006

Guillet, Valérie and Bordes, Patricia and Bon, Cécile and Marcoux, Julien and Gervais, Virginie and Sala, Ambre Julie and Dos Reis, Suzana and Slama, Nawel and Mares-Mejía, Israel and Cirinesi, Anne-Marie and Maveyraud, Laurent and Genevaux, Pierre and Mourey, Lionel

Structural insights into chaperone addiction of toxin-antitoxin systems

Nature Communications (2019)

10,

10.1038/S41467-019-08747-4

Ladurantie, Caroline and Coustets, Mathilde and Czaplicki, Georges and Demange, Pascal and Mazères, Serge and Dauvillier, Stéphanie and Teissié, Justin and Rols, Marie-Pierre and Milon, Alain and Ecochard, Vincent and Gross, Grégori and Paquereau, Laurent

A protein nanocontainer targeting epithelial cancers: rational engineering, biochemical characterization, drug loading and cell delivery

Nanoscale (2019)

11, 3248-3260

10.1039/C8NR10249J

Molina, Manon and Moulis, Claire and Monties, Nelly and Pizzut-Serin, Sandra and Guieysse, David and Morel, Sandrine and Cioci, Gianluca and Remaud-Siméon, Magali

Deciphering an Undecided Enzyme: Investigations of the Structural Determinants Involved in the Linkage Specificity of Alternansucrase

ACS Catalysis (2019)

9, 2222-2237

10.1021/ACSCATAL.8B04510

Pedelacq, Jean-Denis and Waldo, Geoffrey S. and Cabantous, Stéphanie

High-Throughput Protein-Protein Interaction Assays Using Tripartite Split-GFP Complementation

Methods in Molecular Biology (2019)

, 423-437

10.1007/978-1-4939-9624-7_20

Rullièrea, Pauline and Lizeauxa, François and Jolyb, Etienne and Ballereaua, Stéphanie and Gasparda, Hafida and Maravalc, Valérie and Chauvinc, Remi and Génissona, Yves

Fluorinated analogues of lipidic dialkynylcarbinol pharmacophores: synthesis and cytotoxicity in HCT116 cancer cells

French-Ukrainian Journal of Chemistry (2019)

7, 1-9

10.17721/FUJCV7I1P1-9

Arias, Maria H and Quiliano, Miguel and Bourgeade-Delmas, Sandra and Fabing, Isabelle and Chantal, Isabelle and Berthier, David and Minet, Cécile and Eparvier, Veronique and Sorres, Jonathan and Stien, Didier and Galiano, Silvia and Aldana, Ignacio and Valentin, Alexis and Garavito, Giovanny and Deharo, Eric

Alsinol, an arylamino alcohol derivative active against Plasmodium, Babesia, Trypanosoma, and Leishmania: past and new outcomes

Parasitology Research (2020)

119, 3503-3515

10.1007/S00436-020-06832-Y

Assemat, Gaëtan and Balayssac, Stéphane and Gilard, Véronique and Martins-Froment, Nathalie and Fabing, Isabelle and Rodriguez, Frédéric and Génisson, Yves and Martino, Robert and Malet-Martino, Myriam

Isolation and identification of ten new sildenafil derivatives in an alleged herbal supplement for sexual enhancement

Journal of Pharmaceutical and Biomedical Analysis (2020)

191, 113482

10.1016/J.JPBA.2020.113482

Castellan, Tessa and Santos, Cécile and Rodriguez, Frédéric and Lepage, Mathieu L. and Liang, Yan and Bodlenner, Anne and Compain, Philippe and Génisson, Yves and Dehoux, Cécile and Ballereau, Stéphanie

N,O-Dialkyl deoxynojirimycin derivatives as CERT START domain ligands

Bioorganic & Medicinal Chemistry Letters (2020)

30, 126796

10.1016/J.BMCL.2019.126796

Castellan, Tessa and Garcia, Virginie and Rodriguez, Frédéric and Fabing, Isabelle and Shchukin, Yevhenii and Tran, My Lan and Ballereau, Stéphanie and Levade, Thierry and Génisson, Yves and Dehoux, Cécile

Concise asymmetric synthesis of new enantiomericC-alkyl pyrrolidines acting as pharmacological chaperones against Gaucher disease

Organic & Biomolecular Chemistry (2020)

18, 7852-7861

10.1039/D0OB01522A

Dogan, Hilal and Dogan, Sengül Dilem and Gündüz, Miyase Gözde and Krishna, Vagolu Siva and Lherbet, Christian and Sriram, Dharmarajan and Sahin, Onur and Saripinar, Emin

Discovery of hydrazone containing thiadiazoles as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors

European Journal of Medicinal Chemistry (2020)

188, 112035

10.1016/J.EJMECH.2020.112035

Dogan, Sengül Dilem and Gündüz, Miyase Gözde and Dogan, Hilal and Krishna, Vagolu Siva and Lherbet, Christian and Sriram, Dharmarajan

Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors

European Journal of Medicinal Chemistry (2020)

199, 112402

10.1016/J.EJMECH.2020.112402

Fernández de Luco, Julia and Recio-Balsells, Alejandro I. and Ghiano, Diego G. and Bortolotti, Ana and Belardinelli, Juán Manuel and Liu, Nina and Hoffmann, Pascal and Lherbet, Christian and Tonge, Peter J. and Tekwani, Babu and Morbidoni, Héctor R. and Labadie, Guillermo R.

Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents

RSC Medicinal Chemistry (2021)

12, 120-128

10.1039/D0MD00291G

de Almeida, Diana Kelly Castro and da Silva, Marcos Reinaldo and de Mattos, Marcos Carlos and Nunes, Fátima Miranda and Ballereau, Stéphanie and Génisson, Yves and Maraval, Valérie and Chauvin, Remi and Oliveira, Maria Conceição Ferreira

Lipase-catalysed enantioselective kinetic resolution of rac-lipidic alkynylcarbinols and a C5 synthon thereof via a hydrolysis approach

Molecular Catalysis (2020)

488, 110926

10.1016/J.MCAT.2020.110926

Maveyraud, Laurent and Mourey, Lionel

Protein X-ray Crystallography and Drug Discovery

Molecules (2020)

25, 1030

10.3390/MOLECULES25051030

Pedelacq, Jean-Denis and Nguyen, Minh Chau and Terwilliger, Thomas C. and Mourey, Lionel

A Comprehensive Review onMycobacterium tuberculosisTargets and Drug Development from a Structural Perspective

Structural Biology in Drug Discovery (2020)

, 545-566

10.1002/9781118681121.CH23

Rodriguez, Frédéric and Saffon, Nathalie and Sammartino, José Camilla and Degiacomi, Giulia and Pasca, Maria Rosalia and Lherbet, Christian

First triclosan-based macrocyclic inhibitors of InhA enzyme

Bioorganic Chemistry (2020)

95, 103498

10.1016/J.BIOORG.2019.103498

Schahl, Adrien and Réat, Valérie and Jolibois, Franck

Structures and NMR spectra of short amylose-lipid complexes. Insight using molecular dynamics and DFT quantum chemical calculations

Carbohydrate Polymers (2020)

235, 115846

10.1016/J.CARBPOL.2020.115846

Tournier, V. and Topham, C. M. and Gilles, A. and David, B. and Folgoas, C. and Moya-Leclair, E. and Kamionka, E. and Desrousseaux, M.-L. and Texier, H. and Gavalda, S. and Cot, M. and Guémard, E. and Dalibey, M. and Nomme, J. and Cioci, G. and Barbe, S. and Chateau, M. and André, I. and Duquesne, S. and Marty, A.

An engineered PET depolymerase to break down and recycle plastic bottles

Nature (2020)

580, 216-219

10.1038/S41586-020-2149-4

Tran, My Lan and Génisson, Yves and Ballereau, Stéphanie and Dehoux, Cécile

Second-Generation Pharmacological Chaperones: Beyond Inhibitors

Molecules (2020)

25, 3145

10.3390/MOLECULES25143145

Wu, Haiyang and Ioannou, Eleni and Henrissat, Bernard and Montanier, Cédric Y. and Bozonnet, Sophie and O'Donohue, Michael J. and Dumon, Claire

Multimodularity of a GH10 Xylanase Found in the Termite Gut Metagenome

Applied and Environmental Microbiology (2021)

87,

10.1128/AEM.01714-20

Baybekov, Shamkhal and Marcou, Gilles and Ramos, Pascal and Saurel, Olivier and Galzi, Jean-Luc and Varnek, Alexandre

DMSO Solubility Assessment for Fragment-Based Screening

Molecules (2021)

26, 3950

10.3390/MOLECULES26133950

Benkoulouche, Mounir and Ben Imeddourene, Akli and Barel, Louis-Antoine and Le Heiget, Guillaume and Pizzut, Sandra and Kulyk, Hanna and Bellvert, Floriant and Bozonnet, Sophie and Mulard, Laurence A. and Remaud-Siméon, Magali and Moulis, Claire and André, Isabelle

Redirecting substrate regioselectivity using engineered deltaN123-GBD-CD2 branching sucrases for the production of pentasaccharide repeating units of S. flexneri 3a, 4a and 4b haptens

Scientific Reports (2021)

11,

10.1038/S41598-021-81719-1

Benkoulouche, Mounir and Ben Imeddourene, Akli and Barel, Louis-Antoine and Lefebvre, Dorian and Fanuel, Mathieu and Rogniaux, Hélène and Ropartz, David and Barbe, Sophie and Guieysse, David and Mulard, Laurence A. and Remaud-Siméon, Magali and Moulis, Claire and André, Isabelle

Computer-aided engineering of a branching sucrase for the glucodiversification of a tetrasaccharide precursor of S. flexneri antigenic oligosaccharides

Scientific Reports (2021)

11,

10.1038/S41598-021-99384-9

Borie-Guichot, Marc and Tran, My Lan and Génisson, Yves and Ballereau, Stéphanie and Dehoux, Cécile

Pharmacological Chaperone Therapy for Pompe Disease

Molecules (2021)

26, 7223

10.3390/MOLECULES26237223

Carivenc, Coralie and Maveyraud, Laurent and Blanger, Claire and Ballereau, Stéphanie and Roy-Camille, Coralie and Nguyen, Minh Chau and Génisson, Yves and Guilhot, Christophe and Chalut, Christian and Pedelacq, Jean-Denis and Mourey, Lionel

Phosphopantetheinyl transferase binding and inhibition by amidino-urea and hydroxypyrimidinethione compounds

Scientific Reports (2021)

11,

10.1038/S41598-021-97197-4

Farjallah, Asma and Chiarelli, Laurent R. and Forbak, Martin and Degiacomi, Giulia and Danel, Mathieu and Goncalves, Fernanda and Carayon, Chantal and Seguin, Cendrine and Fumagalli, Marco and Záhorszká, Monika and Vega, Elodie and Abid, Souhir and Grzegorzewicz, Anna and Jackson, Mary and Peixoto, Antonio and Korduláková, Jana and Pasca, Maria Rosalia and Lherbet, Christian and Chassaing, Stefan

A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis

ACS Infectious Diseases (2021)

7, 552-565

10.1021/ACSINFECDIS.0C00325

Galy, Romain and Ballereau, Stéphanie and Génisson, Yves and Mourey, Lionel and Plaquevent, Jean-Christophe and Maveyraud, Laurent

Fragment-Based Ligand Discovery Applied to the Mycolic Acid Methyltransferase Hma (MmaA4) from Mycobacterium tuberculosis: A Crystallographic and Molecular Modelling Study

Pharmaceuticals (2021)

14, 1282

10.3390/PH14121282

Gherbovet, Olga and Ferreira, Fernando and Clément, Apolline and Ragon, Mélanie and Durand, Julien and Bozonnet, Sophie and O'Donohue, Michael J and Fauré, Régis

Regioselective chemoenzymatic syntheses of ferulate conjugates as chromogenic substrates for feruloyl esterases

Beilstein Journal of Organic Chemistry (2021)

17, 325-333

10.3762/BJOC.17.30

Javaid, Sumaira and Zafar, Humaira and Atia-tul-Wahab and Gervais, Virginie and Ramos, Pascal and Muller, Isabelle and Milon, Alain and Atta-ur-Rahman and Choudhary, M. Iqbal

Identification of new lead molecules against anticancer drug target TFIIH subunit P8 using biophysical and molecular docking studies

Bioorganic Chemistry (2021)

114, 105021

10.1016/J.BIOORG.2021.105021

Mouhtady, Omar and Castellan, Tessa and André-Barrès, Christiane and Gornitzka, Heinz and Fabing, Isabelle and Saffon-Merceron, Nathalie and Génisson, Yves and Gaspard, Hafida

(R)-BINOL-6,6'-bistriflone: Shortened Synthesis, Characterization, and Enantioselective Catalytic Applications

European Journal of Organic Chemistry (2021)

2021, 6674-6681

10.1002/EJOC.202101137

Koçak Aslan, Ebru and Han, Muhammed Ihsan and Krishna, Vagolu Siva and Tamhaev, Rasoul and Dengiz, Cagatay and Dogan, Sengül Dilem and Lherbet, Christian and Mourey, Lionel and Tønjum, Tone and Gündüz, Miyase Gözde

Isoniazid Linked to Sulfonate Esters via Hydrazone Functionality: Design, Synthesis, and Evaluation of Antitubercular Activity

Pharmaceuticals (2022)

15, 1301

10.3390/PH15101301

Keles Atici, Rüveyde and Dogan, Sengül Dilem and Gündüz, Miyase Gözde and Krishna, Vagolu Siva and Chebaiki, Melina and Homberset, Håvard and Lherbet, Christian and Mourey, Lionel and Tønjum, Tone

Urea derivatives carrying a thiophenylthiazole moiety: Design, synthesis, and evaluation of antitubercular and InhA inhibitory activities

Drug Development Research (2022)

83, 1292-1304

10.1002/DDR.21958

Demange, Pascal and Joly, Etienne and Marcoux, Julien and Zanon, Patrick RA and Listunov, Dymytrii and Rullière, Pauline and Barthes, Cécile and Noirot, Céline and Izquierdo, Jean-Baptiste and Rozié, Alexandrine and Pradines, Karen and Hee, Romain and de Brito, Maria Vieira and Marcellin, Marlène and Serre, Remy-Felix and Bouchez, Olivier and Burlet-Schiltz, Odile and Oliveira, Maria Conceição Ferreira and Ballereau, Stéphanie and Bernardes-Génisson, Vania and Maraval, Valérie and Calsou, Patrick and Hacker, Stephan M and Génisson, Yves and Chauvin, Remi and Britton, Sébastien

SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

eLife (2022)

11,

10.7554/ELIFE.73913

Le, Nguyen-Hung and Constant, Patricia and Tranier, Samuel and Nahoum, Virginie and Guillet, Valérie and Maveyraud, Laurent and Daffé, Mamadou and Mourey, Lionel and Verhaeghe, Pierre and Marrakchi, Hedia

Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis

Bioorganic & Medicinal Chemistry (2022)

71, 116938

10.1016/J.BMC.2022.116938

Li, Ao and Benkoulouche, Mounir and Ladeveze, Simon and Durand, Julien and Cioci, Gianluca and Laville, Elisabeth and Potocki-Veronese, Gabrielle

Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases

International Journal of Molecular Sciences (2022)

23, 3043

10.3390/IJMS23063043

Mansour, Moise and Giudice, Emmanuel and Xu, Xibing and Akarsu, Hatice and Bordes, Patricia and Guillet, Valérie and Bigot, Donna-Joe and Slama, Nawel and D'urso, Gaetano and Chat, Sophie and Redder, Peter and Falquet, Laurent and Mourey, Lionel and Gillet, Reynald and Genevaux, Pierre

Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis

Nature Communications (2022)

13,

10.1038/S41467-022-30373-W

Tapera, Michael and Kekeçmuhammed, Hüseyin and Sahin, Kader and Krishna, Vagolu Siva and Lherbet, Christian and Homberset, Håvard and Chebaiki, Mélina and Tønjum, Tone and Mourey, Lionel and Zorlu, Yunus and Durdagi, Serdar and Saripinar, Emin

Synthesis, characterization, anti-tuberculosis activity and molecular modeling studies of thiourea derivatives bearing aminoguanidine moiety

Journal of Molecular Structure (2022)

1270, 133899

10.1016/J.MOLSTRUC.2022.133899

Tomas, Nicolas and Leonelli, Dimitri and Campoy, Martin and Marthey, Sylvain and Le, Nguyen-Hung and Rengel, David and Martin, Véronique and Pál, Adrian and Korduláková, Jana and Eynard, Nathalie and Guillet, Valérie and Mourey, Lionel and Daffé, Mamadou and Lemassu, Anne and André, Gwenaëlle and Marrakchi, Hedia

Bioinformatic Mining and Structure-Activity Profiling of Baeyer-Villiger Monooxygenases from Mycobacterium tuberculosis

mSphere (2022)

7,

10.1128/MSPHERE.00482-21

Pritzlaff, Amanda and Ferré, Guillaume and Mulry, Emma and Lin, Ling and Gopal Pour, Niloofar and Savin, Daniel A. and Harris, Michael E. and Eddy, Matthew T.

Atomic-Scale View of Protein-PEG Interactions that Redirect the Thermal Unfolding Pathway of PEGylated Human Galectin-3

Angewandte Chemie International Edition (2022)

61,

10.1002/ANIE.202203784

Lauressergues, Dominique and Ormancey, Mélanie and Guillotin, Bruno and San Clemente, Hélène and Camborde, Laurent and Duboé, Carine and Tourneur, Sabine and Charpentier, Pierre and Barozet, Amélie and Jauneau, Alain and Le Ru, Aurélie and Thuleau, Patrice and Gervais, Virginie and Plaza, Serge and Combier, Jean-Philippe

Characterization of plant microRNA-encoded peptides (miPEPs) reveals molecular mechanisms from the translation to activity and specificity

Cell Reports (2022)

38, 110339

10.1016/J.CELREP.2022.110339

Castillo, Sebastian and Gence, Rémi and Pagan, Delphine and Koraïchi, Faten and Bouchenot, Catherine and Pons, Benoit J. and Boëlle, Betty and Olichon, Aurélien and Lajoie-Mazenc, Isabelle and Favre, Gilles and Pédelacq, Jean-Denis and Cabantous, Stéphanie

Visualizing the subcellular localization of RHOB-GTP and GTPase-Effector complexes using a split-GFP/nanobody labelling assay

European Journal of Cell Biology (2023)

102, 151355

10.1016/J.EJCB.2023.151355

Chebaiki, Mélina and Delfourne, Evelyne and Tamhaev, Rasoul and Danoun, Saïda and Rodriguez, Frédéric and Hoffmann, Pascal and Grosjean, Emeline and Goncalves, Fernanda and Azéma-Despeyroux, Joëlle and Pál, Adrián and Korduláková, Jana and Preuilh, Nadège and Britton, Sébastien and Constant, Patricia and Marrakchi, Hedia and Maveyraud, Laurent and Mourey, Lionel and Lherbet, Christian

Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA

European Journal of Medicinal Chemistry (2023)

259, 115646

10.1016/J.EJMECH.2023.115646

Khamassi, Ahmed and Dumon, Claire

Enzyme synergy for plant cell wall polysaccharide degradation

Essays in Biochemistry (2023)

67, 521-531

10.1042/EBC20220166

Pritzlaff, Amanda and Ferré, Guillaume and Dargassies, Elia and Williams, Crystal O. and Gonzalez, Daniel D. and Eddy, Matthew T.

Conserved Protein-Polymer Interactions across Structurally Diverse Polymers Underlie Alterations to Protein Thermal Unfolding

ACS Central Science (2023)

9, 685-695

10.1021/ACSCENTSCI.2C01522

Ferré, Guillaume and Gomes, Antoniel A.S. and Louet, Maxime and Damian, Marjorie and Bisch, Paulo M. and Saurel, Olivier and Floquet, Nicolas and Milon, Alain and Banères, Jean-Louis

Sodium is a negative allosteric regulator of the ghrelin receptor

Cell Reports (2023)

42, 112320

10.1016/J.CELREP.2023.112320

Dingis Birgül, Serap Ipek and Kumari, Jyothi and Tamhaev, Rasoul and Mourey, Lionel and Lherbet, Christian and Sriram, Dharmarajan and Akdemir, Atilla and Küçükgüzel, Ilkay

In silico design, synthesis and antitubercular activity of novel 2-acylhydrazono-5-arylmethylene-4-thiazolidinones as enoyl-acyl carrier protein reductase inhibitors

Journal of Biomolecular Structure and Dynamics (2024)

, 1-19

10.1080/07391102.2024.2319678

Tamhaev, Rasoul and Grosjean, Emeline and Ahamed, Hikmat and Chebaiki, Mélina and Rodriguez, Frédéric and Recchia, Deborah and Degiacomi, Giulia and Pasca, Maria Rosalia and Maveyraud, Laurent and Mourey, Lionel and Lherbet, Christian

Exploring the plasticity of the InhA substrate-binding site using new diaryl ether inhibitors

Bioorganic Chemistry (2024)

143, 107032

10.1016/J.BIOORG.2023.107032

Venugopala, Katharigatta N. and Chandrashekharappa, Sandeep and Deb, Pran Kishore and Al-Shar'i, Nizar A. and Pillay, Melendhran and Tiwari, Priya and Chopra, Deepak and Borah, Pobitra and Tamhaev, Rasoul and Mourey, Lionel and Lherbet, Christian and Aldhubiab, Bandar E. and Tratrat, Christophe and Attimarad, Mahesh and Nair, Anroop B. and Sreeharsha, Nagaraja and Mailavaram, Raghu Prasad and Venugopala, Rashmi and Mohanlall, Viresh and Morsy, Mohamed A.

Identification of potent indolizine derivatives against Mycobacterial tuberculosis: In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies

International Journal of Biological Macromolecules (2024)

274, 133285

10.1016/J.IJBIOMAC.2024.133285

Guicherd, M. and Ben Khaled, M. and Guéroult, M. and Nomme, J. and Dalibey, M. and Grimaud, F. and Alvarez, P. and Kamionka, E. and Gavalda, S. and Noël, M. and Vuillemin, M. and Amillastre, E. and Labourdette, D. and Cioci, G. and Tournier, V. and Kitpreechavanich, V. and Dubois, P. and André, I. and Duquesne, S. and Marty, A.

An engineered enzyme embedded into PLA to make self-biodegradable plastic

Nature (2024)

631, 884-890

10.1038/S41586-024-07709-1

Noriega, Maxime and Corey, Robin A. and Haanappel, Evert and Demange, Pascal and Czaplicki, Georges and Atkinson, R. Andrew and Chavent, Matthieu

Coarse-Graining the Recognition of a Glycolipid by the C-Type Lectin Mincle Receptor

The Journal of Physical Chemistry B (2024)

128, 9935-9946

10.1021/ACS.JPCB.4C03242

Menchon, Grégory and Maveyraud, Laurent and Czaplicki, Georges

Molecular Dynamics as a Tool for Virtual Ligand Screening

Methods in Molecular Biology (2024)

, 33-83

10.1007/978-1-0716-3441-7_3

Rizet, Julien and Maveyraud, Laurent and Rengel, David and Guillet, Valérie and Publicola, Gabriel and Rodriguez, Frédéric and Lherbet, Christian and Mourey, Lionel

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem (2025)

20,

10.1002/CMDC.202500079

Petracco, Enzo and Ferré, Guillaume and Kabelka, Ivo and Ballante, Flavio and Carlsson, Jens and Mulry, Emma and Ray, Arka P. and Collins, James and Allais, Florent and Eddy, Matthew T.

Development of an In Situ G Protein-Coupled Receptor Fragment Molecule Screening Approach with High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance

ACS Chemical Biology (2025)

20, 401-411

10.1021/ACSCHEMBIO.4C00686

Le Garrec, Stéphen and Fabing, Isabelle and Toppan, Caroline and Lavedan, Pierre and Wolff, Mariusz and Benoist, Eric and Fery-Forgues, Suzanne and Bedos-Belval, Florence

Separation and characterization of the various stereoisomers of a dinuclear tricarbonylrhenium(I) complex using a theoretical and experimental approach

Analytica Chimica Acta (2025)

1346, 343749

10.1016/J.ACA.2025.343749

Gelot, Camille and Kovacs, Marton Tibor and Miron, Simona and Mylne, Emilie and Haan, Alexis and Boeffard-Dosierre, Liza and Ghouil, Rania and Popova, Tatiana and Dingli, Florent and Loew, Damarys and Guirouilh-Barbat, Josée and Del Nery, Elaine and Zinn-Justin, Sophie and Ceccaldi, Raphael

Poltheta is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Nature (2023)

621, 415-422

10.1038/S41586-023-06506-6

Dumas, Elise and Grandal Rejo, Beatriz and Gougis, Paul and Houzard, Sophie and Abécassis, Judith and Jochum, Floriane and Marande, Benjamin and Ballesta, Annabelle and Del Nery, Elaine and Dubois, Thierry and Alsafadi, Samar and Asselain, Bernard and Latouche, Aurélien and Espie, Marc and Laas, Enora and Coussy, Florence and Bouchez, Clémentine and Pierga, Jean-Yves and Le Bihan-Benjamin, Christine and Bousquet, Philippe-Jean and Hotton, Judicaël and Azencott, Chloé-Agathe and Reyal, Fabien and Hamy, Anne-Sophie

Concomitant medication, comorbidity and survival in patients with breast cancer

Nature Communications (2024)

15,

10.1038/S41467-024-47002-3

Tucker, Elizabeth R. and Jiménez, Irene and Chen, Lindi and Bellini, Angela and Gorrini, Chiara and Calton, Elizabeth and Gao, Qiong and Che, Harvey and Poon, Evon and Jamin, Yann and Martins Da Costa, Barbara and Barker, Karen and Shrestha, Sumana and Hutchinson, J. Ciaran and Dhariwal, Simran and Goodman, Angharad and Del Nery, Elaine and Gestraud, Pierre and Bhalshankar, Jaydutt and Iddir, Yasmine and Saberi-Ansari, Elnaz and Saint-Charles, Alexandra and Geoerger, Birgit and Marques Da Costa, Maria Eugénia and Pierre-Eugène, Cécile and Janoueix-Lerosey, Isabelle and Decaudin, Didier and Nemati, Fariba and Carcaboso, Angel M. and Surdez, Didier and Delattre, Olivier and George, Sally L. and Chesler, Louis and Tweddle, Deborah A. and Schleiermacher, Gudrun

Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models

Clinical Cancer Research (2023)

29, 1317-1331

10.1158/1078-0432.CCR-22-2274

Chabanon, Roman M. and Morel, Daphné and Eychenne, Thomas and Colmet-Daage, Léo and Bajrami, Ilirjana and Dorvault, Nicolas and Garrido, Marlène and Meisenberg, Cornelia and Lamb, Andrew and Ngo, Carine and Hopkins, Suzanna R. and Roumeliotis, Theodoros I. and Jouny, Samuel and Hénon, Clémence and Kawai-Kawachi, Asuka and Astier, Clémence and Konde, Asha and Del Nery, Elaine and Massard, Christophe and Pettitt, Stephen J. and Margueron, Raphaël and Choudhary, Jyoti S. and Almouzni, Geneviève and Soria, Jean-Charles and Deutsch, Eric and Downs, Jessica A. and Lord, Christopher J. and Postel-Vinay, Sophie

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Cancer Research (2021)

81, 2888-2902

10.1158/0008-5472.CAN-21-0628

Cohen, Ethan and Corbe, Maxime and Franco, Cláudio A. and Vasconcelos, Francisca F. and Perez, Franck and Del Nery, Elaine and Bollot, Guillaume and Genovesio, Auguste

Cell painting transfer increases screening hit rate

Biological Imaging (2023)

3,

10.1017/S2633903X23000077

Abu-Helo, Alaa and Daubeuf, François and Tranchant, Thibaud and Lehalle, Christine and Elhabazi, Khadija and Zeder-Lutz, Gabrielle and Kugler, Valérie and Lugnier, Claire and Frossard, Nelly and Lecat, Sandra and Simonin, Frédéric

GPRASP1 deletion in mice abrogates adverse side effects associated with chronic stimulation of Beta2-adrenoceptor

Biomedicine & Pharmacotherapy (2025)

187, 118073

10.1016/J.BIOPHA.2025.118073

Boos, Agathe and Most, Julien and Cahuzac, Héloïse and Moreira da Silva, Louis and Daubeuf, François and Erb, Stéphane and Cianférani, Sarah and Hernandez-Alba, Oscar and Semenchenko, Constantin and Dovgan, Igor and Kolodych, Sergii and Detappe, Alexandre and Dantzer, Françoise and Wagner, Alain and Zeniou, Maria and Chaubet, Guilhem

Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents

Journal of Medicinal Chemistry (2025)

68, 695-705

10.1021/ACS.JMEDCHEM.4C02425

Girault-Sotias, Pierre-Emmanuel and Deloux, Robin and De Mota, Nadia and Riché, Stephanie and Daubeuf, François and Iturrioz, Xavier and Parlakian, Ara and Berdeaux, Alain and Agbulut, Onnik and Bonnet, Dominique and Boitard, Solène Emmanuelle and Llorens-Cortes, Catherine

