Opportunity for Affinity Selection Mass Spectrometry (ASMS) screen

My colleagues at the SGC set-up an Affinity Selection Mass Spectrometry (ASMS) platform where they will screen a set of ~10,000 diverse compounds against hundreds of proteins each year, as part of the target2035 initiative.  ASMS hits are then confirmed by SPR.

We see so far valid hits with 1µM < KD < 40 µM for  6 out of the first 28 targets, with follow-up co-xtal structures for 2 targets. These are not high-druggability targets (no kinase etc...) but E3 ligases, acetyltransferase, WDR domains, protein-protein binding domains,...

The rate limiting step is actually preparing high-quality protein samples, and we are accepting samples from anyone, as long as they are high-quality (pure, well behaved).

If you are  interested in sending us a batch of purified protein, we can try to generate hits for them. This is open science (no patent) but people are free to follow-up internally once hits are made public.

University of Toronto

matthieu.schapira@utoronto.ca