Target nature :
NMD
CAS n° :
79238-06-5
Mecanism of action :
Inhibition of Nonsense-mediated mRNA decay
Physico-chemical properties :
Molecular weight: 281.74 g.mol-1 20 mg/mL in DMSO
Probe availability :
Chimiothèque Institut Curie-CNRS
Princeps reference :
Journal of Cell Biology 2007, 178, 1145. doi/10.1083/jcb.200611086 WO 2008101935
More bibliography :
PLoS ONE 2013 8(4): e60478. doi:10.1371/journal.pone.0060478 Cell Biosci (2017) 7:26 doi 10.1186/s13578-017-0153-7 Org Biomol Chem 2016, 14, 1559. DOI: 10.1039/c5ob02482j Tetrahedron (1981), 37(11), 2097 doi.org/10.1016/S0040-4020(01)97964-5
Other available information on the probe :
NA
Other information on the target :
NA
Selectivity profile :
NA
In vivo data :
NMDI-1 enhances PTC suppression in Idua W392X mice (Ref: PLoS ONE 2013 8(4): e60478. doi:10.1371/journal.pone.0060478) Co- administration with Gentamicin or NB84 at 5 mg/kg/d for 3 days subcutaneous injection (diluted in 1:3 cremophor-EL)
In vitro data :
NMDI-1 attenuates NMD by blocking hUPF1 phosphorylation.
Toxicity :
NA
Chaine SMILES :
Cc3c1ccnc(Cl)c1c(C)c4c2cccnc2[nH]c34
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