The Metabolically Resistant Apelin-17 Analogue LIT01-196 Reduces Cardiac Dysfunction and Remodelling in Heart Failure After Myocardial Infarction

Canadian Journal of Cardiology (2025)

41, 911-924

10.1016/J.CJCA.2024.11.034

Jouvenel, Antoine and Tassou, Adrien and Thouaye, Maxime and Ruel, Jérôme and Antri, Myriam and Leyris, Jean-Philippe and Giraudin, Aurore and Mallié, Sylvie and Sar, Chamroeum and Diouloufet, Lucie and Sonrier, Corinne and Daubeuf, François and Bertin, Juliette and Alves, Stacy and Ventéo, Stéphanie and Frossard, Nelly and Carroll, Patrick and Mechaly, Ilana and Rognan, Didier and Sokoloff, Pierre and Dallel, Radhouane and Delmas, Patrick and Valmier, Jean and Rivat, Cyril

FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia

Nature Communications (2024)

15,

10.1038/S41467-024-54054-Y

De Neve, Jolien and Elhabazi, Khadija and Gonzalez, Simon and Herby, Claire and Schneider, Séverine and Utard, Valérie and Fellmann-Clauss, Rosine and Petit-Demouliere, Nathalie and Lecat, Sandra and Kremer, Mélanie and Ces, Aurelia and Daubeuf, François and Martin, Charlotte and Ballet, Steven and Bihel, Frédéric and Simonin, Frédéric

Multitarget micro-Opioid Receptor Agonists-Neuropeptide FF Receptor Antagonists Induce Potent Antinociception with Reduced Adverse Side Effects

Journal of Medicinal Chemistry (2024)

67, 7603-7619

10.1021/ACS.JMEDCHEM.4C00442

Baybekov, Shamkhal and Llompart, Pierre and Marcou, Gilles and Gizzi, Patrick and Galzi, Jean-Luc and Ramos, Pascal and Saurel, Olivier and Bourban, Claire and Minoletti, Claire and Varnek, Alexandre

Kinetic solubility: Experimental and machine-learning modeling perspectives

Molecular Informatics (2024)

43,

10.1002/MINF.202300216

Lehot, Victor and Neuberg, Patrick and Ripoll, Manon and Daubeuf, François and Erb, Stéphane and Dovgan, Igor and Ursuegui, Sylvain and Cianférani, Sarah and Kichler, Antoine and Chaubet, Guilhem and Wagner, Alain

Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles

Pharmaceutics (2023)

15, 1643

10.3390/PHARMACEUTICS15061643

Leroy, Catherine and Spelier, Sacha and Essonghe, Nadège Charlene and Poix, Virginie and Kong, Rebekah and Gizzi, Patrick and Bourban, Claire and Amand, Séverine and Bailly, Christine and Guilbert, Romain and Hannebique, David and Persoons, Philippe and Arhant, Gwenaëlle and Prévotat, Anne and Reix, Philippe and Hubert, Dominique and Gérardin, Michèle and Chamaillard, Mathias and Prevarskaya, Natalia and Rebuffat, Sylvie and Shapovalov, George and Beekman, Jeffrey and Lejeune, Fabrice

Use of 2,6-diaminopurine as a potent suppressor of UGA premature stop codons in cystic fibrosis

Molecular Therapy (2023)

31, 970-985

10.1016/J.YMTHE.2023.01.014

Rady, Tony and Turelli, Lorenzo and Nothisen, Marc and Tobaldi, Elisabetta and Erb, Stéphane and Thoreau, Fabien and Hernandez-Alba, Oscar and Cianferani, Sarah and Daubeuf, François and Wagner, Alain and Chaubet, Guilhem

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity

Bioconjugate Chemistry (2022)

33, 1860-1866

10.1021/ACS.BIOCONJCHEM.2C00314

Segaud, Justine and Yao, Wenjin and Marschall, Pierre and Daubeuf, François and Lehalle, Christine and German, Beatriz and Meyer, Pierre and Hener, Pierre and Hugel, Cécile and Flatter, Eric and Guivarch, Marine and Clauss, Laetitia and Martin, Stefan F. and Oulad-Abdelghani, Mustapha and Li, Mei

Context-dependent function of TSLP and IL-1ß in skin allergic sensitization and atopic march

Nature Communications (2022)

13,

10.1038/S41467-022-32196-1

Schall, Nicolas and Daubeuf, François and Marsol, Claire and Gizzi, Patrick and Frossard, Nelly and Bonnet, Dominique and Galzi, Jean-Luc and Muller, Sylviane

A Selective Neutraligand for CXCL12/SDF-1alpha With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice

Frontiers in Pharmacology (2021)

12,

10.3389/FPHAR.2021.752194

Daubeuf, François and Schall, Nicolas and Petit-Demoulière, Nathalie and Frossard, Nelly and Muller, Sylviane

An Autophagy Modulator Peptide Prevents Lung Function Decrease and Corrects Established Inflammation in Murine Models of Airway Allergy

Cells (2021)

10, 2468

10.3390/CELLS10092468

Mascret, Aïda and Mouhsine, Hadley and Attia, Ghada and Cabrera, Damien and Benchekroun, Mohamed and Gizzi, Patrick and Zerrouki, Chouki and Fourati, Najla and Zagury, Jean-François and Veitía, Maité Sylla-Iyarreta and Port, Marc

New contributions to the drug profile of TNFalpha inhibitor SPD304: Affinity, selectivity and ADMET considerations

European Journal of Pharmacology (2021)

907, 174285

10.1016/J.EJPHAR.2021.174285

Mertes, Paul-Michel and Collange, Olivier and Coliat, Pierre and Banerjee, Mainak and Diringer, Marie-Charlotte and Roche, Anne and Delabranche, Xavier and Chaban, Vitaliy and Voegelin, Manon and Bernard, Alexandre and Sartori, Valérie and Laurent, Nina and Velten, Michel and Dhindsa, Navreet and Defuria, Jason and Kim, Gwangseong and Xu, Zhenghong Hannah and Theodorou, Marina and Huang, Zhaohua Richard and Khalifa, Kaniz and Geng, Bolin and Niyikiza, Clet and Moyo, Victor and Gizzi, Patrick and Villa, Pascal and Detappe, Alexandre and Pivot, Xavier

Liposomal encapsulation of trans-crocetin enhances oxygenation in patients with COVID-19-related ARDS receiving mechanical ventilation

Journal of Controlled Release (2021)

336, 252-261

10.1016/J.JCONREL.2021.06.033

Quillet, Raphaëlle and Schneider, Séverine and Utard, Valérie and Drieu la Rochelle, Armand and Elhabazi, Khadija and Henningsen, Jo Beldring and Gizzi, Patrick and Schmitt, Martine and Kugler, Valérie and Simonneaux, Valérie and Ilien, Brigitte and Simonin, Frédéric and Bihel, Frédéric

Identification of an N-acylated-DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia

Journal of Medicinal Chemistry (2021)

64, 7555-7564

10.1021/ACS.JMEDCHEM.1C00256

Fourmois, Laura and Poyer, Florent and Sourdon, Aude and Naud-Martin, Delphine and Nagarajan, Sounderya and Chennoufi, Rahima and Deprez, Eric and Teulade-Fichou, Marie-Paule and Mahuteau-Betzer, Florence

Modulation of Cellular Fate of Vinyl Triarylamines through Structural Fine Tuning: To Stay or Not To Stay in the Mitochondria?

ChemBioChem (2021)

22, 2457-2467

10.1002/CBIC.202100168

Virlogeux, Amandine and Scaramuzzino, Chiara and Lenoir, Sophie and Carpentier, Rémi and Louessard, Morgane and Genoux, Aurélie and Lino, Patricia and Hinckelmann, Maria-Victoria and Perrier, Anselme L. and Humbert, Sandrine and Saudou, Frédéric

Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice

Science Advances (2021)

7,

10.1126/SCIADV.ABB0799

Daubeuf, François and Frossard, Nelly

Eosinophils in Asthma Models to House Dust Mite for Drug Development

Methods in Molecular Biology (2021)

, 75-87

10.1007/978-1-0716-1095-4_7

Flahault, Adrien and Girault-Sotias, Pierre-Emmanuel and Keck, Mathilde and Alvear-Perez, Rodrigo and De Mota, Nadia and Estéoulle, Lucie and Ramanoudjame, Sridévi M. and Iturrioz, Xavier and Bonnet, Dominique and Llorens-Cortes, Catherine

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia

Nature Communications (2021)

12,

10.1038/S41467-020-20560-Y

Tang, Shuang-Qi and Leloire, Maeva and Schneider, Séverine and Mohr, Julie and Bricard, Jacques and Gizzi, Patrick and Garnier, Delphine and Schmitt, Martine and Bihel, Frédéric

Diastereoselective Synthesis of Nonplanar 3-Amino-1,2,4-oxadiazine Scaffold: Structure Revision of Alchornedine

The Journal of Organic Chemistry (2020)

85, 15347-15359

10.1021/ACS.JOC.0C01764

Esteoulle, Lucie and Daubeuf, François and Collot, Mayeul and Riché, Stéphanie and Durroux, Thierry and Brasse, David and Marchand, Patrice and Karpenko, Julie and Klymchenko, Andrey S. and Bonnet, Dominique

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice

Chemical Science (2020)

11, 6824-6829

10.1039/D0SC01018A

Fichez, Jeanne and Soulie, Cathia and Le Corre, Laurent and Sayon, Sophie and Priet, Stéphane and Alvarez, Karine and Delelis, Olivier and Gizzi, Patrick and Prestat, Guillaume and Gravier-Pelletier, Christine and Marcelin, Anne-Geneviève and Calvez, Vincent and Busca, Patricia

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor

RSC Medicinal Chemistry (2020)

11, 577-582

10.1039/D0MD00025F

Hilfiger, Louis and Zhao, Qian and Kerspern, Damien and Inquimbert, Perrine and Andry, Virginie and Goumon, Yannick and Darbon, Pascal and Hibert, Marcel and Charlet, Alexandre

A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain

Scientific Reports (2020)

10,

10.1038/S41598-020-59929-W

Hua, Guoqiang and Zein, Naimah and Daubeuf, François and Chambon, Pierre

Glucocorticoid receptor modulators CpdX and CpdX-D3 exhibit the same in vivo antiinflammatory activities as synthetic glucocorticoids

Proceedings of the National Academy of Sciences (2019)

116, 14191-14199

10.1073/PNAS.1908258116

Drieu la Rochelle, Armand and Guillemyn, Karel and Dumitrascuta, Maria and Martin, Charlotte and Utard, Valérie and Quillet, Raphaëlle and Schneider, Séverine and Daubeuf, François and Willemse, Tom and Mampuys, Pieter and Maes, Bert U.W. and Frossard, Nelly and Bihel, Frédéric and Spetea, Mariana and Simonin, Frédéric and Ballet, Steven

A bifunctional-biased mu-opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects

Pain (2018)

159, 1705-1718

10.1097/J.PAIN.0000000000001262

Cam, Morgane and Durieu, Emilie and Bodin, Marion and Manousopoulou, Antigoni and Koslowski, Svenja and Vasylieva, Natalia and Barnych, Bogdan and Hammock, Bruce D. and Bohl, Bettina and Koch, Philipp and Omori, Chiori and Yamamoto, Kazuo and Hata, Saori and Suzuki, Toshiharu and Karg, Frank and Gizzi, Patrick and Erakovic Haber, Vesna and Bencetic Mihaljevic, Vlatka and Tavcar, Branka and Portelius, Erik and Pannee, Josef and Blennow, Kaj and Zetterberg, Henrik and Garbis, Spiros D. and Auvray, Pierrick and Gerber, Hermeto and Fraering, Jeremy and Fraering, Patrick C. and Meijer, Laurent

Induction of Amyloid-ß42 Production by Fipronil and Other Pyrazole Insecticides

Journal of Alzheimer's Disease (2018)

62, 1663-1681

10.3233/JAD-170875

Feng, Liwen and Lanfranchi, Don Antoine and Cotos, Leandro and Cesar-Rodo, Elena and Ehrhardt, Katharina and Goetz, Alice-Anne and Zimmermann, Herbert and Fenaille, François and Blandin, Stephanie A. and Davioud-Charvet, Elisabeth

Synthesis of plasmodione metabolites and13C-enriched plasmodione as chemical tools for drug metabolism investigation

Organic & Biomolecular Chemistry (2018)

16, 2647-2665

10.1039/C8OB00227D

Quignot, Chloé and Rey, Julien and Yu, Jinchao and Tufféry, Pierre and Guerois, Raphaël and Andreani, Jessica

InterEvDock2: an expanded server for protein docking using evolutionary and biological information from homology models and multimeric inputs

Nucleic Acids Research (2018)

46, W408-W416

10.1093/NAR/GKY377

Stratmann, Dirk and Pathmanathan, Jananan S. and Postic, Guillaume and Rey, Julien and Chomilier, Jacques

TEF 2.0: a graph-based method for decomposing protein structures into closed loops

Journal of Biomolecular Structure and Dynamics (2019)

37, 4140-4150

10.1080/07391102.2018.1546230

Karami, Yasaman and Rey, Julien and Postic, Guillaume and Murail, Samuel and Tufféry, Pierre and de Vries, Sjoerd J

DaReUS-Loop: a web server to model multiple loops in homology models

Nucleic Acids Research (2019)

47, W423-W428

10.1093/NAR/GKZ403

Rey, Julien and Rasolohery, Inès and Tufféry, Pierre and Guyon, Frédéric and Moroy, Gautier

PatchSearch: a web server for off-target protein identification

Nucleic Acids Research (2019)

47, W365-W372

10.1093/NAR/GKZ478

Lagarde, Nathalie and Goldwaser, Elodie and Pencheva, Tania and Jereva, Dessislava and Pajeva, Ilza and Rey, Julien and Tuffery, Pierre and Villoutreix, Bruno O. and Miteva, Maria A.

A Free Web-Based Protocol to Assist Structure-Based Virtual Screening Experiments

International Journal of Molecular Sciences (2019)

20, 4648

10.3390/IJMS20184648

Postic, Guillaume and Andreani, Jessica and Marcoux, Julien and Reys, Victor and Guerois, Raphaël and Rey, Julien and Mouton-Barbosa, Emmanuelle and Vandenbrouck, Yves and Cianferani, Sarah and Burlet-Schiltz, Odile and Labesse, Gilles and Tufféry, Pierre

Proteo3Dnet: a web server for the integration of structural information with interactomics data

Nucleic Acids Research (2021)

49, W567-W572

10.1093/NAR/GKAB332

Quignot, Chloé and Postic, Guillaume and Bret, Hélène and Rey, Julien and Granger, Pierre and Murail, Samuel and Chacón, Pablo and Andreani, Jessica and Tufféry, Pierre and Guerois, Raphaël

InterEvDock3: a combined template-based and free docking server with increased performance through explicit modeling of complex homologs and integration of covariation-based contact maps

Nucleic Acids Research (2021)

49, W277-W284

10.1093/NAR/GKAB358

Murail, Samuel and de Vries, Sjoerd J. and Rey, Julien and Moroy, Gautier and Tufféry, Pierre

SeamDock: An Interactive and Collaborative Online Docking Resource to Assist Small Compound Molecular Docking

Frontiers in Molecular Biosciences (2021)

8,

10.3389/FMOLB.2021.716466

Rey, Julien and Murail, Samuel and de Vries, Sjoerd and Derreumaux, Philippe and Tuffery, Pierre

PEP-FOLD4: a pH-dependent force field for peptide structure prediction in aqueous solution

Nucleic Acids Research (2023)

51, W432-W437

10.1093/NAR/GKAD376

Barbault, Florent and Brémond, Eric and Rey, Julien and Tufféry, Pierre and Maurel, François

DockSurf: A Molecular Modeling Software for the Prediction of Protein/Surface Adhesion

Journal of Chemical Information and Modeling (2023)

63, 5220-5231

10.1021/ACS.JCIM.3C00569

Garcia-Lopez, Amparo and Tessaro, Francesca and Jonker, Hendrik R. A. and Wacker, Anna and Richter, Christian and Comte, Arnaud and Berntenis, Nikolaos and Schmucki, Roland and Hatje, Klas and Petermann, Olivier and Chiriano, Gianpaolo and Perozzo, Remo and Sciarra, Daniel and Konieczny, Piotr and Faustino, Ignacio and Fournet, Guy and Orozco, Modesto and Artero, Ruben and Metzger, Friedrich and Ebeling, Martin and Goekjian, Peter and Joseph, Benoît and Schwalbe, Harald and Scapozza, Leonardo

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes

Nature Communications (2018)

9,

10.1038/S41467-018-04110-1

Aymard, Chloé M. G. and Halma, Matilte and Comte, Arnaud and Mousty, Christine and Prévot, Vanessa and Hecquet, Laurence and Charmantray, Franck and Blum, Loïc J. and Doumèche, Bastien

Innovative Electrochemical Screening Allows Transketolase Inhibitors to Be Identified

Analytical Chemistry (2018)

90, 9241-9248

10.1021/ACS.ANALCHEM.8B01752

Altamura, Emiliano and Comte, Arnaud and D'Onofrio, Alice and Roussillon, Charlotte and Fayolle, Dimitri and Buchet, René and Mavelli, Fabio and Stano, Pasquale and Fiore, Michele and Strazewski, Peter

Racemic Phospholipids for Origin of Life Studies

Symmetry (2020)

12, 1108

10.3390/SYM12071108

Caputo, Alessia and Sartini, Sara and Levati, Elisabetta and Minato, Ilaria and Elisi, Gian Marco and Di Stasi, Adriana and Guillou, Catherine and Goekjian, Peter G. and Garcia, Pierre and Gueyrard, David and Bach, Stéphane and Comte, Arnaud and Ottonello, Simone and Rivara, Silvia and Montanini, Barbara

An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

Antibiotics (2022)

11, 1449

10.3390/ANTIBIOTICS11101449

Carrard, Julie and Ratajczak, Fiona and Elsens, Joséphine and Leroy, Catherine and Kong, Rebekah and Geoffroy, Lucie and Comte, Arnaud and Fournet, Guy and Joseph, Benoît and Li, Xiubin and Moebs-Sanchez, Sylvie and Lejeune, Fabrice

Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System

Biomedicines (2023)

11, 2801

10.3390/BIOMEDICINES11102801

Chieffo, Carolina and Comte, Arnaud and Strazewski, Peter and Fiore, Michele

Synthetic Outer Membrane Vesicles Bearing Tn Antigen

European Journal of Organic Chemistry (2023)

26,

10.1002/EJOC.202300820

Arhab, Yani and Bessaa, Karim and Abla, Houda and Aydin, Meryem and Rahier, Renaud and Comte, Arnaud and Brizuela, Leyre and Mebarek, Saïda and Perret, Florent and Cherrier, Mickaël V. and Abousalham, Abdelkarim and Noiriel, Alexandre

Phospholipase D inhibitors screening: Probing and evaluation of ancient and novel molecules

International Journal of Biological Macromolecules (2021)

166, 1131-1140

10.1016/J.IJBIOMAC.2020.10.268

Jabeur, Riheb and Corbel, Caroline and Loyer, Pascal and Le Parc, Annabelle and Le Grand, Adélaide and Comte, Arnaud and Bach, Stéphane and André-Leroux, Gwenaëlle and Sire, Olivier and Ben Mansour, Hedi and Le Tilly, Véronique

Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25

Biochemistry (2023)

62, 1452-1463

10.1021/ACS.BIOCHEM.2C00691

Georges, Rainier-Numa and Ballut, Lionel and Octobre, Guillaume and Comte, Arnaud and Hecquet, Laurence and Charmantray, Franck and Doumèche, Bastien

Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior

Protein Science (2024)

33,

10.1002/PRO.4884

Delehouzé, Claire and Comte, Arnaud and Leon-Icaza, Stephen Adonai and Cougoule, Céline and Hauteville, Marcelle and Goekjian, Peter and Bulinski, Jeannette Chloë and Dimanche-Boitrel, Marie-Thérèse and Meunier, Etienne and Rousselot, Morgane and Bach, Stéphane

Nigratine as dual inhibitor of necroptosis and ferroptosis regulated cell death

Scientific Reports (2022)

12,

10.1038/S41598-022-09019-W

Florès, Océane and Berthomé, Yann and Weiss, Lucille and Griesbaum-Dubourg, Sarah and Riché, Stéphanie and Wagner, Patrick and Valencia, Christel and Villa, Pascal and Klymchenko, Andrey S. and Karpenko, Julie and Bonnet, Dominique

Click-Functionalized Cyanine Fluorogenic Dimers for Improved Detection of GPCRs: Application to Imaging of ApelinR in Living Cells

Chemistry - A European Journal (2025)

31,

10.1002/CHEM.202500379

Vidal, François-Xavier and Gil, Julie and Gregson, Maud and Zeder-Lutz, Gabrielle and Hideux, Maria and Lemoine, Jérôme and Krimm, Isabelle and Wagner, Renaud and Dugas, Vincent and Demesmay, Claire

Development of ultra-miniaturized weak affinity chromatography coupled to mass spectrometry as a high throughput fragment screening method against wild-type and purified membrane proteins embedded in biomimetic membranes

Analytica Chimica Acta (2025)

1353, 343950

10.1016/J.ACA.2025.343950

Delaitre, Céline and Boisbrun, Michel and Acherar, Samir and Dias, André and Kleinclauss, Alexandra and Achard, Mathilde and Colin, Mélissa and Nguyen, Trung Minh and Humbert, Nicolas and Chmeis, Khawla and Martinez, Karen L. and Gilles, Nicolas and Robin, Philippe and Lecat, Sandra and Dupuis, François

Synthesis and Pharmacological Characterization of Fluorescent Ligands Targeting the Angiotensin II Receptors Derived from Agonists, ß-Arrestin-Biased Agonists, and Antagonists

Journal of Medicinal Chemistry (2024)

67, 20275-20297

10.1021/ACS.JMEDCHEM.4C01693

Maujean, Timothé and Ramanoudjame, Sridévi M. and Riché, Stéphanie and Le Guen, Clothilde and Boisson, Frédéric and Muller, Sylviane and Bonnet, Dominique and Gulea, Mihaela and Marchand, Patrice

Hetero-Diels-Alder and CuAAC Click Reactions for Fluorine-18 Labeling of Peptides: Automation and Comparative Study of the Two Methods

Molecules (2024)

29, 3198

10.3390/MOLECULES29133198

Berthomé, Yann and Gerber, Julie and Hanser, Fabien and Riché, Stéphanie and Humbert, Nicolas and Valencia, Christel and Villa, Pascal and Karpenko, Julie and Florès, Océane and Bonnet, Dominique

Rational Design of Cyanine-Based Fluorogenic Dimers to Reduce Nonspecific Interactions with Albumin and Lipid Bilayers: Application to Highly Sensitive Imaging of GPCRs in Living Cells

Bioconjugate Chemistry (2024)

35, 1182-1189

10.1021/ACS.BIOCONJCHEM.4C00147

Kintz, Pascal and Gheddar, Laurie and Garnier, Delphine

Evidence of ostarine excretion in oral fluid after a single controlled oral administration

Clinica Chimica Acta (2024)

557, 117879

10.1016/J.CCA.2024.117879

Mirloup, Antoine and Berthomé, Yann and Riché, Stéphanie and Wagner, Patrick and Hanser, Fabien and Laurent, Arthur and Iturrioz, Xavier and Llorens-Cortes, Catherine and Karpenko, Julie and Bonnet, Dominique

Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-Cell Imaging of Bioactive Peptides

Chemistry - A European Journal (2024)

30,

10.1002/CHEM.202401296

Djikic-Stojsic, Teodora and Bret, Guillaume and Blond, Gaëlle and Girard, Nicolas and Le Guen, Clothilde and Marsol, Claire and Schmitt, Martine and Schneider, Séverine and Bihel, Frederic and Bonnet, Dominique and Gulea, Mihaela and Kellenberger, Esther

The IMS Library: from IN-Stock to Virtual

ChemMedChem (2024)

19,

10.1002/CMDC.202400381

Vidal, François-Xavier and Deloche, Adrien and Zeder-Lutz, Gabrielle and Hideux, Maria and Wagner, Renaud and Dugas, Vincent and Demesmay, Claire

Ligand Screening of Membrane Proteins Embedded in Nanodiscs: How to Manage Non-Specific Interactions in Weak Affinity Chromatography?

Molecules (2024)

29, 2814

10.3390/MOLECULES29122814

Frossard, Nelly and Coïc, Alexandra and Saguet, Thibaut and Coïc, Alain and Himbert, Franck and Do, Quoc Tuan and Galzi, Jean-Luc and Suehs, Carey and Guillaumet, Gerald and Bonnet, Pascal and Bernard, Philippe

Randomized double-blind placebo-controlled cosmetic trial of a topical first-in-class Neutraligand targeting the chemokine TARC/CCL17 in mild-to-moderate atopic dermatitis

International Journal of Cosmetic Science (2024)

46, 468-477

10.1111/ICS.12948

Kuntzel, Thomas and Spenlé, Caroline and Pham-Van, Lucas and Birmpili, Dafni and Riou, Aurélien and Loeuillet, Aurore and Charmarke-Askar, Imane and Bagnard, Dominique

Implication of the Transmembrane Domain in the Interleukin 10 Receptor Platform Oligomerisation

Cells (2023)

12, 1361

10.3390/CELLS12101361

Foisset, F. and Lehalle, C. and Nasri, A. and Bourdais, C. and Morichon, L. and Petit, A. and Vachier, I. and Assou, S. and Bourdin, A. and Frossard, N. and De Vos, J.

Fabrication d'un épithélium bronchique innervé à partir d'une prise de sang

Revue des Maladies Respiratoires (2023)

40, 247-249

10.1016/J.RMR.2023.01.021

Zeder-Lutz, Gabrielle and Bornert, Olivier and Fellmann-Clauss, Rosine and Knittel-Obrecht, Adeline and Tranchant, Thibaud and Bouteben, Sarah and Kaeffer, Juliette and Quillet, Raphaëlle and Villa, Pascal and Wagner, Renaud and Lecat, Sandra and Simonin, Frédéric

Characterization of anti-GASP motif antibodies that inhibit the interaction between GPRASP1 and G protein-coupled receptors

Analytical Biochemistry (2023)

665, 115062

10.1016/J.AB.2023.115062

Maujean, Timothé and Wagner, Patrick and Valencia, Christel and Riché, Stéphanie and Iturrioz, Xavier and Villa, Pascal and Girard, Nicolas and Karpenko, Julie and Gulea, Mihaela and Bonnet, Dominique

Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin

Bioconjugate Chemistry (2023)

34, 162-168

10.1021/ACS.BIOCONJCHEM.2C00500

Eguida, Merveille and Schmitt-Valencia, Christel and Hibert, Marcel and Villa, Pascal and Rognan, Didier

Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking

Journal of Medicinal Chemistry (2022)

65, 13771-13783

10.1021/ACS.JMEDCHEM.2C00931

Pierrevelcin, Marina and Flacher, Vincent and Mueller, Christopher G. and Vauchelles, Romain and Guerin, Eric and Lhermitte, Benoît and Pencreach, Erwan and Reisch, Andreas and Muller, Quentin and Doumard, Layal and Boufenghour, Wacym and Klymchenko, Andrey S. and Foppolo, Sophie and Nazon, Charlotte and Weingertner, Noelle and Martin, Sophie and Briandet, Claire and Laithier, Véronique and Di Marco, Antonio and Bund, Laurent and Obrecht, Adeline and Villa, Pascal and Dontenwill, Monique and Entz-Werlé, Natacha

Engineering Novel 3D Models to Recreate High-Grade Osteosarcoma and its Immune and Extracellular Matrix Microenvironment

Advanced Healthcare Materials (2022)

11,

10.1002/ADHM.202200195

Hany, Romain and Leyris, Jean-Philippe and Bret, Guillaume and Mallié, Sylvie and Sar, Chamroeun and Thouaye, Maxime and Hamze, Abdallah and Provot, Olivier and Sokoloff, Pierre and Valmier, Jean and Villa, Pascal and Rognan, Didier

High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators

ACS Chemical Biology (2022)

17, 709-722

10.1021/ACSCHEMBIO.2C00048

Poirot, Anh and Wacht, Guillaume and Lehalle, Christine and Saas, Philippe and Frossard, Nelly and Geny, Bernard and de Blay, Fréderic and Barnig, Cindy

NK cells and lipoxin A4 promote resolution of eosinophilic inflammation after nasal allergen challenge

Allergy (2022)

77, 309-313

10.1111/ALL.15103

Houël, Emeline and Ginouves, Marine and Azas, Nadine and Bourreau, Eliane and Eparvier, Véronique and Hutter, Sébastien and Knittel-Obrecht, Adeline and Jahn-Oyac, Arnaud and Prévot, Ghislaine and Villa, Pascal and Vonthron-Sénécheau, Catherine and Odonne, Guillaume

Treating leishmaniasis in Amazonia, part 2: Multi-target evaluation of widely used plants to understand medicinal practices

Journal of Ethnopharmacology (2022)

289, 115054

10.1016/J.JEP.2022.115054

Megat, Salim and Hugel, Sylvain and Journée, Sarah H. and Bohren, Yohann and Lacaud, Adrien and Lelièvre, Vincent and Doridot, Stéphane and Villa, Pascal and Bourguignon, Jean-Jacques and Salvat, Eric and Schlichter, Remy and Freund-Mercier, Marie-José and Yalcin, Ipek and Barrot, Michel

Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury

Neuropharmacology (2022)

205, 108909

10.1016/J.NEUROPHARM.2021.108909

Hanser, Fabien and Marsol, Claire and Valencia, Christel and Villa, Pascal and Klymchenko, Andrey S. and Bonnet, Dominique and Karpenko, Julie

Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor

ACS Chemical Biology (2021)

16, 651-660

10.1021/ACSCHEMBIO.0C00897

Demay, Justine and Halary, Sébastien and Knittel-Obrecht, Adeline and Villa, Pascal and Duval, Charlotte and Hamlaoui, Sahima and Roussel, Théotime and Yéprémian, Claude and Reinhardt, Anita and Bernard, Cécile and Marie, Benjamin

Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study

Biomolecules (2020)

11, 28

10.3390/BIOM11010028

Bollenbach, Maud and Nemska, Simona and Wagner, Patrick and Camelin, Guillaume and Daubeuf, François and Obrecht, Adeline and Villa, Pascal and Rognan, Didier and Bihel, Frédéric and Bourguignon, Jean-Jacques and Schmitt, Martine and Frossard, Nelly

Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model

Molecules (2021)

26, 391

10.3390/MOLECULES26020391

Nemska, Simona and Daubeuf, François and Obrecht, Adeline and Israel-Biet, Dominique and Stern, Marc and Kessler, Romain and Roux, Antoine and Tavakoli, Reza and Villa, Pascal and Tissot, Adrien and Danger, Richard and Reber, Laurent and Durand, Eugénie and Foureau, Aurore and Brouard, Sophie and Magnan, Antoine and Frossard, Nelly

Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model

Transplantation (2021)

105, 1212-1224

10.1097/TP.0000000000003606

Eydoux, Cecilia and Fattorini, Veronique and Shannon, Ashleigh and Le, Thi-Tuyet-Nhung and Didier, Bruno and Canard, Bruno and Guillemot, Jean-Claude

A fluorescence-based high throughput-screening assay for the SARS-CoV RNA synthesis complex

Journal of Virological Methods (2021)

288, 114013

10.1016/J.JVIROMET.2020.114013

Calas, André-Guilhem and Hanak, Anne-Sophie and Jaffré, Nina and Nervo, Aurélie and Dias, José and Rousseau, Catherine and Courageux, Charlotte and Brazzolotto, Xavier and Villa, Pascal and Obrecht, Adeline and Goossens, Jean-François and Landry, Christophe and Hachani, Johan and Gosselet, Fabien and Dehouck, Marie-Pierre and Yerri, Jagadeesh and Kliachyna, Maria and Baati, Rachid and Nachon, Florian

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules (2020)

10, 858

10.3390/BIOM10060858

Bordenave, Jennifer and Thuillet, Raphaël and Tu, Ly and Phan, Carole and Cumont, Amélie and Marsol, Claire and Huertas, Alice and Savale, Laurent and Hibert, Marcel and Galzi, Jean-Luc and Bonnet, Dominique and Humbert, Marc and Frossard, Nelly and Guignabert, Christophe

Neutralization of CXCL12 attenuates established pulmonary hypertension in rats

Cardiovascular Research (2020)

116, 686-697

10.1093/CVR/CVZ153

Blandin, Anne-Florence and Durand, Aurélie and Litzler, Marie and Tripp, Aurélien and Guérin, Éric and Ruhland, Elisa and Obrecht, Adeline and Keime, Céline and Fuchs, Quentin and Reita, Damien and Lhermitte, Benoit and Coca, Andres and Jones, Chris and Rebel, Isabelle Lelong and Villa, Pascal and Namer, Izzie Jacques and Dontenwill, Monique and Guenot, Dominique and Entz-Werle, Natacha

Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric H3.3-Mutated Gliomas Recreate the Patient Tumor Complexity

Cancers (2019)

11, 1875

10.3390/CANCERS11121875

Bouressam, Marie-Lynda and Lecat, Sandra and Raoul, Alexandre and Gaucher, Caroline and Perrin-Sarrado, Caroline and Lartaud, Isabelle and Dupuis, François

S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses: A possible role of S-nitrosation

British Journal of Pharmacology (2019)

176, 2049-2062

10.1111/BPH.14644

Regenass, Pierre and Abboud, Dayana and Daubeuf, François and Lehalle, Christine and Gizzi, Patrick and Riché, Stéphanie and Hachet-Haas, Muriel and Rohmer, François and Gasparik, Vincent and Boeglin, Damien and Haiech, Jacques and Knehans, Tim and Rognan, Didier and Heissler, Denis and Marsol, Claire and Villa, Pascal and Galzi, Jean-Luc and Hibert, Marcel and Frossard, Nelly and Bonnet, Dominique

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

Journal of Medicinal Chemistry (2018)

61, 7671-7686

10.1021/ACS.JMEDCHEM.8B00657

Aviolat, Hubert and Nominé, Yves and Gioria, Sophie and Bonhoure, Anna and Hoffmann, David and Ruhlmann, Christine and Nierengarten, Hélène and Ruffenach, Frank and Villa, Pascal and Trottier, Yvon and Klein, Fabrice A.C.

SynAggreg: A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds

Journal of Molecular Biology (2018)

430, 5257-5279

10.1016/J.JMB.2018.09.009

Frantz, Marie-Céline and Pellissier, Lucie P. and Pflimlin, Elsa and Loison, Stéphanie and Gandía, Jorge and Marsol, Claire and Durroux, Thierry and Mouillac, Bernard and Becker, Jérôme A. J. and Le Merrer, Julie and Valencia, Christel and Villa, Pascal and Bonnet, Dominique and Hibert, Marcel

LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism

Journal of Medicinal Chemistry (2018)

61, 8670-8692

10.1021/ACS.JMEDCHEM.8B00697

Chen, Wanyin and Zebaze, Leonel Nguekeu and Dong, Jihu and Chézeau, Laëtitia and Inquimbert, Perrine and Hugel, Sylvain and Niu, Songlin and Bihel, Fréderic and Boutant, Emmanuel and Réal, Eléonore and Villa, Pascal and Junier, Marie-Pierre and Chneiweiss, Hervé and Hibert, Marcel and Haiech, Jacques and Kilhoffer, Marie-Claude and Zeniou, Maria

WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling

Oncotarget (2018)

9, 27197-27219

10.18632/ONCOTARGET.25509

Hammoud, Hassan and Elhabazi, Khadija and Quillet, Raphäelle and Bertin, Isabelle and Utard, Valérie and Laboureyras, Emilie and Bourguignon, Jean-Jacques and Bihel, Frédéric and Simonnet, Guy and Simonin, Frédéric and Schmitt, Martine

Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia

ACS Chemical Neuroscience (2018)

9, 2599-2609

10.1021/ACSCHEMNEURO.8B00099

Bollenbach, Maud and Salvat, Eric and Daubeuf, François and Wagner, Patrick and Yalcin, Ipek and Humo, Muris and Letellier, Baptiste and Becker, Léa J. and Bihel, Frédéric and Bourguignon, Jean-Jacques and Villa, Pascal and Obrecht, Adeline and Frossard, Nelly and Barrot, Michel and Schmitt, Martine

Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFalpha overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation

European Journal of Medicinal Chemistry (2018)

147, 163-182

10.1016/J.EJMECH.2018.01.049

Chakraborty, M. and Sellier, Chantal and Ney, Michel and Villa, Pascal and Charlet-Berguerand, Nicolas and Artero, R. and Llamusi, B.

Daunorubicin reduces MBNL1 titration by expanded CUG repeat RNA and rescues cardiac dysfunctions in a Drosophila model of myotonic dystrophy

Disease Models & Mechanisms (2018)

,

10.1242/DMM.032557

Aulestia, Francisco J. and Néant, Isabelle and Dong, Jihu and Haiech, Jacques and Kilhoffer, Marie-Claude and Moreau, Marc and Leclerc, Catherine

Quiescence status of glioblastoma stem-like cells involves remodelling of Ca2+ signalling and mitochondrial shape

Scientific Reports (2018)

8,

10.1038/S41598-018-28157-8

Bouressam, Marie-Lynda and Lartaud, Isabelle and Dupuis, François and Lecat, Sandra

No answer to the lack of specificity: mouse monoclonal antibody targeting the angiotensin II type 1 receptor AT1 fails to recognize its target

Naunyn-Schmiedeberg's Archives of Pharmacology (2018)

391, 883-889

10.1007/S00210-018-1522-4

Soleilhac, Emmanuelle and Brillet-Guéguen, Loraine and Roussel, Véronique and Prudent, Renaud and Touquet, Bastien and Dass, Sheena and Aci-Sèche, Samia and Kasam, Vinod and Barette, Caroline and Imberty, Anne and Breton, Vincent and Vantard, Marylin and Horvath, Dragos and Botté, Cyrille and Tardieux, Isabelle and Roy, Sylvaine and Maréchal, Eric and Lafanechère, Laurence

Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches

International Journal of Molecular Sciences (2018)

19, 3085

10.3390/IJMS19103085

Conte, Melissa and Lupette, Josselin and Seddiki, Khawla and Meï, Coline and Dolch, Lina-Juana and Gros, Valérie and Barette, Caroline and Rébeillé, Fabrice and Jouhet, Juliette and Maréchal, Eric

Screening for Biologically Annotated Drugs That Trigger Triacylglycerol Accumulation in the Diatom Phaeodactylum

Plant Physiology (2018)

177, 532-552

10.1104/PP.17.01804

Cortes, Sandra and Barette, Caroline and Beroud, Rémy and De Waard, Michel and Schaack, Béatrice

Functional characterization of cell-free expressed Kv1.3 channel using a voltage-sensitive fluorescent dye

Protein Expression and Purification (2018)

145, 94-99

10.1016/J.PEP.2018.01.006

Ouarné, Marie and Bouvard, Claire and Boneva, Gabriela and Mallet, Christine and Ribeiro, Johnny and Desroches-Castan, Agnès and Soleilhac, Emmanuelle and Tillet, Emmanuelle and Peyruchaud, Olivier and Bailly, Sabine

BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer

Journal of Experimental & Clinical Cancer Research (2018)

37,

10.1186/S13046-018-0885-1

Wallez, Yann and Bouillot, Stéphanie and Soleilhac, Emmanuelle and Huber, Philippe and Attrée, Ina and Faudry, Eric

CLIQ-BID: A method to quantify bacteria-induced damage to eukaryotic cells by automated live-imaging of bright nuclei

Scientific Reports (2018)

8,

10.1038/S41598-017-18501-9

Crespo-Yàñez, Xènia and Aguilar-Gurrieri, Carmen and Jacomin, Anne-Claire and Journet, Agnès and Mortier, Magda and Taillebourg, Emmanuel and Soleilhac, Emmanuelle and Weissenhorn, Winfried and Fauvarque, Marie-Odile

CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis

PLOS Genetics (2018)

14, e1007456

10.1371/JOURNAL.PGEN.1007456

Ngo, Tuan-Dung and Plé, Sophie and Thomas, Aline and Barette, Caroline and Fortuné, Antoine and Bouzidi, Younes and Fauvarque, Marie-Odile and Pereira de Freitas, Rossimiriam and Francisco Hilário, Flaviane and Attrée, Ina and Wong, Yung-Sing and Faudry, Eric

Chimeric Protein-Protein Interface Inhibitors Allow Efficient Inhibition of Type III Secretion Machinery and Pseudomonas aeruginosa Virulence

ACS Infectious Diseases (2019)

5, 1843-1854

10.1021/ACSINFECDIS.9B00154

Picoli, Christèle and Soleilhac, Emmanuelle and Journet, Agnès and Barette, Caroline and Comte, Marjorie and Giaume, Christian and Mouthon, Franck and Fauvarque, Marie-Odile and Charvériat, Mathieu

High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions

ASSAY and Drug Development Technologies (2019)

17, 240-248

10.1089/ADT.2019.927

Ramirez-Rios, Sacnicte and Michallet, Sophie and Peris, Leticia and Barette, Caroline and Rabat, Clotilde and Feng, Yangbo and Fauvarque, Marie-Odile and Andrieux, Annie and Sadoul, Karin and Lafanechère, Laurence

A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Frontiers in Pharmacology (2020)

11,

10.3389/FPHAR.2020.00543

Senarisoy, Muge and Barette, Caroline and Lacroix, Françoise and De Bonis, Salvatore and Stelter, Meike and Hans, Fabienne and Kleman, Jean-Philippe and Fauvarque, Marie-Odile and Timmins, Joanna

Förster Resonance Energy Transfer Based Biosensor for Targeting the hNTH1-YB1 Interface as a Potential Anticancer Drug Target

ACS Chemical Biology (2020)

15, 990-1003

10.1021/ACSCHEMBIO.9B01023

Faouzi, Abdelfattah and Arnaud, Alexandre and Bancet, Alexandre and Barette, Caroline and Preto, Jordane and Do, Cong Viet and Jordheim, Lars Petter and Bousfiha, Zineb and Nguyen, Thi Thanh Binh and Verrière, Marion and Farce, Amaury and Fauvarque, Marie-Odile and Barret, Roland and Lomberget, Thierry

Combretastatin A-4 sulfur-containing heterocyclic derivatives: Synthesis, antiproliferative activities and molecular docking studies

European Journal of Medicinal Chemistry (2021)

215, 113275

10.1016/J.EJMECH.2021.113275

Giacosa, Sofia and Pillet, Catherine and Séraudie, Irinka and Guyon, Laurent and Wallez, Yann and Roelants, Caroline and Battail, Christophe and Evrard, Bertrand and Chalmel, Frédéric and Barette, Caroline and Soleilhac, Emmanuelle and Fauvarque, Marie-Odile and Franquet, Quentin and Sarrazin, Clément and Peilleron, Nicolas and Fiard, Gaëlle and Long, Jean-Alexandre and Descotes, Jean-Luc and Cochet, Claude and Filhol, Odile

Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction

Cancers (2021)

13, 576

10.3390/CANCERS13030576

Kobaisi, Farah and Sulpice, Eric and Barette, Caroline and Fayyad, Nour and Fauvarque, Marie-Odile and Badran, Bassam and Fayyad-Kazan, Mohammad and Fayyad-Kazan, Hussein and Gidrol, Xavier and Rachidi, Walid

Isoconazole and Clemizole Hydrochloride Partially Reverse the Xeroderma Pigmentosum C Phenotype

International Journal of Molecular Sciences (2021)

22, 8156

10.3390/IJMS22158156

Rioux, Benjamin and Pinon, Aline and Gamond, Aurélie and Martin, Frédérique and Laurent, Aurélie and Champavier, Yves and Barette, Caroline and Liagre, Bertrand and Fagnère, Catherine and Sol, Vincent and Pouget, Christelle

Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy

European Journal of Medicinal Chemistry (2021)

222, 113586

10.1016/J.EJMECH.2021.113586

Soleilhac, Emmanuelle and Comte, Marjorie and da Costa, Anaelle and Barette, Caroline and Picoli, Christèle and Mortier, Magda and Aubry, Laurence and Mouthon, Franck and Fauvarque, Marie-Odile and Charvériat, Mathieu

Quantitative Automated Assays in Living Cells to Screen for Inhibitors of Hemichannel Function

SLAS Discovery (2021)

26, 420-427

10.1177/2472555220954388

Journet, Agnès and Barette, Caroline and Aubry, Laurence and Soleilhac, Emmanuelle and Fauvarque, Marie-Odile

Identification of chemicals breaking the USP8 interaction with its endocytic substrate CHMP1B

SLAS Discovery (2022)

27, 395-404

10.1016/J.SLASD.2022.08.003

Mameri, Hamza and Buhagiar-Labarchède, Géraldine and Fontaine, Gaëlle and Corcelle, Céline and Barette, Caroline and Onclercq-Delic, Rosine and Beauvineau, Claire and Mahuteau-Betzer, Florence and Amor-Guéret, Mounira

Cytidine deaminase deficiency in tumor cells is associated with sensitivity to a naphthol derivative and a decrease in oncometabolite levels

Cellular and Molecular Life Sciences (2022)

79,

10.1007/S00018-022-04487-9

Saier, Lou and Ribeiro, Johnny and Daunizeau, Thomas and Houssin, Audrey and Ichim, Gabriel and Barette, Caroline and Bouazza, Lamia and Peyruchaud, Olivier

Blockade of Platelet CysLT1R Receptor with Zafirlukast Counteracts Platelet Protumoral Action and Prevents Breast Cancer Metastasis to Bone and Lung

International Journal of Molecular Sciences (2022)

23, 12221

10.3390/IJMS232012221

Gori, Anthonin and Boucherle, Benjamin and Rey, Aurélien and Rome, Maxime and Barette, Caroline and Soleilhac, Emmanuelle and Philouze, Christian and Fauvarque, Marie-Odile and Fuzzati, Nicola and Peuchmaur, Marine

Investigation of Chemical Composition and Biological Activities of Ajuga pyramidalis-Isolation of Iridoids and Phenylethanoid Glycosides

Metabolites (2023)

13, 128

10.3390/METABO13010128

Reynaud, Déborah and Alfaidy, Nadia and Collet, Constance and Lemaitre, Nicolas and Sergent, Frederic and Miege, Céline and Soleilhac, Emmanuelle and Assi, Alaa Al and Murthi, Padma and Courtois, Gilles and Fauvarque, Marie-Odile and Slim, Rima and Benharouga, Mohamed and Abi Nahed, Roland

NLRP7 Enhances Choriocarcinoma Cell Survival and Camouflage in an Inflammasome Independent Pathway

Cells (2023)

12, 857

10.3390/CELLS12060857

Robin, Adeline Y and Brochier-Armanet, Céline and Bertrand, Quentin and Barette, Caroline and Girard, Eric and Madern, Dominique

Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery

Molecular Biology and Evolution (2023)

40,

10.1093/MOLBEV/MSAD223

Hoffer, Laurent and Voitovich, Yuliia V. and Raux, Brigitt and Carrasco, Kendall and Muller, Christophe and Fedorov, Aleksey Y. and Derviaux, Carine and Amouric, Agnès and Betzi, Stéphane and Horvath, Dragos and Varnek, Alexandre and Collette, Yves and Combes, Sébastien and Roche, Philippe and Morelli, Xavier

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach

Journal of Medicinal Chemistry (2018)

61, 5719-5732

10.1021/ACS.JMEDCHEM.8B00653

Taïeb, David and Jha, Abhishek and Guerin, Carole and Pang, Ying and Adams, Karen T and Chen, Clara C and Romanet, Pauline and Roche, Philippe and Essamet, Wassim and Ling, Alexander and Quezado, Martha M and Castinetti, Frédéric and Sebag, Fréderic and Pacak, Karel

18F-FDOPA PET/CT Imaging of MAX-Related Pheochromocytoma

The Journal of Clinical Endocrinology & Metabolism (2018)

103, 1574-1582

10.1210/JC.2017-02324

de Groot, Arjan and Siponen, Marina I and Magerand, Romaric and Eugénie, Nicolas and Martin-Arevalillo, Raquel and Doloy, Jade and Lemaire, David and Brandelet, Géraldine and Parcy, François and Dumas, Renaud and Roche, Philippe and Servant, Pascale and Confalonieri, Fabrice and Arnoux, Pascal and Pignol, David and Blanchard, Laurence

Crystal structure of the transcriptional repressor DdrO: insight into the metalloprotease/repressor-controlled radiation response in Deinococcus

Nucleic Acids Research (2019)

47, 11403-11417

10.1093/NAR/GKZ883

Guiseppi, Annick and Vicente, Juan Jesus and Herrou, Julien and Byrne, Deborah and Barneoud, Aurelie and Moine, Audrey and Espinosa, Leon and Basse, Marie-Jeanne and Molle, Virginie and Mignot, Tâm and Roche, Philippe and Mauriello, Emilia M. F.

A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays

PLOS Genetics (2019)

15, e1008533

10.1371/JOURNAL.PGEN.1008533

Hernandez, Jessica and Hoffer, Laurent and Coutard, Bruno and Querat, Gilles and Roche, Philippe and Morelli, Xavier and Decroly, Etienne and Barral, Karine

Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

European Journal of Medicinal Chemistry (2019)

161, 323-333

10.1016/J.EJMECH.2018.09.056

Hoffer, Laurent and Saez-Ayala, Magali and Horvath, Dragos and Varnek, Alexandre and Morelli, Xavier and Roche, Philippe

CovaDOTS: In Silico Chemistry-Driven Tool to Design Covalent Inhibitors Using a Linking Strategy

Journal of Chemical Information and Modeling (2019)

59, 1472-1485

10.1021/ACS.JCIM.8B00960

Bosc, Nicolas and Muller, Christophe and Hoffer, Laurent and Lagorce, David and Bourg, Stéphane and Derviaux, Carine and Gourdel, Marie-Edith and Rain, Jean-Christophe and Miller, Thomas W. and Villoutreix, Bruno O. and Miteva, Maria A. and Bonnet, Pascal and Morelli, Xavier and Sperandio, Olivier and Roche, Philippe

Fr-PPIChem: An Academic Compound Library Dedicated to Protein-Protein Interactions

ACS Chemical Biology (2020)

15, 1566-1574

10.1021/ACSCHEMBIO.0C00179

Ganier, Laetitia and Morelli, Xavier and Borg, Jean-Paul

Rôle en cancérologie et ciblage du récepteur à activité tyrosine kinase PTK7

médecine/sciences (2020)

36, 42-46

10.1051/MEDSCI/2020197

Leblanc, R. and Kashyap, R. and Barral, K. and Egea-Jimenez, A.L. and Kovalskyy, D. and Feracci, M. and Garcia, M. and Derviaux, C. and Betzi, S. and Ghossoub, R. and Platonov, M. and Roche, P. and Morelli, X. and Hoffer, L. and Zimmermann, Pascale

Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

Journal of Extracellular Vesicles (2020)

10,

10.1002/JEV2.12039

Garcia, Manon and Hoffer, Laurent and Leblanc, Raphaël and Benmansour, Fatiha and Feracci, Mikael and Derviaux, Carine and Egea-Jimenez, Antonio Luis and Roche, Philippe and Zimmermann, Pascale and Morelli, Xavier and Barral, Karine

Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread

European Journal of Medicinal Chemistry (2021)

223, 113601

10.1016/J.EJMECH.2021.113601

Chantal Lagresle-Peyrou and Aurélien Olichon and Hanem Sadek and Philippe Roche and Claudine Tardy and Cindy Da Silva and Alexandrine Garrigue and Alain Fischer and Despina Moshous and Yves Collette and Capucine Picard and Jean Laurent Casanova and Isabelle André and Marina Cavazzana

A gain-of-function RAC2 mutation is associated with bone-marrow hypoplasia and an autosomal dominant form of severe combined immunodeficiency

Haematologica (2020)

106, 404-411

10.3324/HAEMATOL.2019.230250

Ganier, Laetitia and Betzi, Stephane and Derviaux, Carine and Roche, Philippe and Dessaux, Charlotte and Muller, Christophe and Hoffer, Laurent and Morelli, Xavier and Borg, Jean-Paul

Discovery of Small-Molecule Inhibitors of the PTK7/ß-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer

ACS Chemical Biology (2022)

17, 1061-1072

10.1021/ACSCHEMBIO.1C00826

Saez-Ayala, Magali and Hoffer, Laurent and Abel, Sébastien and Ben Yaala, Khaoula and Sicard, Benoit and Andrieu, Guillaume P. and Latiri, Mehdi and Davison, Emma K. and Ciufolini, Marco A. and Brémond, Paul and Rebuffet, Etienne and Roche, Philippe and Derviaux, Carine and Voisset, Edwige and Montersino, Camille and Castellano, Remy and Collette, Yves and Asnafi, Vahid and Betzi, Stéphane and Dubreuil, Patrice and Combes, Sébastien and Morelli, Xavier

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia

Nature Communications (2023)

14,

10.1038/S41467-023-38668-2

Carrasco, Kendall and Montersino, Camille and Derviaux, Carine and Saez-Ayala, Magali and Hoffer, Laurent and Restouin, Audrey and Castellano, Rémy and Casassa, Justine and Roche, Philippe and Pasquier, Eddy and Combes, Sébastien and Morelli, Xavier and Collette, Yves and Betzi, Stéphane

CRCM5484: A BET-BDII Selective Compound with Differential Anti-leukemic Drug Modulation

Journal of Medicinal Chemistry (2022)

65, 5660-5674

10.1021/ACS.JMEDCHEM.1C02168

Hoffer, Laurent and Garcia, Manon and Leblanc, Raphael and Feracci, Mikael and Betzi, Stéphane and Ben Yaala, Khaoula and Daulat, Avais M. and Zimmermann, Pascale and Roche, Philippe and Barral, Karine and Morelli, Xavier

Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach

Journal of Medicinal Chemistry (2023)

66, 4633-4658

10.1021/ACS.JMEDCHEM.2C01569

Cuny, Thomas and Romanet, Pauline and Goldsworthy, Michelle and Guérin, Carole and Wilkin, Marie and Roche, Philippe and Sebag, Frédéric and van Summeren, Lynn E and Stevenson, Mark and Howles, Sarah A and Deharo, Jean-Claude and Thakker, Rajesh V and Taïeb, David

Cinacalcet Reverses Short QT Interval in Familial Hypocalciuric Hypercalcemia Type 1

The Journal of Clinical Endocrinology & Metabolism (2024)

109, 549-556

10.1210/CLINEM/DGAD494

Desaunay, Mathieu and Voisset, Edwige and Letard, Sebastien and Roche, Philippe and De Sepulveda, Paulo

The Recurrent Liver MAN2A1-FER Oncoprotein Lacks Kinase Activity: Implications for the Use of Tyrosine Kinase Inhibitors

Cellular and Molecular Gastroenterology and Hepatology (2024)

17, 667-669

10.1016/J.JCMGH.2023.12.007

Hoffer, Laurent and Charifi-Hoareau, Guillaume and Barelier, Sarah and Betzi, Stéphane and Miller, Thomas and Morelli, Xavier and Roche, Philippe

ChemoDOTS: a web server to design chemistry-driven focused libraries

Nucleic Acids Research (2024)

52, W461-W468

10.1093/NAR/GKAE326

Douguet, Dominique

Data Sets Representative of the Structures and Experimental Properties of FDA-Approved Drugs

ACS Medicinal Chemistry Letters (2018)

9, 204-209

10.1021/ACSMEDCHEMLETT.7B00462

Signetti, Laurie and Elizarov, Nelli and Simsir, Méliné and Paquet, Agnès and Douguet, Dominique and Labbal, Fabien and Debayle, Delphine and Di Giorgio, Audrey and Biou, Valérie and Girard, Christophe and Duca, Maria and Bretillon, Lionel and Bertolotto, Corine and Verrier, Bernard and Azoulay, Stéphane and Mus-Veteau, Isabelle

Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma

Cancers (2020)

12, 1500

10.3390/CANCERS12061500

Douguet, Dominique and Payan, Frédéric

sensaas: Shape-based Alignment by Registration of Colored Point-based Surfaces

Molecular Informatics (2020)

39,

10.1002/MINF.202000081

Biyuzan, Hamza and Masrour, Mohamed-Akram and Grandmougin, Lucas and Payan, Frédéric and Douguet, Dominique

SENSAAS-Flex: a joint optimization approach for aligning 3D shapes and exploring the molecular conformation space

Bioinformatics (2024)

40,

10.1093/BIOINFORMATICS/BTAE105

Ameri, Rihab and Laville, Elisabeth and Potocki-Véronèse, Gabrielle and Trabelsi, Sahar and Mezghani, Monia and Elgharbi, Fatma and Bejar, Samir

Two new gene clusters involved in the degradation of plant cell wall from the fecal microbiota of Tunisian dromedary

PLOS ONE (2018)

13, e0194621

10.1371/JOURNAL.PONE.0194621

Bourkhis, Maroua and Gaspard, Hafida and Rullière, Pauline and de Almeida, Diana K. C. and Listunov, Dymytrii and Joly, Etienne and Abderrahim, Raoudha and de Mattos, Marcos C. and de Oliveira, Maria C. F. and Maraval, Valérie and Chauvin, Remi and Génisson, Yves

Skeletal Optimization of Cytotoxic Lipidic Dialkynylcarbinols

ChemMedChem (2018)

13, 1124-1130

10.1002/CMDC.201800118

Chollet, Aurélien and Maveyraud, Laurent and Lherbet, Christian and Bernardes-Génisson, Vania

An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors

European Journal of Medicinal Chemistry (2018)

146, 318-343

10.1016/J.EJMECH.2018.01.047

Faucard, Pauline and Grimaud, Florent and Lourdin, Denis and Maigret, Jean-Eudes and Moulis, Claire and Remaud-Siméon, Magali and Putaux, Jean-Luc and Potocki-Véronèse, Gabrielle and Rolland-Sabaté, Agnès

Macromolecular structure and film properties of enzymatically-engineered high molar mass dextrans

Carbohydrate Polymers (2018)

181, 337-344

10.1016/J.CARBPOL.2017.10.065

Gervais, Virginie and Muller, Isabelle and Mari, Pierre-Olivier and Mourcet, Amandine and Movellan, Kumar Tekwani and Ramos, Pascal and Marcoux, Julien and Guillet, Valérie and Javaid, Sumaira and Burlet-Schiltz, Odile and Czaplicki, Georges and Milon, Alain and Giglia-Mari, Giuseppina

Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy

Journal of Biological Chemistry (2018)

293, 14974-14988

10.1074/JBC.RA118.003444

Grimaud, F. and Faucard, P. and Tarquis, L. and Pizzut-Serin, S. and Roblin, P. and Morel, S. and Le Gall, S. and Falourd, X. and Rolland-Sabaté, A. and Lourdin, D. and Moulis, C. and Remaud-Siméon, M. and Potocki-Veronese, G.

Enzymatic synthesis of polysaccharide-based copolymers

Green Chemistry (2018)

20, 4012-4022

10.1039/C8GC01251B

Irague, Romain and Topham, Christopher M. and Martineau, Nelly and Baylac, Audrey and Auriol, Clément and Walther, Thomas and François, Jean-Marie and André, Isabelle and Remaud-Siméon, Magali

A generic HTS assay for kinase screening: Validation for the isolation of an engineered malate kinase

PLOS ONE (2018)

13, e0193036

10.1371/JOURNAL.PONE.0193036

Chaibi, Fatima-Zahra and Brier, Lucile and Carré, Paul and Landry, Valérie and Desmarets, Lowiese and Tarricone, Audrey and Cantrelle, François-Xavier and Moschidi, Danai and Herledan, Adrien and Biela, Alexandre and Bourgeois, Fanny and Ribes, Chloé and Ikherbane, Sarah and Malessan, Mathilde and Dubuisson, Jean and Belouzard, Sandrine and Hanoulle, Xavier and Leroux, Florence and Deprez, Benoit and Charton, Julie

N-acylbenzimidazoles as selective Acylators of the catalytic cystein of the coronavirus 3CL protease

European Journal of Medicinal Chemistry (2024)

276, 116707

10.1016/J.EJMECH.2024.116707

Ruggieri, Francesca and Hance, Philippe and Gioia, Bruna and Biela, Alexandre and Roussel, Pascal and Hilbert, Jean-Louis and Willand, Nicolas

A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards

Pharmaceuticals (2023)

16, 771

10.3390/PH16050771

Ruggieri, Francesca and Compagne, Nina and Antraygues, Kevin and Eveque, Maxime and Flipo, Marion and Willand, Nicolas

Antibiotics with novel mode of action as new weapons to fight antimicrobial resistance

European Journal of Medicinal Chemistry (2023)

256, 115413

10.1016/J.EJMECH.2023.115413

Antraygues, Kevin and Compagne, Nina and Ruggieri, Francesca and Djaout, Kamel and Edoo, Zainab and Eveque, Maxime and Faïon, Léo and Gioia, Bruna and Tangara, Salia and Vieira Da Cruz, Anais and Villemagne, Baptiste and Flipo, Marion and Baulard, Alain and Willand, Nicolas

On the Hunt for Next-Generation Antimicrobial Agents: An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Société de Chimie Thérapeutique) and the French Microbiology Society on 9-10 December 2021

Pharmaceuticals (2022)

15, 388

10.3390/PH15040388

Songue Same, Oliver and Biela, Alexandre and Piveteau, Catherine and Kamga, Richard and Deprez, Benoit

Exposure to Bisphenols from Baby Bottles and Non-Food Containers Used for Food Preservation in Cameroon

SSRN Electronic Journal (2023)

,

10.2139/SSRN.4202206

Songue Same, Oliver and Piveteau, Catherine and Biela, Alexandre and Kamga, Richard and Deprez, Benoit

Exposure to Bisphenols from Baby Bottles and Non-Food Containers Used for Food Preservation in Cameroon

SSRN Electronic Journal (2022)

,

10.2139/SSRN.4250722

Fernandez, Juliette and Machado, Anthony K. and Lyonnais, Sébastien and Chamontin, Célia and Gärtner, Kathleen and Léger, Thibaut and Henriquet, Corinne and Garcia, Camille and Portilho, Débora M. and Pugnière, Martine and Chaloin, Laurent and Muriaux, Delphine and Yamauchi, Yohei and Blaise, Mickaël and Nisole, Sébastien and Arhel, Nathalie J.

Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating

Nature Microbiology (2019)

4, 1840-1850

10.1038/S41564-019-0575-6

Ouahrani-Bettache, Safia and Jiménez De Bagüés, María P. and De La Garza, Jorge and Freddi, Luca and Bueso, Juan P. and Lyonnais, Sébastien and Al Dahouk, Sascha and De Biase, Daniela and Köhler, Stephan and Occhialini, Alessandra

Lethality of Brucella microti in a murine model of infection depends on the wbkE gene involved in O-polysaccharide synthesis

Virulence (2019)

10, 868-878

10.1080/21505594.2019.1682762

Küssau, Tanja and Van Wyk, Niël and Johansen, Matt D. and Alsarraf, Husam M. A. B. and Neyret, Aymeric and Hamela, Claire and Sørensen, Kasper K. and Thygesen, Mikkel B. and Beauvineau, Claire and Kremer, Laurent and Blaise, Mickaël

Functional Characterization of the N-Acetylmuramyl-l-Alanine Amidase, Ami1, from Mycobacterium abscessus

Cells (2020)

9, 2410

10.3390/CELLS9112410

Inamdar, Kaushik and Tsai, Feng-Ching and Dibsy, Rayane and de Poret, Aurore and Manzi, John and Merida, Peggy and Muller, Remi and Lappalainen, Pekka and Roingeard, Philippe and Mak, Johnson and Bassereau, Patricia and Favard, Cyril and Muriaux, Delphine

Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53

eLife (2021)

10,

10.7554/ELIFE.67321

Lyonnais, Sébastien and Hénaut, Mathilde and Neyret, Aymeric and Merida, Peggy and Cazevieille, Chantal and Gros, Nathalie and Chable-Bessia, Christine and Muriaux, Delphine

Atomic force microscopy analysis of native infectious and inactivated SARS-CoV-2 virions

Scientific Reports (2021)

11,

10.1038/S41598-021-91371-4

Blain, Hubert and Tuaillon, Edouard and Gamon, Lucie and Pisoni, Amandine and Miot, Stéphanie and Delpui, Valentin and Si-Mohamed, Nejm and Niel, Clémence and Rolland, Yves and Montes, Brigitte and Groc, Soraya and Rafasse, Sophia and Dupuy, Anne-Marie and Gros, Nathalie and Muriaux, Delphine and Picot, Marie-Christine and Bousquet, Jean

Receptor binding domain-IgG levels correlate with protection in residents facing SARS-CoV-2 B.1.1.7 outbreaks

Allergy (2022)

77, 1885-1894

10.1111/ALL.15142

Arone, Coline and Dibsy, Rayane and Inamdar, Kaushik and Lyonnais, Sébastien and Arhel, Nathalie J. and Favard, Cyril and Muriaux, Delphine

Illuminating the nanoscopic world of viruses by fluorescence super-resolution microscopy

Virologie (2021)

25, 47-60

10.1684/VIR.2021.0908

Chable-Bessia, Christine and Boullé, Charlotte and Neyret, Aymeric and Swain, Jitendriya and Hénaut, Mathilde and Merida, Peggy and Gros, Nathalie and Makinson, Alain and Lyonnais, Sébastien and Chesnais, Cédric and Muriaux, Delphine

Low Selectivity Indices of Ivermectin and Macrocyclic Lactones on SARS-CoV-2 Replication In Vitro

COVID (2022)

2, 60-75

10.3390/COVID2010005

Constant, Orianne and Barthelemy, Jonathan and Bolloré, Karine and Tuaillon, Edouard and Gosselet, Fabien and Chable-Bessia, Christine and Merida, Peggy and Muriaux, Delphine and Van de Perre, Philippe and Salinas, Sara and Simonin, Yannick

SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects

Frontiers in Immunology (2021)

12,

10.3389/FIMMU.2021.697329

Lyonnais, Sébastien and Sadiq, S. Kashif and Lorca-Oró, Cristina and Dufau, Laure and Nieto-Marquez, Sara and Escribà, Tuixent and Gabrielli, Natalia and Tan, Xiao and Ouizougun-Oubari, Mohamed and Okoronkwo, Josephine and Reboud-Ravaux, Michèle and Gatell, José Maria and Marquet, Roland and Paillart, Jean-Christophe and Meyerhans, Andreas and Tisné, Carine and Gorelick, Robert J. and Mirambeau, Gilles

The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation

Viruses (2021)

13, 2312

10.3390/V13112312

de la Garza-García, Jorge A. and Ouahrani-Bettache, Safia and Lyonnais, Sébastien and Ornelas-Eusebio, Erika and Freddi, Luca and Al Dahouk, Sascha and Occhialini, Alessandra and Köhler, Stephan

Comparative Genome-Wide Transcriptome Analysis of Brucella suis and Brucella microti Under Acid Stress at pH 4.5: Cold Shock Protein CspA and Dps Are Associated With Acid Resistance of B. microti

Frontiers in Microbiology (2021)

12,

10.3389/FMICB.2021.794535

Bessis, Didier and Trouillet-Assant, Sophie and Secco, Léo-Paul and Bardin, Nathalie and Blanc, Brigitte and Blatière, Véronique and Chable-Bessia, Christine and Delfour, Christophe and Girard, Céline and Richard, Jean-Christophe and Gros, Nathalie and Le Moing, Vincent and Molinari, Nicolas and Pallure, Valérie and Pisoni, Amandine and Raison-Peyron, Nadia and Reynaud, Elisa and Schwob, Émilie and Pescarmona, Rémi and Samaran, Quentin and Willems, Marjolaine and Vincent, Thierry and Sofonea, Mircea T. and Belot, Alexandre and Tuaillon, Édouard

COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response

British Journal of Dermatology (2022)

187, 1032-1035

10.1111/BJD.21820

Ibanes, Sandy and El-Alaoui, Fatima and Lai-Kee-Him, Joséphine and Cazevieille, Chantal and Hoh, François and Lyonnais, Sébastien and Bron, Patrick and Cipelletti, Luca and Picas, Laura and Piatti, Simonetta

The Syp1/FCHo2 protein induces septin filament bundling through its intrinsically disordered domain

Cell Reports (2022)

41, 111765

10.1016/J.CELREP.2022.111765

Bonaventure, Boris and Rebendenne, Antoine and Chaves Valadão, Ana Luiza and Arnaud-Arnould, Mary and Gracias, Ségolène and Garcia de Gracia, Francisco and McKellar, Joe and Labaronne, Emmanuel and Tauziet, Marine and Vivet-Boudou, Valérie and Bernard, Eric and Briant, Laurence and Gros, Nathalie and Djilli, Wassila and Courgnaud, Valérie and Parrinello, Hugues and Rialle, Stéphanie and Blaise, Mickaël and Lacroix, Laurent and Lavigne, Marc and Paillart, Jean-Christophe and Ricci, Emiliano P and Schulz, Reiner and Jouvenet, Nolwenn and Moncorgé, Olivier and Goujon, Caroline

The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses

EMBO reports (2022)

23,

10.15252/EMBR.202154061

Boutonnet, Cécile and Lyonnais, Sébastien and Alpha-Bazin, Beatrice and Armengaud, Jean and Château, Alice and Duport, Catherine

Dynamic Profile of S-Layer Proteins Controls Surface Properties of Emetic Bacillus cereus AH187 Strain

Frontiers in Microbiology (2022)

13,

10.3389/FMICB.2022.937862

Tuaillon, Edouard and Pisoni, Amandine and Veyrenche, Nicolas and Rafasse, Sophia and Niel, Clémence and Gros, Nathalie and Muriaux, Delphine and Picot, Marie-Christine and Aouinti, Safa and Van de Perre, Philippe and Bousquet, Jean and Blain, Hubert

Antibody response after first and second BNT162b2 vaccination to predict the need for subsequent injections in nursing home residents

Scientific Reports (2022)

12,

10.1038/S41598-022-18041-X

Laplantine, Emmanuel and Chable-Bessia, Christine and Oudin, Anne and Swain, Jitendryia and Soria, Adèle and Merida, Peggy and Gourdelier, Manon and Mestiri, Sarra and Besseghe, Indira and Bremaud, Erwan and Neyret, Aymeric and Lyonnais, Sebastien and Favard, Cyril and Benaroch, Philippe and Hubert, Mathieu and Schwartz, Olivier and Guerin, Maryse and Danckaert, Anne and Del Nery, Elaine and Muriaux, Delphine and Weil, Robert

The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-kappaB signaling

iScience (2022)

25, 105066

10.1016/J.ISCI.2022.105066

Gourdelier, Manon and Swain, Jitendriya and Arone, Coline and Mouttou, Anita and Bracquemond, David and Merida, Peggy and Saffarian, Saveez and Lyonnais, Sébastien and Favard, Cyril and Muriaux, Delphine

Optimized production and fluorescent labeling of SARS-CoV-2 virus-like particles

Scientific Reports (2022)

12,

10.1038/S41598-022-18681-Z

Salehi, Hamideh and Ramoji, Anuradha and Mougari, Said and Merida, Peggy and Neyret, Aymeric and Popp, Jurgen and Horvat, Branka and Muriaux, Delphine and Cuisinier, Frederic

Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy

Communications Chemistry (2022)

5,

10.1038/S42004-022-00702-7

Houbron, Élisabeth and Mockly, Sophie and Rafasse, Sophia and Gros, Nathalie and Muriaux, Delphine and Seitz, Hervé

Biochemistry-informed design selects potent siRNAs against SARS-CoV-2

RNA Biology (2023)

20, 272-280

10.1080/15476286.2023.2217400

Tarrés-Solé, Aleix and Battistini, Federica and Gerhold, Joachim M and Piétrement, Olivier and Martínez-García, Belén and Ruiz-López, Elena and Lyonnais, Sébastien and Bernadó, Pau and Roca, Joaquim and Orozco, Modesto and Le Cam, Eric and Sedman, Juhan and Solà, Maria

Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism

Nucleic Acids Research (2023)

51, 5864-5882

10.1093/NAR/GKAD397

Cherkashchenko, Liubov and Gros, Nathalie and Trausch, Alice and Neyret, Aymeric and Hénaut, Mathilde and Dubois, Gregor and Villeneuve, Matthieu and Chable-Bessia, Christine and Lyonnais, Sébastien and Merits, Andres and Muriaux, Delphine

Validation of flavivirus infectious clones carrying fluorescent markers for antiviral drug screening and replication studies

Frontiers in Microbiology (2023)

14,

10.3389/FMICB.2023.1201640

Assou, Said and Ahmed, Engi and Morichon, Lisa and Nasri, Amel and Foisset, Florent and Bourdais, Carine and Gros, Nathalie and Tieo, Sonia and Petit, Aurelie and Vachier, Isabelle and Muriaux, Delphine and Bourdin, Arnaud and De Vos, John

The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2

International Journal of Molecular Sciences (2023)

24, 12017

10.3390/IJMS241512017

Nguyen, Minh-Chau and Bonnaud, Peter and Dibsy, Rayane and Maucort, Guillaume and Lyonnais, Sébastien and Muriaux, Delphine and Bon, Pierre

Label-Free Single Nanoparticle Identification and Characterization in Demanding Environment, Including Infectious Emergent Virus

Small (2024)

20,

10.1002/SMLL.202304564

Alcaraz, Matthéo and Lyonnais, Sébastien and Ghosh, Chandramouli and Aguilera-Correa, John Jairo and Richeter, Sébastien and Ulrich, Sébastien and Kremer, Laurent

Evaluation and activity of new porphyrin-peptide cage-type conjugates for the photoinactivation of Mycobacterium abscessus

Microbiology Spectrum (2024)

12,

10.1128/SPECTRUM.00006-24

Schlosser-Perrin, Léo and Holzmuller, Philippe and Fernandez, Bernard and Miotello, Guylaine and Dahmani, Noureddine and Neyret, Aymeric and Bertagnoli, Stéphane and Armengaud, Jean and Caufour, Philippe

Constitutive proteins of lumpy skin disease virion assessed by next-generation proteomics

Journal of Virology (2023)

97,

10.1128/JVI.00723-23

Abba Moussa, Daouda and Vazquez, Mario and Chable-Bessia, Christine and Roux-Portalez, Vincent and Tamagnini, Elia and Pedotti, Mattia and Simonelli, Luca and Ngo, Giang and Souchard, Manon and Lyonnais, Sebastien and Chentouf, Myriam and Gros, Nathalie and Marsile-Medun, Soledad and Dinter, Heiko and Pugnière, Martine and Martineau, Pierre and Varani, Luca and Juan, Manel and Calderon, Hugo and Naranjo-Gomez, Mar and Pelegrin, Mireia

Discovery of a pan anti-SARS-CoV-2 monoclonal antibody with highly efficient infected cell killing capacity for novel immunotherapeutic approaches

Emerging Microbes & Infections (2025)

14,

10.1080/22221751.2024.2432345

Rey-Cadilhac, Félix and Rachenne, Florian and Marquant, Antonin and Kee Him, Josephine Lai and Ancelin, Aurélie and Foisor, Veronica and Morille, Marie and Lyonnais, Sébastien and Cazevieille, Chantal and Missé, Dorothée and Pompon, Julien

Characterization of size distribution and markers for mosquito extracellular vesicles

Frontiers in Cell and Developmental Biology (2025)

13,

10.3389/FCELL.2025.1497795

El Alaoui, Fatima and Al-Akiki, Isabelle and Ibanes, Sandy and Lyonnais, Sébastien and Sanchez-Fuentes, David and Desgarceaux, Rudy and Cazevieille, Chantal and Blanchard, Marie-Pierre and Parmeggiani, Andrea and Carretero-Genevrier, Adrian and Piatti, Simonetta and Picas, Laura

Septin assemblies promote the lipid organization of membranes

Structure (2025)

33, 451-464.e5

10.1016/J.STR.2025.01.005

Jaber, Rim and Planchon, Aline and Mathieu-Rivet, Elodie and Kiefer-Meyer, Marie-Christine and Zahid, Abderrakib and Plasson, Carole and Pamlard, Olivier and Beaupierre, Sandra and Trouvé, Jean-Paul and Guillou, Catherine and Driouich, Azeddine and Follet-Gueye, Marie-Laure and Mollet, Jean-Claude

Identification of two compounds able to improve flax resistance towards Fusarium oxysporum infection

Plant Science (2020)

301, 110690

10.1016/J.PLANTSCI.2020.110690

Weinhäupl, Katharina and Meuret, Louis and Desrat, Sandy and Roussi, Fanny and Morellet, Nelly and Beaupierre, Sandra and Guillou, Catherine and van Heijenoort, Carine and Abian, Olga and Vega, Sonia and Wolf, Ian and Akopian, Tatos and Krandor, Olga and Rubin, Eric and Velazquez-Campoy, Adrian and Gauto, Diego and Fraga, Hugo

Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development

Scientific Reports (2025)

15,

10.1038/S41598-025-87535-1

He, Ben and Karroum, Nour Bou and Gealageas, Ronan and Mauvais, François-Xavier and Warenghem, Sandrine and Roignant, Matthieu and Kraupner, Nicolas and Lam, Bao Vy and Azaroual, Nathalie and Ultré, Vincent and Rech, Alexandre and Lesire, Laetitia and Couturier, Cyril and Leroux, Florence and van Endert, Peter and Deprez, Benoit and Deprez-Poulain, Rebecca

Discovery of New Nanomolar Selective IRAP Inhibitors

Journal of Medicinal Chemistry (2025)

68, 4168-4195

10.1021/ACS.JMEDCHEM.4C01744

Lakli, Mounia and Dumont, Julie and Vauthier, Virginie and Charton, Julie and Crespi, Veronica and Banet, Manon and Riahi, Yosra and Ben Saad, Amel and Mareux, Elodie and Lapalus, Martine and Gonzales, Emmanuel and Jacquemin, Emmanuel and Di Meo, Florent and Deprez, Benoit and Leroux, Florence and Falguières, Thomas

Identification of new correctors for traffic-defective ABCB4 variants by a high-content screening approach

Communications Biology (2024)

7,

10.1038/S42003-024-06590-Y

Fougiaxis, Vasileios and Barcherini, Valentina and Petrovic, Milena M. and Sierocki, Pierre and Warenghem, Sandrine and Leroux, Florence and Bou Karroum, Nour and Petit-Cancelier, Fabien and Rodeschini, Vincent and Roche, Didier and Deprez, Benoit and Deprez-Poulain, Rebecca

First fragment-based screening identifies new chemotypes inhibiting ERAP1-metalloprotease

European Journal of Medicinal Chemistry (2024)

280, 116926

10.1016/J.EJMECH.2024.116926

Honfozo, Ariane and Houngue, Rodrigue and Vandeputte, Alexandre and Dechavanne, Sébastien and Nouatin, Odilon and Atindehou, Ménonvè Cynthia and Fanou, Lucie Ayi and Massougbodji, Achille and Dechavanne, Célia and Brodin, Priscille and Tomavo, Stanislas

An image-based high-content screening for compounds targeting Toxoplasma gondii repurposed inhibitors effective against the malaria parasite Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology (2023)

13,

10.3389/FCIMB.2023.1102551

Desmarets, Lowiese and Millot, Marion and Chollet-Krugler, Marylène and Boustie, Joël and Camuzet, Charline and François, Nathan and Rouillé, Yves and Belouzard, Sandrine and Tomasi, Sophie and Mambu, Lengo and Séron, Karin

Lichen or Associated Micro-Organism Compounds Are Active against Human Coronaviruses

Viruses (2023)

15, 1859

10.3390/V15091859

Belhaouane, Imène and Pochet, Amine and Chatagnon, Jonathan and Hoffmann, Eik and Queval, Christophe J. and Deboosère, Nathalie and Boidin-Wichlacz, Céline and Majlessi, Laleh and Sencio, Valentin and Heumel, Séverine and Vandeputte, Alexandre and Werkmeister, Elisabeth and Fievez, Laurence and Bureau, Fabrice and Rouillé, Yves and Trottein, François and Chamaillard, Mathias and Brodin, Priscille and Machelart, Arnaud

Tirap controls Mycobacterium tuberculosis phagosomal acidification

PLOS Pathogens (2023)

19, e1011192

10.1371/JOURNAL.PPAT.1011192

Plé, Coline and Tam, Heng-Keat and Vieira Da Cruz, Anais and Compagne, Nina and Jiménez-Castellanos, Juan-Carlos and Müller, Reinke T. and Pradel, Elizabeth and Foong, Wuen Ee and Malloci, Giuliano and Ballée, Alexia and Kirchner, Moritz A. and Moshfegh, Parisa and Herledan, Adrien and Herrmann, Andrea and Deprez, Benoit and Willand, Nicolas and Vargiu, Attilio Vittorio and Pos, Klaas M. and Flipo, Marion and Hartkoorn, Ruben C.

Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps

Nature Communications (2022)

13,

10.1038/S41467-021-27726-2

Desmarets, Lowiese and Callens, Nathalie and Hoffmann, Eik and Danneels, Adeline and Lavie, Muriel and Couturier, Cyril and Dubuisson, Jean and Belouzard, Sandrine and Rouillé, Yves

A reporter cell line for the automated quantification of SARS-CoV-2 infection in living cells

Frontiers in Microbiology (2022)

13,

10.3389/FMICB.2022.1031204

Moureu, Sophie and Caradec, Thibault and Trivelli, Xavier and Drobecq, Hervé and Beury, Delphine and Bouquet, Peggy and Caboche, Segolene and Desmecht, Eva and Maurier, Florence and Muharram, Ghaffar and Villemagne, Baptiste and Herledan, Adrien and Hot, David and Willand, Nicolas and Hartkoorn, Ruben Christiaan

Rubrolone production by Dactylosporangium vinaceum: biosynthesis, modulation and possible biological function

Applied Microbiology and Biotechnology (2021)

105, 5541-5551

10.1007/S00253-021-11404-W

Juillot, Dimitri and Cornilleau, Charlène and Deboosere, Nathalie and Billaudeau, Cyrille and Evouna-Mengue, Parfait and Lejard, Véronique and Brodin, Priscille and Carballido-López, Rut and Chastanet, Arnaud

A High-Content Microscopy Screening Identifies New Genes Involved in Cell Width Control in Bacillus subtilis

mSystems (2021)

6,

10.1128/MSYSTEMS.01017-21

Deboosere, Nathalie and Belhaouane, Imène and Machelart, Arnaud and Hoffmann, Eik and Vandeputte, Alexandre and Brodin, Priscille

High-Content Analysis Monitoring Intracellular Trafficking and Replication of Mycobacterium tuberculosis Inside Host Cells

Methods in Molecular Biology (2021)

, 649-702

10.1007/978-1-0716-1460-0_29

Moraski, Garrett C. and Deboosère, Nathalie and Marshall, Kate L. and Weaver, Heath A. and Vandeputte, Alexandre and Hastings, Courtney and Woolhiser, Lisa and Lenaerts, Anne J. and Brodin, Priscille and Miller, Marvin J.

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds

PLOS ONE (2020)

15, e0227224

10.1371/JOURNAL.PONE.0227224

Mendes, Tiago and Herledan, Adrien and Leroux, Florence and Deprez, Benoit and Lambert, Jean-Charles and Kilinc, Devrim

High-Content Screening for Protein-Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons

Current Protocols in Cell Biology (2020)

86,

10.1002/CPCB.100

Song, Ok-Ryul and Brodin, Priscille and Buchrieser, Carmen and Escoll, Pedro

Mitochondrial Dynamics and Activity in Legionella-Infected Cells

Methods in Molecular Biology (2019)

, 205-220

10.1007/978-1-4939-9048-1_13

Sartori, Maxime and Mendes, Tiago and Desai, Shruti and Lasorsa, Alessia and Herledan, Adrien and Malmanche, Nicolas and Mäkinen, Petra and Marttinen, Mikael and Malki, Idir and Chapuis, Julien and Flaig, Amandine and Vreulx, Anaïs-Camille and Ciancia, Marion and Amouyel, Philippe and Leroux, Florence and Déprez, Benoit and Cantrelle, François-Xavier and Maréchal, Damien and Pradier, Laurent and Hiltunen, Mikko and Landrieu, Isabelle and Kilinc, Devrim and Herault, Yann and Laporte, Jocelyn and Lambert, Jean-Charles

BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Acta Neuropathologica (2019)

138, 631-652

10.1007/S00401-019-02017-9

Prevet, Hugues and Moune, Martin and Tanina, Abdalkarim and Kemmer, Christian and Herledan, Adrien and Frita, Rosangela and Wohlkönig, Alexandre and Bourotte, Marilyne and Villemagne, Baptiste and Leroux, Florence and Gitzinger, Marc and Baulard, Alain R. and Déprez, Benoit and Wintjens, René and Willand, Nicolas and Flipo, Marion

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2

European Journal of Medicinal Chemistry (2019)

167, 426-438

10.1016/J.EJMECH.2019.02.023

Leroux, Florence and Bosc, Damien and Beghyn, Terence and Hermant, Paul and Warenghem, Sandrine and Landry, Valérie and Pottiez, Virginie and Guillaume, Valentin and Charton, Julie and Herledan, Adrien and Urata, Sarah and Liang, Wenguang and Sheng, Li and Tang, Wei-Jen and Deprez, Benoit and Deprez-Poulain, Rebecca

Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening

European Journal of Medicinal Chemistry (2019)

179, 557-566

10.1016/J.EJMECH.2019.06.057

Song, Ok-Ryul and Queval, Christophe J and Iantomasi, Raffaella and Delorme, Vincent and Marion, Sabrina and Veyron-Churlet, Romain and Werkmeister, Elisabeth and Popoff, Michka and Ricard, Isabelle and Jouny, Samuel and Deboosere, Nathalie and Lafont, Frank and Baulard, Alain and Yeramian, Edouard and Marsollier, Laurent and Hoffmann, Eik and Brodin, Priscille

ArfGAP1 restrictsMycobacterium tuberculosisentry by controlling the actin cytoskeleton

EMBO reports (2018)

19, 29-42

10.15252/EMBR.201744371

Riva, Laura and Song, Ok-ryul and Prentoe, Jannick and Helle, François and L'homme, Laurent and Gattolliat, Charles-Henry and Vandeputte, Alexandre and Fénéant, Lucie and Belouzard, Sandrine and Baumert, Thomas F. and Asselah, Tarik and Bukh, Jens and Brodin, Priscille and Cocquerel, Laurence and Rouillé, Yves and Dubuisson, Jean

Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

Journal of Virology (2018)

92,

10.1128/JVI.01982-17

Ziada, Sonia and Braka, Abdennour and Diharce, Julien and Aci-Sèche, Samia and Bonnet, Pascal

Enhanced Molecular Dynamics Methods Applied to Drug Design Projects

Methods in Molecular Biology (2018)

, 403-426

10.1007/978-1-4939-7756-7_20

Soleilhac, Emmanuelle and Brillet-Guéguen, Loraine and Roussel, Véronique and Prudent, Renaud and Touquet, Bastien and Dass, Sheena and Aci-Sèche, Samia and Kasam, Vinod and Barette, Caroline and Imberty, Anne and Breton, Vincent and Vantard, Marylin and Horvath, Dragos and Botté, Cyrille and Tardieux, Isabelle and Roy, Sylvaine and Maréchal, Eric and Lafanechère, Laurence

Specific Targeting of Plant and Apicomplexa Parasite Tubulin through Differential Screening Using In Silico and Assay-Based Approaches

International Journal of Molecular Sciences (2018)

19, 3085

10.3390/IJMS19103085

Couly, Florence and Harari, Marine and Dubouilh-Benard, Carole and Bailly, Laetitia and Petit, Emilie and Diharce, Julien and Bonnet, Pascal and Meijer, Laurent and Fruit, Corinne and Besson, Thierry

Development of Kinase Inhibitors via Metal-Catalyzed C-H Arylation of 8-Alkyl-thiazolo[5,4-f]-quinazolin-9-ones Designed by Fragment-Growing Studies

Molecules (2018)

23, 2181

10.3390/MOLECULES23092181

Laine, Sophie and Bonnet, Célia S. and Kálmán, Ferenc K. and Garda, Zoltán and Pallier, Agnès and Caillé, Fabien and Suzenet, Franck and Tircsó, Gyula and Tóth, Éva

Mn2+ complexes of open-chain ligands with a pyridine backbone: less donor atoms lead to higher kinetic inertness

New Journal of Chemistry (2018)

42, 8012-8020

10.1039/C8NJ00648B

Carles, Fabrice and Bourg, Stéphane and Meyer, Christophe and Bonnet, Pascal

PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials

Molecules (2018)

23, 908

10.3390/MOLECULES23040908

Driowya, Mohsine and Allouchi, Hassan and Gally, José Manuel and Bonnet, Pascal and Guillaumet, Gérald

Synthesis of novel series of 7,7'-(substituted methylene)bis-imidazo[1,2-b]pyrazoles via an acid catalyzed one-pot three-component reaction

New Journal of Chemistry (2018)

42, 5728-5741

10.1039/C7NJ05088G

Khater, Syame and Canault, Baptiste and Azzimani, Taoufik and Bonnet, Pascal and West, Caroline

Thermodynamic enantioseparation behavior of phenylthiohydantoin-amino acid derivatives in supercritical fluid chromatography on polysaccharide chiral stationary phases

Journal of Separation Science (2018)

41, 1450-1459

10.1002/JSSC.201701196

Diharce, Julien and Cueto, Mickaël and Beltramo, Massimiliano and Aucagne, Vincent and Bonnet, Pascal

In Silico Peptide Ligation: Iterative Residue Docking and Linking as a New Approach to Predict Protein-Peptide Interactions

Molecules (2019)

24, 1351

10.3390/MOLECULES24071351

Sirbu, Doina and Diharce, Julien and Martinic, Ivana and Chopin, Nicolas and Eliseeva, Svetlana V. and Guillaumet, Gérald and Petoud, Stéphane and Bonnet, Pascal and Suzenet, Franck

An original class of small sized molecules as versatile fluorescent probes for cellular imaging

Chemical Communications (2019)

55, 7776-7779

10.1039/C9CC03765A

Duval, Johanna and Colas, Cyril and Bonnet, Pascal and Lesellier, Eric

Hyphenation of ultra-high performance supercritical fluid chromatography with atmospheric pressure chemical ionisation high resolution mass spectrometry...

Journal of Chromatography A (2019)

1596, 199-208

10.1016/J.CHROMA.2019.03.018

Driowya, Mohsine and Guillot, Régis and Bonnet, Pascal and Guillaumet, Gérald

Development of Novel and Efficient Processes for the Synthesis of 5-Amino and 5-Iminoimidazo[1,2-a]imidazoles via Three-Component Reaction Catalyzed by Zirconium(IV) Chloride

Frontiers in Chemistry (2019)

7,

10.3389/FCHEM.2019.00457

Bournez, Colin and Carles, Fabrice and Peyrat, Gautier and Aci-Sèche, Samia and Bourg, Stéphane and Meyer, Christophe and Bonnet, Pascal

Comparative Assessment of Protein Kinase Inhibitors in Public Databases and in PKIDB

Molecules (2020)

25, 3226

10.3390/MOLECULES25143226

Fogha, Jade and Diharce, Julien and Obled, Alan and Aci-Sèche, Samia and Bonnet, Pascal

Computational Analysis of Crystallization Additives for the Identification of New Allosteric Sites

ACS Omega (2020)

5, 2114-2122

10.1021/ACSOMEGA.9B02697

Raimbault, Adrien and Ma, Cam Mai Anh and Ferri, Martina and Bäurer, Stefanie and Bonnet, Pascal and Bourg, Stéphane and Lämmerhofer, Michael and West, Caroline

Cinchona-based zwitterionic stationary phases: Exploring retention and enantioseparation mechanisms in supercritical fluid chromatography with a fragmentation approach

Journal of Chromatography A (2020)

1612, 460689

10.1016/J.CHROMA.2019.460689

Gally, José-Manuel and Bourg, Stéphane and Fogha, Jade and Do, Quoc-Tuan and Aci-Sèche, Samia and Bonnet, Pascal

VSPrep: A KNIME Workflow for the Preparation of Molecular Databases for Virtual Screening

Current Medicinal Chemistry (2020)

27, 6480-6494

10.2174/0929867326666190614160451

Braka, Abdennour and Garnier, Norbert and Bonnet, Pascal and Aci-Sèche, Samia

Residence Time Prediction of Type 1 and 2 Kinase Inhibitors from Unbinding Simulations

Journal of Chemical Information and Modeling (2020)

60, 342-348

10.1021/ACS.JCIM.9B00497

Faarasse, Soukaina and El Kazzouli, Saïd and Bourzikat, Otmane and Bourg, Stéphane and Aci-Sèche, Samia and Bonnet, Pascal and Suzenet, Franck and Guillaumet, Gérald

Palladium-Catalyzed Regioselective C-H Arylation of 4-Azaindazole at C3, C5 and C7 Positions

Advanced Synthesis & Catalysis (2021)

363, 3937-3945

10.1002/ADSC.202001421

Buron, Frédéric and Rodrigues, Nuno and Saurat, Thibault and Hiebel, Marie Aude and Bourg, Stéphane and Bonnet, Pascal and Nehmé, Reine and Morin, Philippe and Percina, Nathalie and Corret, Justine and Vallée, Béatrice and le Guevel, Remy and Jourdan, Marie-Lise and Bénédetti, Hélène and Routier, Sylvain

Design, Synthesis and SAR in 2,4,7-Trisubstituted Pyrido[3,2-d]Pyrimidine Series as Novel PI3K/mTOR Inhibitors

Molecules (2021)

26, 5349

10.3390/MOLECULES26175349

Miret-Casals, Laia and Van De Putte, Sander and Aerssens, Dorien and Diharce, Julien and Bonnet, Pascal and Madder, Annemieke

Equipping Coiled-Coil Peptide Dimers With Furan Warheads Reveals Novel Cross-Link Partners

Frontiers in Chemistry (2022)

9,

10.3389/FCHEM.2021.799706

Ziada, Sonia and Diharce, Julien and Raimbaud, Eric and Aci-Sèche, Samia and Ducrot, Pierre and Bonnet, Pascal

Estimation of Drug-Target Residence Time by Targeted Molecular Dynamics Simulations

Journal of Chemical Information and Modeling (2022)

62, 5536-5549

10.1021/ACS.JCIM.2C00852

Libouban, Pierre-Yves and Aci-Sèche, Samia and Gómez-Tamayo, Jose Carlos and Tresadern, Gary and Bonnet, Pascal

The Impact of Data on Structure-Based Binding Affinity Predictions Using Deep Neural Networks

International Journal of Molecular Sciences (2023)

24, 16120

10.3390/IJMS242216120

Arora, Rohit and Linders, Joannes T.M. and Aci-Sèche, Samia and Verheyen, Thomas and Van Heerde, Erika and Brehmer, Dirk and Chaikuad, Apirat and Knapp, Stefan and Bonnet, Pascal

Design, synthesis and characterisation of a novel type II B-RAF paradox breaker inhibitor

European Journal of Medicinal Chemistry (2023)

250, 115231

10.1016/J.EJMECH.2023.115231

Aci-Sèche, Samia and Bourg, Stéphane and Bonnet, Pascal and Rebehmed, Joseph and de Brevern, Alexandre G. and Diharce, Julien

A perspective on the sharing of docking data

Data in Brief (2023)

49, 109386

10.1016/J.DIB.2023.109386

Bournez, Colin and Gally, José-Manuel and Aci-Sèche, Samia and Bernard, Philippe and Bonnet, Pascal

Virtual screening of natural products to enhance melanogenosis

Molecular Informatics (2024)

43,

10.1002/MINF.202300335

Champiré, Anthony and Berabez, Rayan and Braka, Abdennour and Cosson, Aurélie and Corret, Justine and Girardin, Caroline and Serrano, Amandine and Aci-Sèche, Samia and Bonnet, Pascal and Josselin, Béatrice and Brindeau, Pierre and Ruchaud, Sandrine and Leguevel, Rémy and Chatterjee, Deep and Mathea, Sebastian and Knapp, Stefan and Brion, Régis and Verrecchia, Franck and Vallée, Béatrice and Plé, Karen and Bénédetti, Hélène and Routier, Sylvain

Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization

European Journal of Medicinal Chemistry (2024)

271, 116391

10.1016/J.EJMECH.2024.116391

Ziada, Sonia and Diharce, Julien and Serillon, Dylan and Bonnet, Pascal and Aci-Sèche, Samia

Highlighting the Major Role of Cyclin C in Cyclin-Dependent Kinase 8 Activity through Molecular Dynamics Simulations

International Journal of Molecular Sciences (2024)

25, 5411

10.3390/IJMS25105411

Yaacoub, Katherine and Pedeux, Rémy and Lafite, Pierre and Jarry, Ulrich and Aci-Sèche, Samia and Bonnet, Pascal and Daniellou, Richard and Guillaudeux, Thierry

The Identification of New c-FLIP Inhibitors for Restoring Apoptosis in TRAIL-Resistant Cancer Cells

Current Issues in Molecular Biology (2024)

46, 710-728

10.3390/CIMB46010046

Moreau, Clémentine and Lukacevic, Tea and Pallier, Agnès and Sobilo, Julien and Aci-Sèche, Samia and Garnier, Norbert and Même, Sandra and Tóth, Éva and Lacerda, Sara

Peptide-Conjugated MRI Probe Targeted to Netrin-1, a Novel Metastatic Breast Cancer Biomarker

Bioconjugate Chemistry (2024)

35, 265-275

10.1021/ACS.BIOCONJCHEM.3C00558

Belhocine, Abderazak and Veglianese, Pietro and Hounsou, Candide and Dupuis, Elodie and Acher, Francine and Durroux, Thierry and Goudet, Cyril and Pin, Jean-Philippe

Profiling of orthosteric and allosteric group-III metabotropic glutamate receptor ligands on various G protein-coupled receptors with Tag-lite® assays

Neuropharmacology (2018)

140, 233-245

10.1016/J.NEUROPHARM.2018.07.032

Nasrallah, Chady and Rottier, Karine and Marcellin, Romain and Compan, Vincent and Font, Joan and Llebaria, Amadeu and Pin, Jean-Philippe and Banères, Jean-Louis and Lebon, Guillaume

Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs

Scientific Reports (2018)

8,

10.1038/S41598-018-22729-4

Perkovska, Sanja and Méjean, Catherine and Ayoub, Mohammed Akli and Li, Juan and Hemery, Floriane and Corbani, Maithé and Laguette, Nadine and Ventura, Maria-Angeles and Orcel, Hélène and Durroux, Thierry and Mouillac, Bernard and Mendre, Christiane

V1bvasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase

Traffic (2018)

19, 58-82

10.1111/TRA.12535

Selvam, Chelliah and Lemasson, Isabelle A. and Brabet, Isabelle and Oueslati, Nadia and Karaman, Berin and Cabaye, Alexandre and Tora, Amélie S. and Commare, Bruno and Courtiol, Tiphanie and Cesarini, Sara and McCort-Tranchepain, Isabelle and Rigault, Delphine and Mony, Laetitia and Bessiron, Thomas and McLean, Heather and Leroux, Frédéric R. and Colobert, Françoise and Daniel, Hervé and Goupil-Lamy, Anne and Bertrand, Hugues-Olivier and Goudet, Cyril and Pin, Jean-Philippe and Acher, Francine C.

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites

Journal of Medicinal Chemistry (2018)

61, 1969-1989

10.1021/ACS.JMEDCHEM.7B01438

Stewart, Gregory D. and Comps-Agrar, Laëtitia and Nørskov-Lauritsen, Lenea Blanc and Pin, Jean-Philippe and Kniazeff, Julie

Allosteric interactions between GABAB1 subunits control orthosteric binding sites occupancy within GABAB oligomers

Neuropharmacology (2018)

136, 92-101

10.1016/J.NEUROPHARM.2017.12.042

Tora, Amélie S. and Rovira, Xavier and Cao, Anne-Marinette and Cabayé, Alexandre and Olofsson, Linnéa and Malhaire, Fanny and Scholler, Pauline and Baik, Hayeon and Van Eeckhaut, Ann and Smolders, Ilse and Rondard, Philippe and Margeat, Emmanuel and Acher, Francine and Pin, Jean-Philippe and Goudet, Cyril

Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

Neuropharmacology (2018)

140, 275-286

10.1016/J.NEUROPHARM.2018.08.011

Zussy, C and Gómez-Santacana, X and Rovira, X and De Bundel, D and Ferrazzo, S and Bosch, D and Asede, D and Malhaire, F and Acher, F and Giraldo, J and Valjent, E and Ehrlich, I and Ferraguti, F and Pin, J-P and Llebaria, A and Goudet, C

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

Molecular Psychiatry (2018)

23, 509-520

10.1038/MP.2016.223

Zindel, Diana and Vol, Claire and Lecha, Odile and Bequignon, Isabelle and Bilgic, Merve and Vereecke, Marion and Charrier-Savournin, Fabienne and Romier, Maïté and Trinquet, Eric and Pin, Jean-Philippe and Pannequin, Julie and Roux, Thomas and Dupuis, Elodie and Prézeau, Laurent

HTRF® Total and Phospho-YAP (Ser127) Cellular Assays

Methods in Molecular Biology (2019)

, 153-166

10.1007/978-1-4939-8910-2_13

Hajj, Mariana and De Vita, Teresa and Vol, Claire and Renassia, Charlotte and Bologna, Jean-Charles and Brabet, Isabelle and Cazade, Magali and Pastore, Manuela and Blahos, Jaroslav and Labesse, Gilles and Pin, Jean-Philippe and Prézeau, Laurent

Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein-Coupled Receptor

Molecular Pharmacology (2019)

96, 233-246

10.1124/MOL.118.113019

Gentzsch, Christian and Seier, Kerstin and Drakopoulos, Antonios and Jobin, Marie-Lise and Lanoiselée, Yann and Koszegi, Zsombor and Maurel, Damien and Sounier, Rémy and Hübner, Harald and Gmeiner, Peter and Granier, Sébastien and Calebiro, Davide and Decker, Michael

Selective and Wash-Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single-Molecule Imaging of micro-Opioid Receptor Dimerization

Angewandte Chemie International Edition (2020)

59, 5958-5964

10.1002/ANIE.201912683

Liu, Hongkang and Yi, Ping and Zhao, Wenjing and Wu, Yuling and Acher, Francine and Pin, Jean-Philippe and Liu, Jianfeng and Rondard, Philippe

Illuminating the allosteric modulation of the calcium-sensing receptor

Proceedings of the National Academy of Sciences (2020)

117, 21711-21722

10.1073/PNAS.1922231117

Haubrich, Jordi and Font, Joan and Quast, Robert B. and Goupil-Lamy, Anne and Scholler, Pauline and Nevoltris, Damien and Acher, Francine and Chames, Patrick and Rondard, Philippe and Prézeau, Laurent and Pin, Jean-Philippe

A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers

Proceedings of the National Academy of Sciences (2021)

118,

10.1073/PNAS.2105848118

Zindel, Diana and Mensat, Patrick and Vol, Claire and Homayed, Zeinab and Charrier-Savournin, Fabienne and Trinquet, Eric and Banères, Jean-Louis and Pin, Jean-Philippe and Pannequin, Julie and Roux, Thomas and Dupuis, Elodie and Prézeau, Laurent

G protein-coupled receptors can control the Hippo/YAP pathway through Gq signaling

The FASEB Journal (2021)

35,

10.1096/FJ.202002159R

Cao, Anne-Marinette and Quast, Robert B. and Fatemi, Fataneh and Rondard, Philippe and Pin, Jean-Philippe and Margeat, Emmanuel

Allosteric modulators enhance agonist efficacy by increasing the residence time of a GPCR in the active state

Nature Communications (2021)

12,

10.1038/S41467-021-25620-5

Liu, Junke and Tang, Hengmin and Xu, Chanjuan and Zhou, Shengnan and Zhu, Xunying and Li, Yuanyuan and Prézeau, Laurent and Xu, Tao and Pin, Jean-Philippe and Rondard, Philippe and Ji, Wei and Liu, Jianfeng

Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor

Nature Communications (2022)

13,

10.1038/S41467-022-34056-4

Gazdarica, Matej and Noda, Judith and Durydivka, Oleh and Novosadova, Vendula and Mackie, Ken and Pin, Jean-Philippe and Prezeau, Laurent and Blahos, Jaroslav

SGIP1 modulates kinetics and interactions of the cannabinoid receptor 1 and G protein-coupled receptor kinase 3 signalosome

Journal of Neurochemistry (2022)

160, 625-642

10.1111/JNC.15569

Lecat-Guillet, Nathalie and Quast, Robert B. and Liu, Hongkang and Bourrier, Emmanuel and Møller, Thor C. and Rovira, Xavier and Soldevila, Stéphanie and Lamarque, Laurent and Trinquet, Eric and Liu, Jianfeng and Pin, Jean-Philippe and Rondard, Philippe and Margeat, Emmanuel

Concerted conformational changes control metabotropic glutamate receptor activity

Science Advances (2023)

9,

10.1126/SCIADV.ADF1378

Panarello, Silvia and González-Díez, Aleix and Berizzi, Alice E. and Malhaire, Fanny and Borràs-Tudurí, Roser and Rovira, Xavier and Serra, Carme and Prézeau, Laurent and Pin, Jean-Philippe and Goudet, Cyril and Llebaria, Amadeu and Gómez-Santacana, Xavier

Photoswitchable positive allosteric modulators of metabotropic glutamate receptor 4 to improve selectivity

iScience (2024)

27, 110123

10.1016/J.ISCI.2024.110123

Guigues, Adeline and Gimenez, Sandrine and Mettling, Clément and Maurel, Damien and Doumazane, Etienne and Prézeau, Laurent and François, Vincent and Corbeau, Pierre

The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication

AIDS (2024)

38, 1449-1459

10.1097/QAD.0000000000003931

Haubrich, Jordi and Zwier, Jurriaan M. and Charrier-Savournin, Fabienne and Prézeau, Laurent and Pin, Jean-Philippe

Different EGF-induced receptor dimer conformations for signaling and internalization

The FASEB Journal (2024)

38,

10.1096/FJ.202301209R

Meng, Jiyong and Xu, Chanjuan and Lafon, Pierre-André and Roux, Salomé and Mathieu, Michaël and Zhou, Rui and Scholler, Pauline and Blanc, Emilie and Becker, Jérôme A. J. and Le Merrer, Julie and González-Maeso, Javier and Chames, Patrick and Liu, Jianfeng and Pin, Jean-Philippe and Rondard, Philippe

Nanobody-based sensors reveal a high proportion of mGlu heterodimers in the brain

Nature Chemical Biology (2022)

18, 894-903

10.1038/S41589-022-01050-2

Gómez-Santacana, Xavier and Boutonnet, Marin and Martínez-Juvés, Carles and Cimadevila, Marta and Catena, Juanlo and Moutin, Enora and Roux, Thomas and Trinquet, Eric and Lamarque, Laurent and Perroy, Julie and Prézeau, Laurent and Zwier, Jurriaan M. and Pin, Jean-Philippe and Llebaria, Amadeu

A modular click ligand-directed approach to label endogenous dopamine D1 receptors in live cells

Communications Chemistry (2025)

8,

10.1038/S42004-025-01504-3

Linda Matignon and Nathalie Gros and Richmond Jean-François Kablan and Muriel Sylvestre and Jean-Didier Maréchal and Gerardo Cebrián-Torrejón and Laura Brelle

Study of the Toxicity and Antiviral Effect of Natural Compounds Extracted from Pseudospinx Tetrio and Allamanda Cathartica on SARS-CoV-2 Infection

Journal of Analytical Techniques and Research (2024)

42, 1--10

Peronne, Lauralie and Denarier, Eric and Rai, Ankit and Prudent, Renaud and Vernet, Audrey and Suzanne, Peggy and Ramirez-Rios, Sacnicté and Michallet, Sophie and Guidetti, Mélanie and Vollaire, Julien and Lucena-Agell, Daniel and Ribba, Anne-Sophie and Josserand, Véronique and Coll, Jean-Luc and Dallemagne, Patrick and Díaz, J. Fernando and Oliva, María Ángela and Sadoul, Karin and Akhmanova, Anna and Andrieux, Annie and Lafanechère, Laurence

Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells

Cancers (2020)

12, 2196

10.3390/CANCERS12082196

Riva, Clémence and Suzanne, Peggy and Charpentier, Gaël and Dulin, Fabienne and Halm-Lemeille, Marie-Pierre and Sopkova-de Oliveira Santos, Jana

In silico chemical library screening and experimental validation of novel compounds with potential varroacide activities

Pesticide Biochemistry and Physiology (2019)

160, 11-19

10.1016/J.PESTBP.2019.05.012

Gozzi, Gustavo J. and Gonzalez, Daniel and Boudesco, Christophe and Dias, Alexandre M. M. and Gotthard, Guillaume and Uyanik, Burhan and Dondaine, Lucile and Marcion, Guillaume and Hermetet, François and Denis, Camille and Hardy, Laurianne and Suzanne, Peggy and Douhard, Romain and Jego, Gaetan and Dubrez, Laurence and Demidov, Oleg N. and Neiers, Fabrice and Briand, Loïc and Sopková-de Oliveira Santos, Jana and Voisin-Chiret, Anne-Sophie and Garrido, Carmen

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

Cell Death & Differentiation (2020)

27, 117-129

10.1038/S41418-019-0343-4

Gilson, Pauline and Couvet, Morgane and Vanwonterghem, Laetitia and Henry, Maxime and Vollaire, Julien and Baulin, Vladimir and Werner, Marco and Orlowska, Anna and Josserand, Véronique and Mahuteau-Betzer, Florence and Lafanechère, Laurence and Coll, Jean-Luc and Busser, Benoit and Hurbin, Amandine

The pyrrolopyrimidine colchicine-binding site agent PP-13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo

Biochemical Pharmacology (2019)

160, 1-13

10.1016/J.BCP.2018.12.004

Mokrani, El Hassen and Bensegueni, Abderrahmane and Chaput, Ludovic and Beauvineau, Claire and Djeghim, Hanane and Mouawad, Liliane

Identification of New Potent Acetylcholinesterase Inhibitors Using Virtual Screening and in vitro Approaches

Molecular Informatics (2019)

38,

10.1002/MINF.201800118

Küssau, Tanja and Van Wyk, Niël and Johansen, Matt D. and Alsarraf, Husam M. A. B. and Neyret, Aymeric and Hamela, Claire and Sørensen, Kasper K. and Thygesen, Mikkel B. and Beauvineau, Claire and Kremer, Laurent and Blaise, Mickaël

Functional Characterization of the N-Acetylmuramyl-l-Alanine Amidase, Ami1, from Mycobacterium abscessus

Cells (2020)

9, 2410

10.3390/CELLS9112410

Pechalrieu, Dany and Dauzonne, Daniel and Arimondo, Paola B. and Lopez, Marie

Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells

European Journal of Medicinal Chemistry (2020)

186, 111829

10.1016/J.EJMECH.2019.111829

Gory-Fauré, Sylvie and Powell, Rebecca and Jonckheere, Julie and Lanté, Fabien and Denarier, Eric and Peris, Leticia and Nguyen, Chi Hung and Buisson, Alain and Lafanechère, Laurence and Andrieux, Annie

Pyr1-Mediated Pharmacological Inhibition of LIM Kinase Restores Synaptic Plasticity and Normal Behavior in a Mouse Model of Schizophrenia

Frontiers in Pharmacology (2021)

12,

10.3389/FPHAR.2021.627995

Knudsen Dal, Nils-Jørgen and Speth, Martin and Johann, Kerstin and Barz, Matthias and Beauvineau, Claire and Wohlmann, Jens and Fenaroli, Federico and Gicquel, Brigitte and Griffiths, Gareth and Alonso-Rodriguez, Noelia

The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds

Disease Models & Mechanisms (2022)

15,

10.1242/DMM.049147

Lapaillerie, Delphine and Charlier, Cathy and Guyonnet-Dupérat, Véronique and Murigneux, Emilie and Fernandes, Henrique S. and Martins, Fábio G. and Magalhães, Rita P. and Vieira, Tatiana F. and Richetta, Clémence and Subra, Frédéric and Lebourgeois, Samuel and Charpentier, Charlotte and Descamps, Diane and Visseaux, Benoît and Weigel, Pierre and Favereaux, Alexandre and Beauvineau, Claire and Buron, Frédéric and Teulade-Fichou, Marie-Paule and Routier, Sylvain and Gallois-Montbrun, Sarah and Meertens, Laurent and Delelis, Olivier and Sousa, Sérgio F. and Parissi, Vincent

Selection of Bis-Indolyl Pyridines and Triphenylamines as New Inhibitors of SARS-CoV-2 Cellular Entry by Modulating the Spike Protein/ACE2 Interfaces

Antimicrobial Agents and Chemotherapy (2022)

66,

10.1128/AAC.00083-22

Cioetto-Mazzabò, Laura and Boldrin, Francesca and Beauvineau, Claire and Speth, Martin and Marina, Alberto and Namouchi, Amine and Segafreddo, Greta and Cimino, Mena and Favre-Rochex, Sandrine and Balasingham, Seetha and Trastoy, Beatriz and Munier-Lehmann, Hélène and Griffiths, Gareth and Gicquel, Brigitte and Guerin, Marcelo E and Manganelli, Riccardo and Alonso-Rodríguez, Noelia

SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression

Nucleic Acids Research (2023)

51, 144-165

10.1093/NAR/GKAC1173

Verrelle, Pierre and Gestraud, Pierre and Poyer, Florent and Soria, Adèle and Tessier, Sarah and Lescure, Aurianne and Anthony, Elodie and Corbé, Maxime and Heinrich, Sophie and Beauvineau, Claire and Chaput, Ludovic and Granzhan, Anton and Piguel, Sandrine and Perez, Franck and Teulade-Fichou, Marie-Paule and Megnin-Chanet, Frédérique and Del Nery, Elaine

Integrated High-Throughput Screening and Large-Scale Isobolographic Analysis to Accelerate the Discovery of Radiosensitizers With Greater Selectivity for Cancer Cells

International Journal of Radiation Oncology*Biology*Physics (2024)

118, 1294-1307

10.1016/J.IJROBP.2023.09.044

Berthonneau, Clément and Nun, Pierrick and Rivière, Matthieu and Pauvert, Mickael and Dénès, Fabrice and Lebreton, Jacques

Hemisynthesis of 2,3,4-13C3-1,4-Androstadien-3,17-dione: A Key Precursor for the Synthesis of 13C3-Androstanes and 13C3-Estranes

The Journal of Organic Chemistry (2018)

83, 3727-3737

10.1021/ACS.JOC.7B03216

Patin, Justine and Castro, Claire and Steenman, Marja and Hivonnait, Agnès and Carcouët, Agnès and Tessier, Arnaud and Lebreton, Jacques and Bihouée, Audrey and Donnart, Audrey and Le Marec, Hervé and Baró, Isabelle and Charpentier, Flavien and Derangeon, Mickaël

Gap-134, a Connexin43 activator, prevents age-related development of ventricular fibrosis in Scn5a-mice

Pharmacological Research (2020)

159, 104922

10.1016/J.PHRS.2020.104922

Vereshchuk, Nataliia and Matheu, Roc and Benet-Buchholz, Jordi and Pipelier, Muriel and Lebreton, Jacques and Dubreuil, Didier and Tessier, Arnaud and Gimbert-Suriñach, Carolina and Ertem, Mehmed Z. and Llobet, Antoni

Second Coordination Sphere Effects in an Evolved Ru Complex Based on Highly Adaptable Ligand Results in Rapid Water Oxidation Catalysis

Journal of the American Chemical Society (2020)

142, 5068-5077

10.1021/JACS.9B11935

Taillebois, Emiliane and Cartereau, Alison and Graton, Jérôme and Le Questel, Jean-Yves and Lebreton, Jacques and Mathé-Allainmat, Monique and Thany, Steeve H.

Synergic effect of a quinuclidine benzamide complexed with borane, the LMA10233, in combination with seven pesticides

Pesticide Biochemistry and Physiology (2020)

168, 104633

10.1016/J.PESTBP.2020.104633

Dupas, Thomas and Denis, Manon and Dontaine, Justine and Persello, Antoine and Bultot, Laurent and Erraud, Angélique and Vertommen, Didier and Bouchard, Bertrand and Tessier, Arnaud and Rivière, Matthieu and Lebreton, Jacques and Bigot-Corbel, Edith and Montnach, Jérôme and De Waard, Michel and Gauthier, Chantal and Burelle, Yan and Olson, Aaron K. and Rozec, Bertrand and Des Rosiers, Christine and Bertrand, Luc and Issad, Tarik and Lauzier, Benjamin

Protein O-GlcNAcylation levels are regulated independently of dietary intake in a tissue and time-specific manner during rat postnatal development

Acta Physiologica (2021)

231,

10.1111/APHA.13566

Denis, Manon and Dupas, Thomas and Persello, Antoine and Dontaine, Justine and Bultot, Laurent and Betus, Charlotte and Pelé, Thomas and Dhot, Justine and Erraud, Angélique and Maillard, Anaïs and Montnach, Jérôme and Leroux, Aurélia A. and Bigot-Corbel, Edith and Vertommen, Didier and Rivière, Matthieu and Lebreton, Jacques and Tessier, Arnaud and Waard, Michel De and Bertrand, Luc and Rozec, Bertrand and Lauzier, Benjamin

An O-GlcNAcylomic Approach Reveals ACLY as a Potential Target in Sepsis in the Young Rat

International Journal of Molecular Sciences (2021)

22, 9236

10.3390/IJMS22179236

Smadja, Jimmy and Quéméner, Agnès and Maillasson, Mike and Sicard, Benoit and Leray, Aurélien and Arzel, Laurence and Lebreton, Jacques and Mortier, Erwan and Dubreuil, Didier and Mathé-Allainmat, Monique

Rational modification, synthesis and biological evaluation of N-substituted phthalazinone derivatives designed to target interleukine-15 protein

Bioorganic & Medicinal Chemistry (2021)

39, 116161

10.1016/J.BMC.2021.116161

Danieau, Geoffroy and Morice, Sarah and Renault, Sarah and Brion, Régis and Biteau, Kevin and Amiaud, Jérôme and Cadé, Marie and Heymann, Dominique and Lézot, Frédéric and Verrecchia, Franck and Rédini, Françoise and Brounais-Le Royer, Bénédicte

ICG-001, an Inhibitor of the ß-Catenin and cAMP Response Element-Binding Protein Dependent Gene Transcription, Decreases Proliferation but Enhances Migration of Osteosarcoma Cells

Pharmaceuticals (2021)

14, 421

10.3390/PH14050421

Cariou, Ronan and Rivière, Matthieu and Hutinet, Sébastien and Tebbaa, Asmaa and Dubreuil, Didier and Mathé-Allainmat, Monique and Lebreton, Jacques and Le Bizec, Bruno and Tessier, Arnaud and Dervilly, Gaud

Thorough investigation of non-volatile substances extractible from inner coatings of metallic cans and their occurrence in the canned vegetables

Journal of Hazardous Materials (2022)

435, 129026

10.1016/J.JHAZMAT.2022.129026

Erraud, Angelique and Dupas, Thomas and Manon, Denis and Betus, Charlotte and Bultot, Laurent and Rivière, Matthieu and Lebreton, Jacques and Tessier, Arnaud and De Waard, Michel and Bertrand, Luc and Rozec, Bertrand and Lauzier, Benjamin

ATP-CITRATE LYASE expression and activity are modulated by O-GlcNAc levels

Archives of Cardiovascular Diseases Supplements (2023)

15, 241

10.1016/J.ACVDSP.2023.03.138

Lagneau, N. and Terriac, L. and Tournier, P. and Helesbeux, J-J. and Viault, G. and Séraphin, D. and Halgand, B. and Loll, F. and Garnier, C. and Jonchère, C. and Rivière, M. and Tessier, A. and Lebreton, J. and Maugars, Y. and Guicheux, J. and Le Visage, C. and Delplace, V.

A new boronate ester-based crosslinking strategy allows the design of nonswelling and long-term stable dynamic covalent hydrogels

Biomaterials Science (2023)

11, 2033-2045

10.1039/D2BM01690G

Foret-Lucas, Charlotte and Figueroa, Thomas and Bertin, Alexandre and Bessière, Pierre and Lucas, Alexandre and Bergonnier, Dorian and Wasniewski, Marine and Servat, Alexandre and Tessier, Arnaud and Lezoualc'h, Frank and Volmer, Romain

EPAC1 Pharmacological Inhibition with AM-001 Prevents SARS-CoV-2 and Influenza A Virus Replication in Cells

Viruses (2023)

15, 319

10.3390/V15020319

Mier, Nataly Carolina and Roper, Donald Keith

Effects of an indole derivative on cell proliferation, transfection, and alternative splicing in production of lentiviral vectors by transient co-transfection

PLOS ONE (2024)

19, e0297817

10.1371/JOURNAL.PONE.0297817

Demeyer, Alexandre and Fonteneau, Lucie and Liennard, Marion and Foyer, Claire and Weigel, Pierre and Laurent, Adèle D. and Lebreton, Jacques and Fleury, Fabrice and Mathé-Allainmat, Monique

Synthesis and biological evaluation of DIDS analogues as efficient inhibitors of RAD51 involved in homologous recombination

Bioorganic & Medicinal Chemistry Letters (2023)

87, 129261

10.1016/J.BMCL.2023.129261

Dupas, Thomas and Vergnaud, Amandine and Pelé, Thomas and Blangy-Letheule, Angélique and Aillerie, Virginie and Bouaud, Martin and Erraud, Angélique and Maillard, Anaïs and Hassoun, Dorian and Persello, Antoine and Lecomte, Jules and Rivière, Matthieu and Tessier, Arnaud and Leroux, Aurélia A. and Rozec, Bertrand and Denis, Manon and Lauzier, Benjamin

O-GlcNAcylation levels remain stable regardless of the anaesthesia in healthy rats

Scientific Reports (2024)

14,

10.1038/S41598-024-61445-0

Rupérez, David and Rivière, Matthieu and Lebreton, Jacques and Aznar, Margarita and Silva, Filomena and Tessier, Arnaud and Cariou, Ronan and Nerín, Cristina

Synthesis and quantification of oligoesters migrating from starch-based food packaging materials

Journal of Hazardous Materials (2024)

476, 135202

10.1016/J.JHAZMAT.2024.135202

Pomel, Sébastien and Cojean, Sandrine and Pons, Valérie and Cintrat, Jean-Christophe and Nguyen, Laetitia and Vacus, Joël and Pruvost, Alain and Barbier, Julien and Gillet, Daniel and Loiseau, Philippe M

An adamantamine derivative as a drug candidate for the treatment of visceral leishmaniasis

Journal of Antimicrobial Chemotherapy (2021)

76, 2640-2650

10.1093/JAC/DKAB226

Laporte, Manon and Jochmans, Dirk and Bardiot, Dorothée and Desmarets, Lowiese and Debski-Antoniak, Oliver J. and Mizzon, Giulia and Abdelnabi, Rana and Leyssen, Pieter and Chiu, Winston and Zhang, Zhikuan and Nomura, Norimichi and Boland, Sandro and Ohto, Umeharu and Stahl, Yannick and Wuyts, Jurgen and De Jonghe, Steven and Stevaert, Annelies and van Hemert, Martijn J. and Bontes, Brenda W. and Wanningen, Patrick and Groenewold, G. J. Mirjam and Zegar, Aneta and Owczarek, Katarzyna and Joshi, Sanjata and Koukni, Mohamed and Arzel, Philippe and Klaassen, Hugo and Vanherck, Jean-Christophe and Vandecaetsbeek, Ilse and Cremers, Niels and Donckers, Kim and Francken, Thibault and Van Buyten, Tina and Rymenants, Jasper and Schepers, Joost and Pyrc, Krzysztof and Hilgenfeld, Rolf and Dubuisson, Jean and Bosch, Berend-Jan and Van Kuppeveld, Frank and Eydoux, Cecilia and Decroly, Etienne and Canard, Bruno and Naesens, Lieve and Weynand, Birgit and Snijder, Eric J. and Belouzard, Sandrine and Shimizu, Toshiyuki and Bartenschlager, Ralf and Hurdiss, Daniel L. and Marchand, Arnaud and Chaltin, Patrick and Neyts, Johan

A coronavirus assembly inhibitor that targets the viral membrane protein

Nature (2025)

640, 514-523

10.1038/S41586-025-08773-X

Feracci, Mikael and Eydoux, Cécilia and Fattorini, Véronique and Lo Bello, Lea and Gauffre, Pierre and Selisko, Barbara and Sutto-Ortiz, Priscila and Shannon, Ashleigh and Xia, Hongjie and Shi, Pei-Yong and Noel, Mathieu and Debart, Françoise and Vasseur, Jean-Jacques and Good, Steve and Lin, Kai and Moussa, Adel and Sommadossi, Jean-Pierre and Chazot, Aurélie and Alvarez, Karine and Guillemot, Jean-Claude and Decroly, Etienne and Ferron, François and Canard, Bruno

AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5

Antiviral Research (2023)

212, 105574

10.1016/J.ANTIVIRAL.2023.105574

Savary, Clara and Luciana, Léa and Huchedé, Paul and Tourbez, Arthur and Coquet, Claire and Broustal, Maëlle and Lopez Gonzalez, Alejandro and Deligne, Clémence and Diot, Thomas and Naret, Olivier and Costa, Mariana and Meynard, Nina and Barbet, Virginie and Müller, Kevin and Tonon, Laurie and Gadot, Nicolas and Degletagne, Cyril and Attignon, Valéry and Léon, Sophie and Vanbelle, Christophe and Bomane, Alexandra and Rochet, Isabelle and Mournetas, Virginie and Oliveira, Luciana and Rinaudo, Paul and Bergeron, Christophe and Dutour, Aurélie and Cordier-Bussat, Martine and Roch, Aline and Brandenberg, Nathalie and El Zein, Sophie and Watson, Sarah and Orbach, Daniel and Delattre, Olivier and Dijoud, Frédérique and Corradini, Nadège and Picard, Cécile and Maucort-Boulch, Delphine and Le Grand, Marion and Pasquier, Eddy and Blay, Jean-Yves and Castets, Marie and Broutier, Laura

Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers

Cell Reports Medicine (2023)

4, 101339

10.1016/J.XCRM.2023.101339

Ariey-Bonnet, Jérémy and Berges, Raphael and Montero, Marie-Pierre and Mouysset, Baptiste and Piris, Patricia and Muller, Kevin and Pinna, Guillaume and Failes, Tim W. and Arndt, Greg M. and Morando, Philippe and Baeza-Kallee, Nathalie and Colin, Carole and Chinot, Olivier and Braguer, Diane and Morelli, Xavier and André, Nicolas and Carré, Manon and Tabouret, Emeline and Figarella-Branger, Dominique and Le Grand, Marion and Pasquier, Eddy

Combination drug screen targeting glioblastoma core vulnerabilities reveals pharmacological synergisms

eBioMedicine (2023)

95, 104752

10.1016/J.EBIOM.2023.104752

De Castro, Sonia and Stevaert, Annelies and Maldonado, Miguel and Delpal, Adrien and Vandeput, Julie and Van Loy, Benjamin and Eydoux, Cecilia and Guillemot, Jean-Claude and Decroly, Etienne and Gago, Federico and Canard, Bruno and Camarasa, Maria-Jose and Velázquez, Sonsoles and Naesens, Lieve

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

Pharmaceuticals (2022)

15, 1021

10.3390/PH15081021

Bardiot, Dorothée and Vangeel, Laura and Koukni, Mohamed and Arzel, Philippe and Zwaagstra, Marleen and Lyoo, Heyrhyoung and Wanningen, Patrick and Ahmad, Shamshad and Zhang, Linlin and Sun, Xinyuanyuan and Delpal, Adrien and Eydoux, Cecilia and Guillemot, Jean-Claude and Lescrinier, Eveline and Klaassen, Hugo and Leyssen, Pieter and Jochmans, Dirk and Castermans, Karolien and Hilgenfeld, Rolf and Robinson, Colin and Decroly, Etienne and Canard, Bruno and Snijder, Eric J. and van Hemert, Martijn J. and van Kuppeveld, Frank and Chaltin, Patrick and Neyts, Johan and De Jonghe, Steven and Marchand, Arnaud

Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

Molecules (2022)

27, 1052

10.3390/MOLECULES27031052

Shannon, Ashleigh and Fattorini, Véronique and Sama, Bhawna and Selisko, Barbara and Feracci, Mikael and Falcou, Camille and Gauffre, Pierre and El Kazzi, Priscila and Delpal, Adrien and Decroly, Etienne and Alvarez, Karine and Eydoux, Cécilia and Guillemot, Jean-Claude and Moussa, Adel and Good, Steven S. and La Colla, Paolo and Lin, Kai and Sommadossi, Jean-Pierre and Zhu, Yingxiao and Yan, Xiaodong and Shi, Hui and Ferron, François and Canard, Bruno

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Nature Communications (2022)

13,

10.1038/S41467-022-28113-1

Vicenti, Ilaria and Martina, Maria Grazia and Boccuto, Adele and De Angelis, Marta and Giavarini, Giorgia and Dragoni, Filippo and Marchi, Serena and Trombetta, Claudia Maria and Crespan, Emmanuele and Maga, Giovanni and Eydoux, Cecilia and Decroly, Etienne and Montomoli, Emanuele and Nencioni, Lucia and Zazzi, Maurizio and Radi, Marco

System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2

European Journal of Medicinal Chemistry (2021)

224, 113683

10.1016/J.EJMECH.2021.113683

Lo, Ho Sing and Hui, Kenrie Pui Yan and Lai, Hei-Ming and He, Xu and Khan, Khadija Shahed and Kaur, Simranjeet and Huang, Junzhe and Li, Zhongqi and Chan, Anthony K. N. and Cheung, Hayley Hei-Yin and Ng, Ka-Chun and Ho, John Chi Wang and Chen, Yu Wai and Ma, Bowen and Cheung, Peter Man-Hin and Shin, Donghyuk and Wang, Kaidao and Lee, Meng-Hsuan and Selisko, Barbara and Eydoux, Cecilia and Guillemot, Jean-Claude and Canard, Bruno and Wu, Kuen-Phon and Liang, Po-Huang and Dikic, Ivan and Zuo, Zhong and Chan, Francis K. L. and Hui, David S. C. and Mok, Vincent C. T. and Wong, Kam-Bo and Mok, Chris Ka Pun and Ko, Ho and Aik, Wei Shen and Chan, Michael Chi Wai and Ng, Wai-Lung

Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

ACS Central Science (2021)

7, 792-802

10.1021/ACSCENTSCI.0C01186

Peyrat, Laure-Anne and Eparvier, Véronique and Eydoux, Cécilia and Guillemot, Jean-Claude and Litaudon, Marc and Stien, Didier

Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Journal of Natural Products (2020)

83, 2330-2336

10.1021/ACS.JNATPROD.9B01169

Shannon, Ashleigh and Le, Nhung Thi-Tuyet and Selisko, Barbara and Eydoux, Cecilia and Alvarez, Karine and Guillemot, Jean-Claude and Decroly, Etienne and Peersen, Olve and Ferron, Francois and Canard, Bruno

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

Antiviral Research (2020)

178, 104793

10.1016/J.ANTIVIRAL.2020.104793

Quintana, V.M. and Selisko, B. and Brunetti, J.E. and Eydoux, C. and Guillemot, J.C. and Canard, B. and Damonte, E.B. and Julander, J.G. and Castilla, V.

Antiviral activity of the natural alkaloid anisomycin against dengue and Zika viruses

Antiviral Research (2020)

176, 104749

10.1016/J.ANTIVIRAL.2020.104749

Ariey-Bonnet, Jeremy and Carrasco, Kendall and Le Grand, Marion and Hoffer, Laurent and Betzi, Stéphane and Feracci, Mikael and Tsvetkov, Philipp and Devred, Francois and Collette, Yves and Morelli, Xavier and Ballester, Pedro and Pasquier, Eddy

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

Molecular Oncology (2020)

14, 3083-3099

10.1002/1878-0261.12810

Ferreira-Ramos, Ana S. and Li, Changqing and Eydoux, Cécilia and Contreras, Jean Marie and Morice, Christophe and Quérat, Gilles and Gigante, Alba and Pérez Pérez, María-Jesús and Jung, Marie-Louise and Canard, Bruno and Guillemot, Jean-Claude and Decroly, Etienne and Coutard, Bruno

Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay

Antiviral Research (2019)

163, 59-69

10.1016/J.ANTIVIRAL.2019.01.003

Halby, Ludovic and Marechal, Nils and Pechalrieu, Dany and Cura, Vincent and Franchini, Don-Marc and Faux, Céline and Alby, Fréderic and Troffer-Charlier, Nathalie and Kudithipudi, Srikanth and Jeltsch, Albert and Aouadi, Wahiba and Decroly, Etienne and Guillemot, Jean-Claude and Page, Patrick and Ferroud, Clotilde and Bonnefond, Luc and Guianvarc'h, Dominique and Cavarelli, Jean and Arimondo, Paola B.

Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

Philosophical Transactions of the Royal Society B: Biological Sciences (2018)

373, 20170072

10.1098/RSTB.2017.0072

Taïeb, David and Jha, Abhishek and Guerin, Carole and Pang, Ying and Adams, Karen T and Chen, Clara C and Romanet, Pauline and Roche, Philippe and Essamet, Wassim and Ling, Alexander and Quezado, Martha M and Castinetti, Frédéric and Sebag, Fréderic and Pacak, Karel

18F-FDOPA PET/CT Imaging of MAX-Related Pheochromocytoma

The Journal of Clinical Endocrinology & Metabolism (2018)

103, 1574-1582

1510.1210/JC.2017-02324

Gómez-SanJuan, Asier and Gamo, Ana-María and Delang, Leen and Pérez-Sánchez, Alfonso and Amrun, Siti Naqiah and Abdelnabi, Rana and Jacobs, Sofie and Priego, Eva-María and Camarasa, María-José and Jochmans, Dirk and Leyssen, Pieter and Ng, Lisa F. P. and Querat, Gilles and Neyts, Johan and Pérez-Pérez, María-Jesús

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones

ACS Infectious Diseases (2018)

4, 605-619

10.1021/ACSINFECDIS.7B00219

Cannalire, Rolando and Tarantino, Delia and Astolfi, Andrea and Barreca, Maria Letizia and Sabatini, Stefano and Massari, Serena and Tabarrini, Oriana and Milani, Mario and Querat, Gilles and Mastrangelo, Eloise and Manfroni, Giuseppe and Cecchetti, Violetta

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase

European Journal of Medicinal Chemistry (2018)

143, 1667-1676

10.1016/J.EJMECH.2017.10.064

Touret, Franck and Baronti, Cécile and Goethals, Olivia and Van Loock, Marnix and de Lamballerie, Xavier and Querat, Gilles

Phylogenetically based establishment of a dengue virus panel, representing all available genotypes, as a tool in dengue drug discovery

Antiviral Research (2019)

168, 109-113

10.1016/J.ANTIVIRAL.2019.05.005

Cannalire, Rolando and Tarantino, Delia and Piorkowski, Geraldine and Carletti, Tea and Massari, Serena and Felicetti, Tommaso and Barreca, Maria Letizia and Sabatini, Stefano and Tabarrini, Oriana and Marcello, Alessandro and Milani, Mario and Cecchetti, Violetta and Mastrangelo, Eloise and Manfroni, Giuseppe and Querat, Gilles

Broad spectrum anti-flavivirus pyridobenzothiazolones leading to less infective virions

Antiviral Research (2019)

167, 6-12

10.1016/J.ANTIVIRAL.2019.03.004

Rabah, Nadia and Ortega Granda, Oney and Quérat, Gilles and Canard, Bruno and Decroly, Etienne and Coutard, Bruno

Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Antiviral Research (2020)

182, 104883

10.1016/J.ANTIVIRAL.2020.104883

Abdelnabi, Rana and Kovacikova, Kristina and Moesslacher, Julia and Donckers, Kim and Battisti, Verena and Leyssen, Pieter and Langer, Thierry and Puerstinger, Gerhard and Quérat, Gilles and Li, Changqing and Decroly, Etienne and Tas, Ali and Marchand, Arnaud and Chaltin, Patrick and Coutard, Bruno and van Hemert, Martijn and Neyts, Johan and Delang, Leen

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

Antimicrobial Agents and Chemotherapy (2020)

64,

10.1128/AAC.00649-20

Shannon, Ashleigh and Selisko, Barbara and Le, Nhung-Thi-Tuyet and Huchting, Johanna and Touret, Franck and Piorkowski, Géraldine and Fattorini, Véronique and Ferron, François and Decroly, Etienne and Meier, Chris and Coutard, Bruno and Peersen, Olve and Canard, Bruno

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Nature Communications (2020)

11,

10.1038/S41467-020-18463-Z

Touret, Franck and Gilles, Magali and Barral, Karine and Nougairède, Antoine and van Helden, Jacques and Decroly, Etienne and de Lamballerie, Xavier and Coutard, Bruno

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

Scientific Reports (2020)

10,

10.1038/S41598-020-70143-6

Touret, Franck and Gilles, Magali and Klitting, Raphaelle and Aubry, Fabien and de Lamballerie, Xavier and Nougairède, Antoine

Live Zika virus chimeric vaccine candidate based on a yellow fever 17-D attenuated backbone

Emerging Microbes & Infections (2018)

7, 1-12

10.1038/S41426-018-0161-7

Pastorino, Boris and Touret, Franck and Gilles, Magali and de Lamballerie, Xavier and Charrel, Rémi N.

Prolonged Infectivity of SARS-CoV-2 in Fomites

Emerging Infectious Diseases (2020)

26, 2256-2257

10.3201/EID2609.201788

Pastorino, Boris and Touret, Franck and Gilles, Magali and Luciani, Lea and de Lamballerie, Xavier and Charrel, Remi N.

Evaluation of Chemical Protocols for Inactivating SARS-CoV-2 Infectious Samples

Viruses (2020)

12, 624

10.3390/V12060624

Pastorino, Boris and Touret, Franck and Gilles, Magali and de Lamballerie, Xavier and Charrel, Remi N.

Heat Inactivation of Different Types of SARS-CoV-2 Samples: What Protocols for Biosafety, Molecular Detection and Serological Diagnostics?

Viruses (2020)

12, 735

10.3390/V12070735

Maisonnasse, Pauline and Guedj, Jérémie and Contreras, Vanessa and Behillil, Sylvie and Solas, Caroline and Marlin, Romain and Naninck, Thibaut and Pizzorno, Andres and Lemaitre, Julien and Gonçalves, Antonio and Kahlaoui, Nidhal and Terrier, Olivier and Fang, Raphael Ho Tsong and Enouf, Vincent and Dereuddre-Bosquet, Nathalie and Brisebarre, Angela and Touret, Franck and Chapon, Catherine and Hoen, Bruno and Lina, Bruno and Calatrava, Manuel Rosa and van der Werf, Sylvie and de Lamballerie, Xavier and Le Grand, Roger

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

Nature (2020)

585, 584-587

10.1038/S41586-020-2558-4

Cochin, Maxime and Luciani, Léa and Touret, Franck and Driouich, Jean-Sélim and Petit, Paul-Rémi and Moureau, Grégory and Baronti, Cécile and Laprie, Caroline and Thirion, Laurence and Maes, Piet and Boudewijns, Robbert and Neyts, Johan and de Lamballerie, Xavier and Nougairède, Antoine

The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model

Communications Biology (2022)

5,

10.1038/S42003-022-03171-9

Lamiable, Alexis and Champetier, Tiphaine and Leonardi, Francesco and Cohen, Ethan and Sommer, Peter and Hardy, David and Argy, Nicolas and Massougbodji, Achille and Del Nery, Elaine and Cottrell, Gilles and Kwon, Yong-Jun and Genovesio, Auguste

Revealing invisible cell phenotypes with conditional generative modeling

Nature Communications (2023)

14,

10.1038/S41467-023-42124-6

Decroocq, Justine and Birsen, Rudy and Montersino, Camille and Chaskar, Prasad and Mano, Jordi and Poulain, Laury and Friedrich, Chloe and Alary, Anne-Sophie and Guermouche, Helene and Sahal, Ambrine and Fouquet, Guillemette and Gotanègre, Mathilde and Simonetta, Federico and Mouche, Sarah and Gestraud, Pierre and Lescure, Auriane and Del Nery, Elaine and Bosc, Claudie and Grenier, Adrien and Mazed, Fetta and Mondesir, Johanna and Chapuis, Nicolas and Ho, Liza and Boughalem, Aicha and Lelorc'h, Marc and Gobeaux, Camille and Fontenay, Michaela and Recher, Christian and Vey, Norbert and Guillé, Arnaud and Birnbaum, Daniel and Hermine, Olivier and Radford-Weiss, Isabelle and Tsantoulis, Petros and Collette, Yves and Castellano, Rémy and Sarry, Jean-Emmanuel and Pasmant, Eric and Bouscary, Didier and Kosmider, Olivier and Tamburini, Jerome

RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia

Leukemia (2022)

36, 1237-1252

10.1038/S41375-022-01541-0

Garcia, Hugo and Serafin, Alice S. and Silbermann, Flora and Porée, Esther and Viau, Amandine and Mahaut, Clémentine and Billot, Katy and Birgy, Éléonore and Garfa-Traore, Meriem and Roy, Stéphanie and Ceccarelli, Salomé and Mehraz, Manon and Rodriguez, Pamela C. and Deleglise, Bérangère and Furio, Laetitia and Jabot-Hanin, Fabienne and Cagnard, Nicolas and Del Nery, Elaine and Fila, Marc and Sin-Monnot, Soraya and Antignac, Corinne and Lyonnet, Stanislas and Krug, Pauline and Salomon, Rémi and Annereau, Jean-Philippe and Benmerah, Alexandre and Delous, Marion and Briseño-Roa, Luis and Saunier, Sophie

Agonists of prostaglandin E 2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies

Proceedings of the National Academy of Sciences (2022)

119,

10.1073/PNAS.2115960119

Boncompain, Gaelle and Herit, Floriane and Tessier, Sarah and Lescure, Aurianne and Del Nery, Elaine and Gestraud, Pierre and Staropoli, Isabelle and Fukata, Yuko and Fukata, Masaki and Brelot, Anne and Niedergang, Florence and Perez, Franck

Targeting CCR5 trafficking to inhibit HIV-1 infection

Science Advances (2019)

5,

10.1126/SCIADV.AAX0821

Lesage, Sarah and Chazal, Maxime and Beauclair, Guillaume and Batalie, Damien and Cerboni, Silvia and Couderc, Elodie and Lescure, Aurianne and Del Nery, Elaine and Tangy, Frédéric and Martin, Annette and Manel, Nicolas and Jouvenet, Nolwenn

Discovery of Genes that Modulate Flavivirus Replication in an Interferon-Dependent Manner

Journal of Molecular Biology (2022)

434, 167277

10.1016/J.JMB.2021.167277

Fevre, Romain and Mary, Gaëtan and Vertti-Quintero, Nadia and Durand, Aude and Tomasi, Raphaël F.-X. and Del Nery, Elaine and Baroud, Charles N.

Combinatorial drug screening on 3D Ewing sarcoma spheroids using droplet-based microfluidics

iScience (2023)

26, 106651

10.1016/J.ISCI.2023.106651

Chabot, Thomas and Nemati, Fariba and Herbette, Aurélie and Demeyer, Alexandre and Dayot, Stéphane and Ganier, Olivier and Alsafadi, Samar and Gardrat, Sophie and Mariani, Pascale and Luporsi, Marie and Corbé, Maxime and Servois, Vincent and Cassoux, Nathalie and Decaudin, Didier and Roman, Sergio Roman and Del Nery, Elaine and Piperno-Neumann, Sophie and Stern, Marc-Henri and Rodrigues, Manuel

Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency

npj Precision Oncology (2022)

6,

10.1038/S41698-022-00326-Z

Kozik, Patrycja and Gros, Marine and Itzhak, Daniel N. and Joannas, Leonel and Heurtebise-Chrétien, Sandrine and Krawczyk, Patrycja A. and Rodríguez-Silvestre, Pablo and Alloatti, Andrés and Magalhaes, Joao Gamelas and Del Nery, Elaine and Borner, Georg H.H. and Amigorena, Sebastian

Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity

Cell Reports (2020)

32, 107905

10.1016/J.CELREP.2020.107905

Rose, France and Basu, Sreetama and Rexhepaj, Elton and Chauchereau, Anne and Del Nery, Elaine and Genovesio, Auguste

Compound Functional Prediction Using Multiple Unrelated Morphological Profiling Assays

SLAS Technology (2018)

23, 243-251

10.1177/2472630317740831

Laplantine, Emmanuel and Chable-Bessia, Christine and Oudin, Anne and Swain, Jitendryia and Soria, Adèle and Merida, Peggy and Gourdelier, Manon and Mestiri, Sarra and Besseghe, Indira and Bremaud, Erwan and Neyret, Aymeric and Lyonnais, Sebastien and Favard, Cyril and Benaroch, Philippe and Hubert, Mathieu and Schwartz, Olivier and Guerin, Maryse and Danckaert, Anne and Del Nery, Elaine and Muriaux, Delphine and Weil, Robert

The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-kappaB signaling

iScience (2022)

25, 105066

10.1016/J.ISCI.2022.105066

Olivon, Florent and Nothias, Louis-Félix and Dumontet, Vincent and Retailleau, Pascal and Berger, Sylvie and Ferry, Gilles and Cohen, William and Pfeiffer, Bruno and Boutin, Jean A. and Scalbert, Elisabeth and Roussi, Fanny and Litaudon, Marc

Natural Inhibitors of the RhoA-p115 Complex from the Bark ofMeiogyne baillonii

Journal of Natural Products (2018)

81, 1610-1618

10.1021/ACS.JNATPROD.8B00209

Petit, Bastien and Marguerite, Elodie and Van Elslande, Elsa and Nedev, Hristo and Iorga, Bogdan I. and Pham, Van Cuong and Doan, Thi Mai Huong and Séron, Karin and Litaudon, Marc and El Kalamouni, Chaker and Apel, Cécile

Antiviral miliusanes and isolation of an unprecedented miliusane dimer from Miliusa balansae

Fitoterapia (2024)

177, 106083

10.1016/J.FITOTE.2024.106083

Nothias-Esposito, Mélissa and Nothias, Louis Felix and Da Silva, Ricardo R. and Retailleau, Pascal and Zhang, Zheng and Leyssen, Pieter and Roussi, Fanny and Touboul, David and Paolini, Julien and Dorrestein, Pieter C. and Litaudon, Marc

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation

Journal of Natural Products (2019)

82, 1459-1470

10.1021/ACS.JNATPROD.8B00916

Chambon, Marion and Herrscher, Charline and Al Halabi, Dana and François, Nathan and Belouzard, Sandrine and Boutet, Stéphanie and Pham, Van Cuong and Doan, Thi Mai Huong and Séron, Karin and Mavingui, Patrick and Litaudon, Marc and El Kalamouni, Chaker and Apel, Cécile

New Phenolic Lipids from the Leaves of Clausena harmandiana Inhibit SARS-CoV-2 Entry into Host Cells

Molecules (2023)

28, 5414

10.3390/MOLECULES28145414

Chambaud, Marine and Le Ray, Anne-Marie and Hamzi, Racha and Charpentier, Thomas and Blon, Nadège and Bréard, Dimitri and Le Pogam, Pierre and Litaudon, Marc and Dumontet, Vincent and Bataillé-Simoneau, Nelly and Guillemette, Thomas and Simoneau, Philippe and Schinkovitz, Andreas and Guilet, David and Viault, Guillaume and Richomme, Pascal

Xanthone Inhibitors of Unfolded Protein Response Isolated from Calophyllum caledonicum

Journal of Natural Products (2024)

87, 1628-1634

10.1021/ACS.JNATPROD.4C00328

Remy, Simon and Solis, Deyvis and Silland, Pierre and Neyts, Johan and Roussi, Fanny and Touboul, David and Litaudon, Marc

Isolation of phenanthrenes and identification of phorbol ester derivatives as potential anti-CHIKV agents using FBMN and NAP from Sagotia racemosa

Phytochemistry (2019)

167, 112101

10.1016/J.PHYTOCHEM.2019.112101

Apel, Cécile and Bignon, Jérôme and Garcia-Alvarez, María Concepción and Ciccone, Sarah and Clerc, Patricia and Grondin, Isabelle and Girard-Valenciennes, Emmanuelle and Smadja, Jacqueline and Lopes, Philippe and Frédérich, Michel and Roussi, Fanny and Meinnel, Thierry and Giglione, Carmela and Litaudon, Marc

N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë

Fitoterapia (2018)

131, 91-95

10.1016/J.FITOTE.2018.10.014

Levaique, Hélène and Pamlard, Olivier and Apel, Cécile and Bignon, Jérôme and Arriola, Margaux and Kuhner, Robin and Awang, Khalijah and Loiseau, Philippe M. and Litaudon, Marc and Pomel, Sébastien

Alkyl-Resorcinol Derivatives as Inhibitors of GDP-Mannose Pyrophosphorylase with Antileishmanial Activities

Molecules (2021)

26, 1551

10.3390/MOLECULES26061551

Remy, Simon and Olivon, Florent and Desrat, Sandy and Blanchard, Florent and Eparvier, Véronique and Leyssen, Pieter and Neyts, Johan and Roussi, Fanny and Touboul, David and Litaudon, Marc

Structurally Diverse Diterpenoids from Sandwithia guyanensis

Journal of Natural Products (2018)

81, 901-912

10.1021/ACS.JNATPROD.7B01025

Sukumaran, S. Yaallini and Herrscher, Charline and Rasol, Nurulfazlina Edayah and Othman, Muhamad Aqmal and Liew, Sook Yee and Ismail, Nor Hadiani and Séron, Karin and Litaudon, Marc and Awang, Khalijah and El Kalamouni, Chaker and Apel, Cécile and Zahari, Azeana

Targeted Isolation of Antiviral Labdane Diterpenes from the Bark of Neo-uvaria foetida (Annonaceae) using LC-MS/MS-Based Molecular Networking

Journal of Natural Products (2024)

87, 1941-1951

10.1021/ACS.JNATPROD.4C00342

Olivon, Florent and Remy, Simon and Grelier, Gwendal and Apel, Cécile and Eydoux, Cécilia and Guillemot, Jean-Claude and Neyts, Johan and Delang, Leen and Touboul, David and Roussi, Fanny and Litaudon, Marc

Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

Journal of Natural Products (2019)

82, 330-340

10.1021/ACS.JNATPROD.8B00800

da Silva Figueiredo Celestino Gomes, Priscila and Da Silva, Franck and Bret, Guillaume and Rognan, Didier

Ranking docking poses by graph matching of protein-ligand interactions: lessons learned from the D3R Grand Challenge 2

Journal of Computer-Aided Molecular Design (2018)

32, 75-87

10.1007/S10822-017-0046-1

Da Silva, Franck and Desaphy, Jeremy and Rognan, Didier

IChem: A Versatile Toolkit for Detecting, Comparing, and Predicting Protein-Ligand Interactions

ChemMedChem (2018)

13, 507-510

10.1002/CMDC.201700505

Rivat, Cyril and Sar, Chamroeun and Mechaly, Ilana and Leyris, Jean-Philippe and Diouloufet, Lucie and Sonrier, Corinne and Philipson, Yann and Lucas, Olivier and Mallié, Sylvie and Jouvenel, Antoine and Tassou, Adrien and Haton, Henri and Venteo, Stéphanie and Pin, Jean-Philippe and Trinquet, Eric and Charrier-Savournin, Fabienne and Mezghrani, Alexandre and Joly, Willy and Mion, Julie and Schmitt, Martine and Pattyn, Alexandre and Marmigère, Frédéric and Sokoloff, Pierre and Carroll, Patrick and Rognan, Didier and Valmier, Jean

Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

Nature Communications (2018)

9,

10.1038/S41467-018-03496-2

Regenass, Pierre and Abboud, Dayana and Daubeuf, François and Lehalle, Christine and Gizzi, Patrick and Riché, Stéphanie and Hachet-Haas, Muriel and Rohmer, François and Gasparik, Vincent and Boeglin, Damien and Haiech, Jacques and Knehans, Tim and Rognan, Didier and Heissler, Denis and Marsol, Claire and Villa, Pascal and Galzi, Jean-Luc and Hibert, Marcel and Frossard, Nelly and Bonnet, Dominique

Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia

Journal of Medicinal Chemistry (2018)

61, 7671-7686

10.1021/ACS.JMEDCHEM.8B00657

Da Silva, Franck and Rognan, Didier

Structure-Based Detection of Orthosteric and Allosteric Pockets at Protein-Protein Interfaces

Methods in Molecular Biology (2018)

, 281-294

10.1007/978-1-4939-8639-2_8

Tran-Nguyen, Viet-Khoa and Da Silva, Franck and Bret, Guillaume and Rognan, Didier

All in One: Cavity Detection, Druggability Estimate, Cavity-Based Pharmacophore Perception, and Virtual Screening

Journal of Chemical Information and Modeling (2019)

59, 573-585

10.1021/ACS.JCIM.8B00684

Pes, Lara and Koester, Stephan David and Magnusson, Johannes Pall and Chercheja, Serghei and Medda, Federico and Abu Ajaj, Khalid and Rognan, Didier and Daum, Steffen and Nollmann, Friederike Inga and Garcia Fernandez, Javier and Perez Galan, Patricia and Walter, Heidi-Kristin and Warnecke, Anna and Kratz, Felix

Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Journal of Controlled Release (2019)

296, 81-92

10.1016/J.JCONREL.2019.01.010

Jacquemard, Célien and Tran-Nguyen, Viet-Khoa and Drwal, Malgorzata N. and Rognan, Didier and Kellenberger, Esther

Local Interaction Density (LID), a Fast and Efficient Tool to Prioritize Docking Poses

Molecules (2019)

24, 2610

10.3390/MOLECULES24142610

Koensgen, Florian and Da Silva, Franck and Rognan, Didier and Kellenberger, Esther

Unsupervised Classification of G-Protein Coupled Receptors and Their Conformational States Using IChem Intramolecular Interaction Patterns

Journal of Chemical Information and Modeling (2019)

59, 3611-3618

10.1021/ACS.JCIM.9B00054

Fremaux, Juliette and Venin, Claire and Mauran, Laura and Zimmer, Robert and Koensgen, Florian and Rognan, Didier and Bitsi, Stavroula and Lucey, Maria A. and Jones, Ben and Tomas, Alejandra and Guichard, Gilles and Goudreau, Sébastien R.

Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

Chemical Science (2019)

10, 9872-9879

10.1039/C9SC02079A

Da Silva, Franck and Bret, Guillaume and Teixeira, Leandro and Gonzalez, Claudio F. and Rognan, Didier

Exhaustive Repertoire of Druggable Cavities at Protein-Protein Interfaces of Known Three-Dimensional Structure

Journal of Medicinal Chemistry (2019)

62, 9732-9742

10.1021/ACS.JMEDCHEM.9B01184

Tran-Nguyen, Viet-Khoa and Jacquemard, Célien and Rognan, Didier

LIT-PCBA: An Unbiased Data Set for Machine Learning and Virtual Screening

Journal of Chemical Information and Modeling (2020)

60, 4263-4273

10.1021/ACS.JCIM.0C00155

Eguida, Merveille and Rognan, Didier

A Computer Vision Approach to Align and Compare Protein Cavities: Application to Fragment-Based Drug Design

Journal of Medicinal Chemistry (2020)

63, 7127-7142

10.1021/ACS.JMEDCHEM.0C00422

Tran-Nguyen, Viet-Khoa and Rognan, Didier

Benchmarking Data Sets from PubChem BioAssay Data: Current Scenario and Room for Improvement

International Journal of Molecular Sciences (2020)

21, 4380

10.3390/IJMS21124380

Bollenbach, Maud and Nemska, Simona and Wagner, Patrick and Camelin, Guillaume and Daubeuf, François and Obrecht, Adeline and Villa, Pascal and Rognan, Didier and Bihel, Frédéric and Bourguignon, Jean-Jacques and Schmitt, Martine and Frossard, Nelly

Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model

Molecules (2021)

26, 391

10.3390/MOLECULES26020391

Kuhaudomlarp, Sakonwan and Siebs, Eike and Shanina, Elena and Topin, Jérémie and Joachim, Ines and da Silva Figueiredo Celestino Gomes, Priscila and Varrot, Annabelle and Rognan, Didier and Rademacher, Christoph and Imberty, Anne and Titz, Alexander

Non-Carbohydrate Glycomimetics as Inhibitors of Calcium(II)-Binding Lectins

Angewandte Chemie International Edition (2021)

60, 8104-8114

10.1002/ANIE.202013217

Tran-Nguyen, Viet-Khoa and Bret, Guillaume and Rognan, Didier

True Accuracy of Fast Scoring Functions to Predict High-Throughput Screening Data from Docking Poses: The Simpler the Better

Journal of Chemical Information and Modeling (2021)

61, 2788-2797

10.1021/ACS.JCIM.1C00292

Eguida, Merveille and Rognan, Didier

Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision

Journal of Cheminformatics (2021)

13,

10.1186/S13321-021-00567-3

Siebs, Eike and Shanina, Elena and Kuhaudomlarp, Sakonwan and da Silva Figueiredo Celestino Gomes, Priscila and Fortin, Cloé and Seeberger, Peter H. and Rognan, Didier and Rademacher, Christoph and Imberty, Anne and Titz, Alexander

Targeting the Central Pocket of the Pseudomonas aeruginosa Lectin LecA

ChemBioChem (2022)

23,

10.1002/CBIC.202100563

Hany, Romain and Leyris, Jean-Philippe and Bret, Guillaume and Mallié, Sylvie and Sar, Chamroeun and Thouaye, Maxime and Hamze, Abdallah and Provot, Olivier and Sokoloff, Pierre and Valmier, Jean and Villa, Pascal and Rognan, Didier

High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators

ACS Chemical Biology (2022)

17, 709-722

10.1021/ACSCHEMBIO.2C00048

Volkov, Mikhail and Turk, Joseph-André and Drizard, Nicolas and Martin, Nicolas and Hoffmann, Brice and Gaston-Mathé, Yann and Rognan, Didier

On the Frustration to Predict Binding Affinities from Protein-Ligand Structures with Deep Neural Networks

Journal of Medicinal Chemistry (2022)

65, 7946-7958

10.1021/ACS.JMEDCHEM.2C00487

Eguida, Merveille and Rognan, Didier

Estimating the Similarity between Protein Pockets

International Journal of Molecular Sciences (2022)

23, 12462

10.3390/IJMS232012462

Eguida, Merveille and Schmitt-Valencia, Christel and Hibert, Marcel and Villa, Pascal and Rognan, Didier

Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking

Journal of Medicinal Chemistry (2022)

65, 13771-13783

10.1021/ACS.JMEDCHEM.2C00931

Perebyinis, Mariana and Rognan, Didier

Overlap of On-demand Ultra-large Combinatorial Spaces with On-the-shelf Drug-like Libraries

Molecular Informatics (2023)

42,

10.1002/MINF.202200163

Sindt, François and Seyller, Anthony and Eguida, Merveille and Rognan, Didier

Protein Structure-Based Organic Chemistry-Driven Ligand Design from Ultralarge Chemical Spaces

ACS Central Science (2024)

10, 615-627

10.1021/ACSCENTSCI.3C01521

Eguida, Merveille and Bret, Guillaume and Sindt, François and Li, Fengling and Chau, Irene and Ackloo, Suzanne and Arrowsmith, Cheryl and Bolotokova, Albina and Ghiabi, Pegah and Gibson, Elisa and Halabelian, Levon and Houliston, Scott and Harding, Rachel J. and Hutchinson, Ashley and Loppnau, Peter and Perveen, Sumera and Seitova, Almagul and Zeng, Hong and Schapira, Matthieu and Rognan, Didier

Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2

Journal of Chemical Information and Modeling (2024)

64, 5344-5355

10.1021/ACS.JCIM.4C00601

Li, Fengling and Ackloo, Suzanne and Arrowsmith, Cheryl H. and Ban, Fuqiang and Barden, Christopher J. and Beck, Hartmut and Beránek, Jan and Berenger, Francois and Bolotokova, Albina and Bret, Guillaume and Breznik, Marko and Carosati, Emanuele and Chau, Irene and Chen, Yu and Cherkasov, Artem and Corte, Dennis Della and Denzinger, Katrin and Dong, Aiping and Draga, Sorin and Dunn, Ian and Edfeldt, Kristina and Edwards, Aled and Eguida, Merveille and Eisenhuth, Paul and Friedrich, Lukas and Fuerll, Alexander and Gardiner, Spencer S and Gentile, Francesco and Ghiabi, Pegah and Gibson, Elisa and Glavatskikh, Marta and Gorgulla, Christoph and Guenther, Judith and Gunnarsson, Anders and Gusev, Filipp and Gutkin, Evgeny and Halabelian, Levon and Harding, Rachel J. and Hillisch, Alexander and Hoffer, Laurent and Hogner, Anders and Houliston, Scott and Irwin, John J and Isayev, Olexandr and Ivanova, Aleksandra and Jacquemard, Celien and Jarrett, Austin J and Jensen, Jan H. and Kireev, Dmitri and Kleber, Julian and Koby, S. Benjamin and Koes, David and Kumar, Ashutosh and Kurnikova, Maria G. and Kutlushina, Alina and Lessel, Uta and Liessmann, Fabian and Liu, Sijie and Lu, Wei and Meiler, Jens and Mettu, Akhila and Minibaeva, Guzel and Moretti, Rocco and Morris, Connor J and Narangoda, Chamali and Noonan, Theresa and Obendorf, Leon and Pach, Szymon and Pandit, Amit and Perveen, Sumera and Poda, Gennady and Polishchuk, Pavel and Puls, Kristina and Pütter, Vera and Rognan, Didier and Roskams-Edris, Dylan and Schindler, Christina and Sindt, François and Spiwok, Vojtech and Steinmann, Casper and Stevens, Rick L. and Talagayev, Valerij and Tingey, Damon and Vu, Oanh and Walters, W. Patrick and Wang, Xiaowen and Wang, Zhenyu and Wolber, Gerhard and Wolf, Clemens Alexander and Wortmann, Lars and Zeng, Hong and Zepeda, Carlos A. and Zhang, Kam Y. J. and Zhang, Jixian and Zheng, Shuangjia and Schapira, Matthieu

CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein

Journal of Chemical Information and Modeling (2024)

64, 8521-8536

10.1021/ACS.JCIM.4C01267

Kozyrev, Vladimir and Sindt, François and Rognan, Didier

Active Learning to Select the Most Suitable Reagents and One-Step Organic Chemistry Reactions for Prioritizing Target-Specific Hits from Ultralarge Chemical Spaces

Journal of Chemical Information and Modeling (2025)

65, 693-704

10.1021/ACS.JCIM.4C02097

Laskaris, Paris and Vicentefranqueira, Rocío and Helynck, Olivier and Jouvion, Grégory and Calera, José Antonio and du Merle, Laurence and Suzenet, Franck and Buron, Frédéric and de Sousa, Rodolphe Alves and Mansuy, Daniel and Cavaillon, Jean-Marc and Latgé, Jean-Paul and Munier-Lehmann, Hélène and Ibrahim-Granet, Oumaima

A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism

Antimicrobial Agents and Chemotherapy (2018)

62,

10.1128/AAC.02510-17

Hayek, Simon and Bekaddour, Nassima and Besson, Laurie and Alves de Sousa, Rodolphe and Pietrancosta, Nicolas and Viel, Sébastien and Smith, Nikaia and Jacob, Yves and Nisole, Sébastien and Mandal, Rupasri and Wishart, David S. and Walzer, Thierry and Herbeuval, Jean-Philippe and Vidalain, Pierre-Olivier

Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay

SLAS Discovery (2019)

24, 25-37

10.1177/2472555218797078

Shanina, Elena and Kuhaudomlarp, Sakonwan and Siebs, Eike and Fuchsberger, Felix F. and Denis, Maxime and da Silva Figueiredo Celestino Gomes, Priscila and Clausen, Mads H. and Seeberger, Peter H. and Rognan, Didier and Titz, Alexander and Imberty, Anne and Rademacher, Christoph

Targeting undruggable carbohydrate recognition sites through focused fragment library design

Communications Chemistry (2022)

5,

10.1038/S42004-022-00679-3

Hayek, Simon and Pietrancosta, Nicolas and Hovhannisyan, Anna A. and Alves de Sousa, Rodolphe and Bekaddour, Nassima and Ermellino, Laura and Tramontano, Enzo and Arnould, Stéphanie and Sardet, Claude and Dairou, Julien and Diaz, Olivier and Lotteau, Vincent and Nisole, Sébastien and Melikyan, Gagik and Herbeuval, Jean-Philippe and Vidalain, Pierre-Olivier

Cerpegin-derived furo[3,4-c]pyridine-3,4(1H,5H)-diones enhance cellular response to interferons by de novo pyrimidine biosynthesis inhibition

European Journal of Medicinal Chemistry (2020)

186, 111855

10.1016/J.EJMECH.2019.111855

Ashraf, Usama and Tengo, Laura and Le Corre, Laurent and Fournier, Guillaume and Busca, Patricia and McCarthy, Andrew A. and Rameix-Welti, Marie-Anne and Gravier-Pelletier, Christine and Ruigrok, Rob W. H. and Jacob, Yves and Vidalain, Pierre-Olivier and Pietrancosta, Nicolas and Crépin, Thibaut and Naffakh, Nadia

Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy

Proceedings of the National Academy of Sciences (2019)

116, 10968-10977

10.1073/PNAS.1901214116

Frei, Angelo and Zuegg, Johannes and Elliott, Alysha G. and Baker, Murray and Braese, Stefan and Brown, Christopher and Chen, Feng and G. Dowson, Christopher and Dujardin, Gilles and Jung, Nicole and King, A. Paden and Mansour, Ahmed M. and Massi, Massimiliano and Moat, John and Mohamed, Heba A. and Renfrew, Anna K. and Rutledge, Peter J. and Sadler, Peter J. and Todd, Matthew H. and Willans, Charlotte E. and Wilson, Justin J. and Cooper, Matthew A. and Blaskovich, Mark A. T.

Metal complexes as a promising source for new antibiotics

Chemical Science (2020)

11, 2627-2639

10.1039/C9SC06460E

Brikci-Nigassa, Nahida Mokhtari and Bentabed-Ababsa, Ghenia and Erb, William and Chevallier, Floris and Picot, Laurent and Vitek, Lucille and Fleury, Audrey and Thiéry, Valérie and Souab, Mohamed and Robert, Thomas and Ruchaud, Sandrine and Bach, Stéphane and Roisnel, Thierry and Mongin, Florence

2-Aminophenones, a common precursor to N-aryl isatins and acridines endowed with bioactivities

Tetrahedron (2018)

74, 1785-1801

10.1016/J.TET.2018.02.038

von Mässenhausen, Anne and Tonnus, Wulf and Himmerkus, Nina and Parmentier, Simon and Saleh, Danish and Rodriguez, Diego and Ousingsawat, Jiraporn and Ang, Rosalind L. and Weinberg, Joel M. and Sanz, Ana B. and Ortiz, Alberto and Zierleyn, Adrian and Becker, Jan Ulrich and Baratte, Blandine and Desban, Nathalie and Bach, Stéphane and Schiessl, Ina Maria and Nogusa, Shoko and Balachandran, Siddharth and Anders, Hans Joachim and Ting, Adrian T. and Bleich, Markus and Degterev, Alexei and Kunzelmann, Karl and Bornstein, Stefan R. and Green, Douglas R. and Hugo, Christian and Linkermann, Andreas

Phenytoin inhibits necroptosis

Cell Death & Disease (2018)

9,

10.1038/S41419-018-0394-3

Oyallon, Bruno and Brachet-Botineau, Marie and Logé, Cédric and Bonnet, Pascal and Souab, Mohamed and Robert, Thomas and Ruchaud, Sandrine and Bach, Stéphane and Berthelot, Pascal and Gouilleux, Fabrice and Viaud-Massuard, Marie-Claude and Denevault-Sabourin, Caroline

Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors

European Journal of Medicinal Chemistry (2018)

154, 101-109

10.1016/J.EJMECH.2018.04.056

Dao, Viet Hung and Ourliac-Garnier, Isabelle and Bazin, Marc-Antoine and Jacquot, Catherine and Baratte, Blandine and Ruchaud, Sandrine and Bach, Stéphane and Grovel, Olivier and Le Pape, Patrice and Marchand, Pascal

Benzofuro[3,2-d]pyrimidines inspired from cercosporamide CaPkc1 inhibitor: Synthesis and evaluation of fluconazole susceptibility restoration

Bioorganic & Medicinal Chemistry Letters (2018)

28, 2250-2255

10.1016/J.BMCL.2018.05.044

Winfield, Hannah J. and Cahill, Michael M. and O'Shea, Kevin D. and Pierce, Larry T. and Robert, Thomas and Ruchaud, Sandrine and Bach, Stéphane and Marchand, Pascal and McCarthy, Florence O.

Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition

Bioorganic & Medicinal Chemistry (2018)

26, 4209-4224

10.1016/J.BMC.2018.07.012

Serive, Benoît and Bach, Stéphane

Marine Pigment Diversity: Applications and Potential

Blue Biotechnology (2018)

, 643-681

10.1002/9783527801718.CH20

Lassagne, Frédéric and Langlais, Timothy and Caytan, Elsa and Limanton, Emmanuelle and Paquin, Ludovic and Boullard, Manon and Courtel, Coline and Curbet, Idriss and Gédéon, Clément and Lebreton, Julien and Picot, Laurent and Thiéry, Valérie and Souab, Mohamed and Baratte, Blandine and Ruchaud, Sandrine and Bach, Stéphane and Roisnel, Thierry and Mongin, Florence

From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines

Molecules (2018)

23, 2961

10.3390/MOLECULES23112961

Maslyk, Maciej and Janeczko, Monika and Martyna, Aleksandra and Czernik, Slawomir and Tokarska-Rodak, Malgorzata and Chwedczuk, Marta and Foll-Josselin, Béatrice and Ruchaud, Sandrine and Bach, Stéphane and Demchuk, Oleg M. and Kubinski, Konrad

The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases

Molecules (2019)

24, 153

10.3390/MOLECULES24010153

Tazarki, Helmi and Zeinyeh, Wael and Esvan, Yannick J. and Knapp, Stefan and Chatterjee, Deep and Schröder, Martin and Joerger, Andreas C. and Khiari, Jameleddine and Josselin, Béatrice and Baratte, Blandine and Bach, Stéphane and Ruchaud, Sandrine and Anizon, Fabrice and Giraud, Francis and Moreau, Pascale

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis

European Journal of Medicinal Chemistry (2019)

166, 304-317

10.1016/J.EJMECH.2019.01.052

Motuhi, Sofia-Eléna and Feizbakhsh, Omid and Foll-Josselin, Béatrice and Baratte, Blandine and Delehouzé, Claire and Cousseau, Arnaud and Fant, Xavier and Bulinski, Jeannette Chloë and Payri, Claude Elisabeth and Ruchaud, Sandrine and Mehiri, Mohamed and Bach, Stéphane

Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides

Marine Drugs (2019)

17, 93

10.3390/MD17020093

Oukoloff, Killian and Coquelle, Nicolas and Bartolini, Manuela and Naldi, Marina and Le Guevel, Rémy and Bach, Stéphane and Josselin, Béatrice and Ruchaud, Sandrine and Catto, Marco and Pisani, Leonardo and Denora, Nunzio and Iacobazzi, Rosa Maria and Silman, Israel and Sussman, Joel L. and Buron, Frédéric and Colletier, Jacques-Philippe and Jean, Ludovic and Routier, Sylvain and Renard, Pierre-Yves

Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3

European Journal of Medicinal Chemistry (2019)

168, 58-77

10.1016/J.EJMECH.2018.12.063

Zeinyeh, Wael and Esvan, Yannick J. and Josselin, Béatrice and Baratte, Blandine and Bach, Stéphane and Nauton, Lionel and Théry, Vincent and Ruchaud, Sandrine and Anizon, Fabrice and Giraud, Francis and Moreau, Pascale

Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies

Bioorganic & Medicinal Chemistry (2019)

27, 2083-2089

10.1016/J.BMC.2019.04.005

Khaldoun, Khadidja and Safer, Abdelmounaim and Boukabcha, Nourdine and Dege, Necmi and Ruchaud, Sandrine and Souab, Mohamed and Bach, Stéphane and Chouaih, Abdelkader and Saidi-Besbes, Salima

Synthesis and evaluation of new isatin-aminorhodanine hybrids as PIM1 and CLK1 kinase inhibitors

Journal of Molecular Structure (2019)

1192, 82-90

10.1016/J.MOLSTRUC.2019.04.122

Ziane, S. and Mazari, M. M. and Safer, A. M. and Sad El Hachemi Amar, A. and Ruchaud, S. and Baratte, B. and Bach, S.

Comparison between Conventional and Nonconventional Methods for the Synthesis of Some 2-Oxazolidinone Derivatives and Preliminary Investigation of Their Inhibitory Activity Against Certain Protein Kinases

Russian Journal of Organic Chemistry (2019)

55, 1061-1069

10.1134/S1070428019070248

Nguyen, Thi-Ngoc-Dung and Feizbakhsh, Omid and Sfecci, Estelle and Baratte, Blandine and Delehouzé, Claire and Garcia, Adrien and Moulin, Corentin and Colas, Pierre and Ruchaud, Sandrine and Mehiri, Mohamed and Bach, Stéphane

Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge Crambe tailliezi

Marine Drugs (2019)

17, 569

10.3390/MD17100569

Mokhtari Brikci-Nigassa, Nahida and Nauton, Lionel and Moreau, Pascale and Mongin, Olivier and Duval, Raphaël E. and Picot, Laurent and Thiéry, Valérie and Souab, Mohamed and Baratte, Blandine and Ruchaud, Sandrine and Bach, Stéphane and Le Guevel, Rémy and Bentabed-Ababsa, Ghenia and Erb, William and Roisnel, Thierry and Dorcet, Vincent and Mongin, Florence

Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest

Bioorganic Chemistry (2020)

94, 103347

10.1016/J.BIOORG.2019.103347

Nascimento da Cruz, Anne Cecília and Brondani, Dalci José and I'talo de Santana, Temístocles and Oliveira da Silva, Lucas and da Oliveira Borba, Elizabeth Fernanda and de Faria, Antônio Rodolfo and Ferreira Cavalcanti de Albuquerque, Julianna and Piessard, Sylvie and Matos Ximenes, Rafael and Baratte, Blandine and Bach, Stéphane and Ruchaud, Sandrine and Bezerra Mendonça Junior, Francisco Jaime and Bazin, Marc-Antoine and Montenegro Rabello, Marcelo and Hernandes, Marcelo Zaldini and Marchand, Pascal and Gonçalves da Silva, Teresinha

Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents

Pharmaceuticals (2019)

12, 169

10.3390/PH12040169

Lassagne, Frédéric and Duguépéroux, Camille and Roca, Carlos and Perez, Concepcion and Martinez, Ana and Baratte, Blandine and Robert, Thomas and Ruchaud, Sandrine and Bach, Stéphane and Erb, William and Roisnel, Thierry and Mongin, Florence

From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3)

Organic & Biomolecular Chemistry (2020)

18, 154-162

10.1039/C9OB02002K

Robert, Thomas and Johnson, Jared L. and Guichaoua, Roxane and Yaron, Tomer M. and Bach, Stéphane and Cantley, Lewis C. and Colas, Pierre

Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors

Frontiers in Chemistry (2020)

8,

10.3389/FCHEM.2020.00147

Qhobosheane, Malikotsi A. and Legoabe, Lesetja J. and Josselin, Béatrice and Bach, Stéphane and Ruchaud, Sandrine and Petzer, Jacobus P. and Beteck, Richard M.

Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors

Bioorganic & Medicinal Chemistry (2020)

28, 115468

10.1016/J.BMC.2020.115468

Benchekroun, Mohamed and Ermolenko, Ludmila and Tran, Minh Quan and Vagneux, Agathe and Nedev, Hristo and Delehouzé, Claire and Souab, Mohamed and Baratte, Blandine and Josselin, Béatrice and Iorga, Bogdan I. and Ruchaud, Sandrine and Bach, Stéphane and Al-Mourabit, Ali

Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1

European Journal of Medicinal Chemistry (2020)

201, 112337

10.1016/J.EJMECH.2020.112337

Ibrahim, Nada and Bonnet, Pascal and Brion, Jean-Daniel and Peyrat, Jean-François and Bignon, Jerome and Levaique, Helene and Josselin, Béatrice and Robert, Thomas and Colas, Pierre and Bach, Stéphane and Messaoudi, Samir and Alami, Mouad and Hamze, Abdallah

Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency

European Journal of Medicinal Chemistry (2020)

199, 112355

10.1016/J.EJMECH.2020.112355

Bach, Stéphane and Colas, Pierre and Blondel, Marc

La levure modèle et outil... aussi pour la recherche thérapeutique

médecine/sciences (2020)

36, 504-514

10.1051/MEDSCI/2020077

Bouattour, Ali and Fakhfakh, Mehdi and Abid, Souhir and Paquin, Ludovic and Guével, Rémy Le and Charlier, Thierry and Ruchaud, Sandrine and Bach, Stéphane and Bazureau, Jean-Pierre and Ammar, Houcine

Synthesis of New 2-Phenylamino-4<i>H</i>-chromene-3-carbonitrile Derivatives and Their Effects on Tumor Cell Lines and against Protein Kinases

International Journal of Organic Chemistry (2020)

10, 88-103

10.4236/IJOC.2020.102006

Pieterse, Lianie and Legoabe, Lesetja J. and Beteck, Richard M. and Josselin, Béatrice and Bach, Stéphane and Ruchaud, Sandrine

Synthesis and biological evaluation of selected 7-azaindole derivatives as CDK9/Cyclin T and Haspin inhibitors

Medicinal Chemistry Research (2020)

29, 1449-1462

10.1007/S00044-020-02560-1

Cousseau, Arnaud and Siano, Raffaele and Probert, Ian and Bach, Stéphane and Mehiri, Mohamed

Marine dinoflagellates as a source of new bioactive structures

Studies in Natural Products Chemistry (2020)

, 125-171

10.1016/B978-0-12-817905-5.00004-4

Esvan, Yannick J. and Josselin, Béatrice and Baratte, Blandine and Bach, Stéphane and Ruchaud, Sandrine and Anizon, Fabrice and Giraud, Francis and Moreau, Pascale

Synthesis and kinase inhibitory potencies of new pyrido[3,4-g]quinazolines substituted at the 8-position

Arkivoc (2020)

2020, 105-116

10.24820/ARK.5550190.P011.268

Tuescher, Jan M. and Tailfeathers, Deserae and Kernéis, Sophie M. and Baratte, Blandine and Ruchaud, Sandrine and Bach, Stéphane and Batut, Muriel and Pouny, Isabelle and Sautel, François and Golsteyn, Roy M.

The Canadian Prairie Plant Thermopsis rhombifolia Contains Luteolin, a Flavone that Inhibits Cyclin Dependent Kinase 9 and Arrest Cells in the G1-Phase of the Cell Cycle

Journal of Natural Health Product Research (2020)

2, 1-14

10.33211/JNHPR.12

Wilde, Myron and Arzur, Danielle and Baratte, Blandine and Lefebvre, Dorian and Robert, Thomas and Roisnel, Thierry and Le Jossic-Corcos, Catherine and Bach, Stéphane and Corcos, Laurent and Erb, William

Regorafenib analogues and their ferrocenic counterparts: synthesis and biological evaluation

New Journal of Chemistry (2020)

44, 19723-19733

10.1039/D0NJ05334A

Elie, Jonathan and Feizbakhsh, Omid and Desban, Nathalie and Josselin, Béatrice and Baratte, Blandine and Bescond, Amandine and Duez, Julien and Fant, Xavier and Bach, Stéphane and Marie, Dominique and Place, Matthieu and Ben Salah, Sami and Chartier, Agnes and Berteina-Raboin, Sabine and Chaikuad, Apirat and Knapp, Stefan and Carles, Fabrice and Bonnet, Pascal and Buron, Frédéric and Routier, Sylvain and Ruchaud, Sandrine

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry (2020)

35, 1840-1853

10.1080/14756366.2020.1825408

Bazin, Marc-Antoine and Cojean, Sandrine and Pagniez, Fabrice and Bernadat, Guillaume and Cavé, Christian and Ourliac-Garnier, Isabelle and Nourrisson, Marie-Renée and Morgado, Cathy and Picot, Carine and Leclercq, Olivier and Baratte, Blandine and Robert, Thomas and Späth, Gérald F. and Rachidi, Najma and Bach, Stéphane and Loiseau, Philippe M. and Le Pape, Patrice and Marchand, Pascal

In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition

European Journal of Medicinal Chemistry (2021)

210, 112956

10.1016/J.EJMECH.2020.112956

Garcia-Princival, Iza Mirela Rodini and Princival, Jefferson Luiz and Dias da Silva, Emmanuel and de Arruda Lima, Sandrine Maria and Carregosa, Jhonattas Carvalho and Wisniewski Jr, Alberto and de Lucena, Caio Cézar Oliveira and Halwass, Fernando and Alves Franca, José Adonias and Ferreira, Luiz Felipe Gomes Rebello and Hernandes, Marcelo Zaldini and Saraiva, Karina Lidianne Alcântara and Peixoto, Christina Alves and Baratte, Blandine and Robert, Thomas and Bach, Stéphane and Gomes, Dayene Correia and Guedes Paiva, Patricia Maria and Marchand, Pascal and Rodrigues, Maria do Desterro and Gonçalves da Silva, Teresinha

Streptomyces hygroscopicus UFPEDA 3370: A valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells

Chemico-Biological Interactions (2021)

333, 109316

10.1016/J.CBI.2020.109316

Brahmaiah, Dabbugoddu and Kanaka Durga Bhavani, Anagani and Aparna, Pasula and Sampath Kumar, Nangunoori and Solhi, Hélène and Le Guevel, Rémy and Baratte, Blandine and Ruchaud, Sandrine and Bach, Stéphane and Singh Jadav, Surender and Raji Reddy, Chada and Roisnel, Thierry and Mosset, Paul and Levoin, Nicolas and Grée, René

Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase

Bioorganic & Medicinal Chemistry (2021)

31, 115962

10.1016/J.BMC.2020.115962

Pieterse, Lianie and Beteck, Richard M. and Baratte, Blandine and Jesumoroti, Omobolanle J. and Robert, Thomas and Ruchaud, Sandrine and Bach, Stéphane and Legoabe, Lesetja J.

Synthesis and biological evaluation of selected 7H-pyrrolo[2,3-d]pyrimidine derivatives as novel CDK9/CyclinT and Haspin inhibitors

Chemico-Biological Interactions (2021)

349, 109643

10.1016/J.CBI.2021.109643

Choudhary, Bhanwar Singh and Sukanya and Mehta, Pakhuri and Bach, Stephane and Ruchaud, Sandrine and Robert, Thomas and Josselin, Beatrice and Filipek, Slawomir and Malik, Ruchi

Discovery of thiazolidin-4-one analogue as selective GSK-3ß inhibitor through structure based virtual screening

Bioorganic & Medicinal Chemistry Letters (2021)

52, 128375

10.1016/J.BMCL.2021.128375

Dao, Viet Hung and Ourliac-Garnier, Isabelle and Logé, Cédric and McCarthy, Florence O. and Bach, Stéphane and da Silva, Teresinha Gonçalves and Denevault-Sabourin, Caroline and Thiéfaine, Jérôme and Baratte, Blandine and Robert, Thomas and Gouilleux, Fabrice and Brachet-Botineau, Marie and Bazin, Marc-Antoine and Marchand, Pascal

Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases

Molecules (2021)

26, 6572

10.3390/MOLECULES26216572

Zeinyeh, Wael and Esvan, Yannick J. and Josselin, Béatrice and Defois, Mathilde and Baratte, Blandine and Knapp, Stefan and Chaikuad, Apirat and Anizon, Fabrice and Giraud, Francis and Ruchaud, Sandrine and Moreau, Pascale

Synthesis and biological evaluation of Haspin inhibitors: Kinase inhibitory potency and cellular activity

European Journal of Medicinal Chemistry (2022)

236, 114369

10.1016/J.EJMECH.2022.114369

Almeida, Jackson and Grougnet, Raphaël and Quintans, Lucindo and Chevalier, Sylvie and Feuilloley, Marc and Robert, Thomas and Bach, Stéphane and Oliveira, Raimundo and Thiéry, Valérie and Bazureau, Jean-Pierre and Mongin, Florence and Kritsanida, Marina and Sol, Vincent and Costa, Vicente and Bourgougnon, Nathalie and Marchand, Pascal and Picot, Laurent

THE FRANCO-BRAZILIAN NETWORK ON NATURAL PRODUCTS (FB2NP): A NEW NETWORK PROMOTING COOPERATION AND EXCHANGES IN NATURAL PRODUCTS RESEARCH

Química Nova (2021)

,

10.21577/0100-4042.20170847

Avula, Sreenivas and Peng, Xudan and Lang, Xingfen and Tortorella, Micky and Josselin, Béatrice and Bach, Stéphane and Bourg, Stephane and Bonnet, Pascal and Buron, Frédéric and Ruchaud, Sandrine and Routier, Sylvain and Neagoie, Cleopatra

Design and biological evaluation of substituted 5,7-dihydro-6 H -indolo[2,3- c ]quinolin-6-one as novel selective Haspin inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry (2022)

37, 1632-1650

10.1080/14756366.2022.2082419

Brahmaiah, Dabbugoddu and Bhavani, Anagani Kanaka Durga and Aparna, Pasula and Kumar, Nangunoori Sampath and Solhi, Hélène and Le Guevel, Rémy and Baratte, Blandine and Robert, Thomas and Ruchaud, Sandrine and Bach, Stéphane and Jadav, Surender Singh and Reddy, Chada Raji and Mosset, Paul and Gouault, Nicolas and Levoin, Nicolas and Grée, René

Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases

Molecules (2022)

27, 6149

10.3390/MOLECULES27196149

Juillet, Charlotte and Ermolenko, Ludmila and Boyarskaya, Dina and Baratte, Blandine and Josselin, Béatrice and Nedev, Hristo and Bach, Stéphane and Iorga, Bogdan I. and Bignon, Jérôme and Ruchaud, Sandrine and Al-Mourabit, Ali

From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase

Journal of Medicinal Chemistry (2021)

64, 1197-1219

10.1021/ACS.JMEDCHEM.0C02064

Oyallon, Bruno and Brachet-Botineau, Marie and Logé, Cédric and Robert, Thomas and Bach, Stéphane and Ibrahim, Sajida and Raoul, William and Croix, Cécile and Berthelot, Pascal and Guillon, Jean and Pinaud, Noël and Gouilleux, Fabrice and Viaud-Massuard, Marie-Claude and Denevault-Sabourin, Caroline

New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation

Molecules (2021)

26, 867

10.3390/MOLECULES26040867

Lassagne, Frédéric and Sims, Joshua M. and Erb, William and Mongin, Olivier and Richy, Nicolas and El Osmani, Nour and Fajloun, Ziad and Picot, Laurent and Thiéry, Valérie and Robert, Thomas and Bach, Stéphane and Dorcet, Vincent and Roisnel, Thierry and Mongin, Florence

Thiazolo[5,4-f]quinoxalines, Oxazolo[5,4-f]quinoxalines and Pyrazino[b,e]isatins: Synthesis from 6-Aminoquinoxalines and Properties

European Journal of Organic Chemistry (2021)

2021, 2756-2763

10.1002/EJOC.202100362

Qhobosheane, Malikotsi A. and Beteck, Richard M. and Baratte, Blandine and Robert, Thomas and Ruchaud, Sandrine and Bach, Stéphane and Legoabe, Lesetja J.

Exploration of 7-azaindole-coumaranone hybrids and their analogues as protein kinase inhibitors

Chemico-Biological Interactions (2021)

343, 109478

10.1016/J.CBI.2021.109478

Ahmadu, Augustine A. and Delehouzé, Claire and Haruna, Anas and Mustapha, Lukman and Lawal, Bilqis A. and Udobre, Aniefiok and Baratte, Blandine and Triscornia, Camilla and Autret, Axelle and Robert, Thomas and Bulinski, Jeannette Chloë and Rousselot, Morgane and Simoes Eugénio, Mélanie and Dimanche-Boitrel, Marie-Thérèse and Petzer, Jacobus P. and Legoabe, Lesetja J. and Bach, Stéphane

Betulin, a Newly Characterized Compound in Acacia auriculiformis Bark, Is a Multi-Target Protein Kinase Inhibitor

Molecules (2021)

26, 4599

10.3390/MOLECULES26154599

Dhiabi, Marwa and Bouattour, Ali and Fakhfakh, Mehdi and Abid, Souhir and Paquin, Ludovic and Robert, Thomas and Bach, Stephane and Bazureau, Jean-Pierre and Ammar, Houcine

Practical approach to N-benzyl derivatives of 2-amino-8-methoxy-4H-chromene-3-carbonitrile by reductive amination: Exploration of their effects against protein kinases and in silico ADME profiling

Journal of Molecular Structure (2023)

1274, 134319

10.1016/J.MOLSTRUC.2022.134319

Mast, Nicolas and Erb, William and Nauton, Lionel and Moreau, Pascale and Mongin, Olivier and Roisnel, Thierry and Macaigne, Margaux and Robert, Thomas and Bach, Stéphane and Picot, Laurent and Thiéry, Valérie and Hurvois, Jean-Pierre and Mongin, Florence

From benzofuro-, benzothieno- and 10-methylindolo-[2,3-b]-fused benzothiopyrano[4,3,2-de]quinolines to the corresponding benzothiopyrano[4,3,2-de]1,8-naphthyridines: synthesis and properties of these hexacyclic heteroaromatic compounds

New Journal of Chemistry (2023)

47, 258-283

10.1039/D2NJ04567B

Hasanvand, Zaman and Oghabi Bakhshaiesh, Tayebeh and Peytam, Fariba and Firoozpour, Loghman and Hosseinzadeh, Elaheh and Motahari, Rasoul and Moghimi, Setareh and Nazeri, Elaheh and Toolabi, Mahsa and Momeni, Farhad and Bijanzadeh, Hamidreza and Khalaj, Ali and Baratte, Blandine and Josselin, Béatrice and Robert, Thomas and Bach, Stéphane and Esmaeili, Rezvan and Foroumadi, Alireza

Imidazo[1,2-a]quinazolines as novel, potent EGFR-TK inhibitors: Design, synthesis, bioactivity evaluation, and in silico studies

Bioorganic Chemistry (2023)

133, 106383

10.1016/J.BIOORG.2023.106383

Hasyeoui, Mohamed and Lassagne, Frédéric and Erb, William and Nael, Manal and Elokely, Khaled M. and Chaikuad, Apirat and Knapp, Stefan and Jorda, Adrian and Vallés, Soraya L. and Quissac, Emie and Verreault, Maïté and Robert, Thomas and Bach, Stéphane and Samarat, Ali and Mongin, Florence

Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3alpha (GSK-3alpha): Development and impact on temozolomide treatment of glioblastoma cells

Bioorganic Chemistry (2023)

134, 106456

10.1016/J.BIOORG.2023.106456

Ribeiro E. Silva, Adeline and Diallo, Mamadou Amadou and Sausset, Alix and Robert, Thomas and Bach, Stéphane and Bussière, Françoise I. and Laurent, Fabrice and Lacroix-Lamandé, Sonia and Silvestre, Anne

Overexpression of Eimeria tenella Rhoptry Kinase 2 Induces Early Production of Schizonts

Microbiology Spectrum (2023)

11,

10.1128/SPECTRUM.00137-23

Moradi, Mahfam and Mousavi, Alireza and Emamgholipour, Zahra and Giovannini, Johanna and Moghimi, Setareh and Peytam, Fariba and Honarmand, Amin and Bach, Stéphane and Foroumadi, Alireza

Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies

European Journal of Medicinal Chemistry (2023)

259, 115626

10.1016/J.EJMECH.2023.115626

Kieffer, C. and Primas, N. and Hutter, S. and Merckx, A. and Reininger, L. and Bach, S. and Ruchaud, S. and Gaillard, F. and Laget, M. and Amrane, D. and Hervé, L. and Castera-Ducros, C. and Renault, J. and Dumètre, A. and Rault, S. and Doerig, C. and Rathelot, P. and Vanelle, P. and Azas, N. and Verhaeghe, P.

Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound

Bioorganic & Medicinal Chemistry (2024)

102, 117654

10.1016/J.BMC.2024.117654

Laure, Arthur and Royet, Chloé and Bihel, Frederic and Baratte, Blandine and Bach, Stéphane and Peyressatre, Marion and Morris, May C.

Ethaverine and Papaverine Target Cyclin-Dependent Kinase 5 and Inhibit Lung Cancer Cell Proliferation and Migration

ACS Pharmacology & Translational Science (2024)

7, 1377-1385

10.1021/ACSPTSCI.4C00023

Bakalakou, Vaia-Argyro and Mavroidi, Barbara and Kalampaliki, Amalia D. and Josselin, Béatrice and Bach, Stéphane and Skaltsounis, Alexios-Leandros and Marakos, Panagiotis and Pouli, Nicole and Pelecanou, Maria and Myrianthopoulos, Vassilios and Ruchaud, Sandrine and Kostakis, Ioannis K.

The pyrazolo[4,3-c]pyrazole core as a novel and versatile scaffold for developing dual DYRK1A-CLK1 inhibitors targeting key processes of Alzheimer's disease pathology

European Journal of Medicinal Chemistry Reports (2024)

12, 100193

10.1016/J.EJMCR.2024.100193

Pham, Giang Nam and Josselin, Béatrice and Cousseau, Arnaud and Baratte, Blandine and Dayras, Marie and Le Meur, Christophe and Debaets, Stella and Weill, Amélie and Robert, Thomas and Burgaud, Gaëtan and Probert, Ian and Abdoul-Latif, Fatouma Mohamed and Boyer, Laurent and Bach, Stéphane and Mehiri, Mohamed

New Fusarochromanone Derivatives from the Marine Fungus Fusarium equiseti UBOCC-A-117302

Marine Drugs (2024)

22, 444

10.3390/MD22100444

Broudic, Nathan and Pacheco-Benichou, Alexandra and Corbière, Cécile and Baratte, Blandine and Robert, Thomas and Bach, Stéphane and Solhi, Hélène and Le Guével, Rémy and Fruit, Corinne and Besson, Thierry

Novel Thiazole-Fused [4,5-g] or [5,4-g]Quinazolin-8-ones and Their Quinazoline Analogues: Synthesis and Biological Evaluation

Pharmaceuticals (2024)

17, 1452

10.3390/PH17111452

Diakité, Amelanh Sica and Ambeu-Loko, Christelle N'ta Mélissa and Yapi, Ange Désiré and Logé, Cédric and Kacou, Alain and Kra, Stéphanie and Baratte, Blandine and Bach, Stéphane and Ruchaud, Sandrine and Sissouma, Drissa and Ouattara, Mahama and Robert, Jean-michel

Design and Synthesis of Functionalized 2,4-Diamino-1,3,5-Triazines, Potential Inhibitors Involved in Immune and Inflammatory Response

International Journal of Pharmaceutical Research and Allied Sciences (2024)

13, 1-11

10.51847/HST2C61XWX

Tisseur, Lhana and Cojean, Sandrine and Gassama, Khadidiatou and Logé, Cédric and Pagniez, Fabrice and Cavé, Christian and Bernadat, Guillaume and Loiseau, Philippe M. and Bach, Stéphane and Thiéfaine, Jérôme and Picot, Carine and Tomasoni, Christophe and Leclercq, Olivier and Baratte, Blandine and Robert, Thomas and Le Pape, Patrice and Rachidi, Najma and Bazin, Marc-Antoine and Marchand, Pascal

Investigating the C2 Modulation of the Imidazo[1,2-a]pyrazine-Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition

ChemMedChem (2025)

20,

10.1002/CMDC.202400862

Janeczko, Monika and Maslyk, Maciej and Demchuk, Oleg M. and Kurowska-Okon, Antonina and Kwasnik, Mateusz and Górka, Kamila and Martyna, Aleksandra and Foll-Josselin, Béatrice and Ruchaud, Sandrine and Bach, Stéphane and Wolinski, Przemyslaw and Jasinski, Radomir and Miroslaw, Barbara and Sadczuk, Malgorzata and Kubinski, Konrad

Development of a novel family of antifungal agents based on a quinone methide oxime framework

Scientific Reports (2025)

15,

10.1038/S41598-025-98609-5

Breaud, Célia and Lallemand, Laura and Mares, Gary and Mabrouki, Fathi and Bertolotti, Myriam and Simmler, Charlotte and Greff, Stéphane and Mauduit, Morgane and Herbette, Gaëtan and Garayev, Eldar and Lavergne, Christophe and Cesari, Maya and Bun-Llopet, Sok-Siya and Baghdikian, Béatrice and Garayev, Elnur

LC-MS Based Phytochemical Profiling towards the Identification of Antioxidant Markers in Some Endemic Aloe Species from Mascarene Islands

Antioxidants (2022)

12, 50

10.3390/ANTIOX12010050

Ceramella, Jessica and Rosano, Camillo and Iacopetta, Domenico and Ben Toumia, Iméne and Chekir-Ghedira, Leila and Maatouk, Mouna and Mariconda, Annaluisa and Longo, Pasquale and Dallemagne, Patrick and Rochais, Christophe and Sinicropi, Maria Stefania

Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative

Pharmaceutics (2025)

17, 415

10.3390/PHARMACEUTICS17040415

Al Assi, Alaa and Posty, Solène and Lamarche, Frédéric and Chebel, Amel and Guitton, Jérôme and Cottet-Rousselle, Cécile and Prudent, Renaud and Lafanechère, Laurence and Giraud, Stéphane and Dallemagne, Patrick and Suzanne, Peggy and Verney, Aurélie and Genestier, Laurent and Castets, Marie and Fontaine, Eric and Billaud, Marc and Cordier-Bussat, Martine

A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity

Cell Death & Disease (2024)

15,

10.1038/S41419-024-06668-9

Thieulent, Côme and Fortier, Christine and Munier-Lehmann, Hélène and Suzanne, Peggy and Dallemagne, Patrick and Zientara, Stephan and Hans, Aymeric and Paillot, Romain and Vidalain, Pierre-Olivier and Pronost, Stéphane and Hue, Erika

Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: Dataset of 2,891 compounds.

Data in Brief (2020)

33, 106492

10.1016/J.DIB.2020.106492

Thieulent, Côme and Hue, Erika S. and Sutton, Gabrielle and Fortier, Christine and Dallemagne, Patrick and Zientara, Stephan and Munier-Lehmann, Hélène and Hans, Aymeric and Paillot, Romain and Vidalain, Pierre-Olivier and Pronost, Stéphane

Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination

Antiviral Research (2020)

183, 104931

10.1016/J.ANTIVIRAL.2020.104931

Valle-Casuso, José-Carlos and Gaudaire, Delphine and Martin-Faivre, Lydie and Madeline, Anthony and Dallemagne, Patrick and Pronost, Stéphane and Munier-Lehmann, Hélène and Zientara, Stephan and Vidalain, Pierre-Olivier and Hans, Aymeric

Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors

Scientific Reports (2020)

10,

10.1038/S41598-020-66944-4

Thieulent, Côme J. and Hue, Erika S. and Fortier, Christine I. and Dallemagne, Patrick and Zientara, Stéphan and Munier-Lehmann, Hélène and Hans, Aymeric and Fortier, Guillaume D. and Pitel, Pierre-Hugues and Vidalain, Pierre-Olivier and Pronost, Stéphane L.

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay

Virology (2019)

526, 105-116

10.1016/J.VIROL.2018.10.013

Zhou, Zhicheng and Staropoli, Isabelle and Brelot, Anne and Suzanne, Peggy and Lesnard, Aurélien and Fontaine, Fanny and Perato, Serge and Rault, Sylvain and Helynck, Olivier and Arenzana-Seisdedos, Fernando and Sopkova-de Oliveira Santos, Jana and Lagane, Bernard and Munier-Lehmann, Hélène and Colin, Philippe

Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands

Molecules (2023)

28, 1156

10.3390/MOLECULES28031156

Bosson-Vanga, Henriette and Primas, Nicolas and Franetich, Jean-François and Lavazec, Catherine and Gomez, Lina and Ashraf, Kutub and Tefit, Maurel and Soulard, Valérie and Dereuddre-Bosquet, Nathalie and Le Grand, Roger and Donnette, Mélanie and Mustière, Romain and Amanzougaghene, Nadia and Tajeri, Shahin and Suzanne, Peggy and Malzert-Fréon, Aurélie and Rault, Sylvain and Vanelle, Patrice and Hutter, Sébastien and Cohen, Anita and Snounou, Georges and Roques, Pierre and Azas, Nadine and Lagardère, Prisca and Lisowski, Vincent and Masurier, Nicolas and Nguyen, Michel and Paloque, Lucie and Benoit-Vical, Françoise and Verhaeghe, Pierre and Mazier, Dominique

A New Thienopyrimidinone Chemotype Shows Multistage Activity against Plasmodium falciparum, Including Artemisinin-Resistant Parasites

Microbiology Spectrum (2021)

9,

10.1128/SPECTRUM.00274-21